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A comprehensive study of the molecular active landscape of human cells can be undertaken to integrate two different but complementary perspectives: transcriptomics, and proteomics. After the genome era, proteomics has emerged as a powerful tool to simultaneously identify and characterize the compendium of thousands of different proteins active in a cell. Thus, the Chromosome-centric Human Proteome
AIMS: To explore the perceptions of informal caregivers and healthcare professionals regarding potential reasons for the institutionalization of older persons with dementia in eight European countries. BACKGROUND: Healthcare professionals may have an important role in facilitating informal caregivers' decision-making regarding institutionalization. Little is known about the perceptions of informal
Common diseases such as type 2 diabetes are phenotypically heterogeneous. Obesity is a major risk factor for type 2 diabetes, but patients vary appreciably in body mass index. We hypothesized that the genetic predisposition to the disease may be different in lean (BMI<25 Kg/m(2)) compared to obese cases (BMI >= 30 Kg/m(2)). We performed two case-control genome-wide studies using two accepted cut-o
A search for heavy leptons decaying to a Z boson and an electron or a muon is presented. The search is based on pp collision data taken at root s = 8TeV by the ATLAS experiment at the CERN Large Hadron Collider, corresponding to an integrated luminosity of 20.3 fb(-1). Three high-transverse-momentum electrons or muons are selected, with two of them required to be consistent with originating from a
Preclinical efficacy of continuous delivery of 3,4-dihydroxyphenylalanine (DOPA) with adeno-associated viral (AAV) vectors has recently been documented in animal models of Parkinson's disease (PD). So far, all studies have utilized a mix of two monocistronic vectors expressing either of the two genes, tyrosine hydroxylase (TH) and GTP cyclohydrolase-1 (GCH1), needed for DOPA production. Here, we p
The results of a search for supersymmetry in events with large missing transverse momentum and heavy-flavor jets using an integrated luminosity corresponding to 2.05 fb(-1) of pp collisions at root s = 7 TeV recorded with the ATLAS detector at the Large Hadron Collider are reported. No significant excess is observed with respect to the prediction for standard model processes. Results are interpret
The aim of this study was to investigate myocardial wall motion using echocardiography and color-coded tissue velocity imaging and to generate a cardiac state diagram for evaluation of the duration of the pre- and post-ejection phases in asphyxiated fetal lambs. Six near-term lambs were partly exteriorized and brought to cardiac arrest through asphyxia. Echocardiography measurements were recorded
Anaerobic digestion would enable the energy potential of agricultural crop residues such as ley crops and sugar beet tops to be harnessed in Sweden. In the present study, the financial prospects of single-stage fed-batch high-solids digestion on three different scales, 51, 67, and 201 kW, were calculated on the basis of experimental results and observations. In addition to scale, the effects of me
The aryl hydrocarbon receptor (AhR) mediates the toxicity of several environmental contaminants, e.g. 2,3,7,8-tetrachlorodibenzo-p-dioxin, and other halogenated hydrocarbons in vertebrates. This receptor initiates the transcription of several biotransformation enzymes, which in turn are responsible for causing severe harm to biological tissue. Here we describe the isolation and complete characteri
The responses to step and pulse transients with reactants have been simulated for conventional step-transient conditions at atmospheric pressure and pulsing under vacuum using a temporal analysis of products (TAP) reactor, respectively. Propene oxidation over an oxide catalyst with the participation of lattice oxygen was chosen as a model reaction. The mechanism comprises adsorption of the reactan
Over the last 25 years a number of new anaesthetic drugs have been introduced on the market to allow for better patient satisfaction and faster recovery after anaesthesia and sedation. Propofol (2,6-di-isopropylphenol), one of our most common iv anaesthetics, is associated with pleasant sleep and rapid recovery with little postoperative nausea. When used for anaesthetic induction propofol causes s
Using two epochs of HST/WFPC2 images of the metal-rich globular clusterNGC 6528 we derive the proper motions of the stars and use them toseparate the stars belonging to NGC 6528 from those of the Galacticbulge. The stellar sequences in the resulting colour-magnitude diagramfor the cluster are significantly better determined than in previouslypublished data. From comparison of the colour-magnitude
The goal of this research is to use hematopoietic cells as vehicles for targeting transgenic immunomodulators to the inflammatory sites. The work presented was focused on the anti-inflammatory soluble TNF receptor. A transmembrane soluble TNF receptor (sTNFR1) construct was expressed in hematopoietic cell lines. ER export was facilitated by addition of a transmembrane (tm) sequence, and constituti
Sodium stearoyl-2 lactylate (SSL) lipid surfactant molecules specifically bind partially hydrolysed oat proteins in aqueous medium and significantly enhance the dispersion stability of oat cereal preparations. The proposed complexation is composition dependent and a greater understanding of the role of both oat proteins and lipid surfactant in the effect was gained with data from high performance
Aim: To investigate the effect of general anaesthesia on the TCI-dosage, the depth of anaesthesia and the need for hemodynamic treatment. A comparison between general anaesthesia (GA) alone and general anaesthesia combined with epidural anaesthesia (GA+EDA). Background: There are some uncertainties in the literature whether epidural anaesthesia has any effect on general anaesthesia governed by Ta
The thesis studies the situation within Lund University in relation to the implementation of the European Standards and Guidelines (ESG) developed by The European Association for Quality Assurance in Higher Education (ENQA). The aim of the study is to answer the following research question “How have Lund University implemented the European Standards and Guidelines developed by The European Associa
Proton therapy has shown potential for reducing doses to normal tissues in breast cancer radiotherapy. However data on the impact of protons when including internal mammary nodes (IMN) in the target for breast radiotherapy is comparatively scarce. This study aimed to evaluate normal tissue doses when including the IMN in regional RT with scanned proton beams, with and without respiratory gating. T
Purpose: The substantial literature showing that offspring of parents with alcohol use disorder (AUD) is at increased risk for externalizing psychopathology rarely examines the differential effects of parental and offspring sex. This literature also has other important limitations, such as modest sample sizes and use of unrepresentative samples. Using a large, nationwide Swedish sample, we aim to
