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Alzheimer’s disease is a severe neurodegenerative disease, affecting the life of millions of patients and those who stand close to them. There is an urgent need for new effective medical treatments targeting this disease, as up to now, there is none. GPR3, a highly constitutively active orphan G protein coupled receptor, was found to interact with several different molecules that are known to play
Payment for water ecosystem services has been gaining attention in Latin America because of the direct response for environmental conservation through economic mechanisms. By connecting nature services with people who benefit from them, it creates a sustainable intervention for the ecosystem’s management while enhancing human well-being according to policy implementers. Nevertheless, these initiat
Moving towards circular economy is considered as a fundamental way to achieve sustainable development, but practices and tools that can support businesses in implementing this concept are still underdeveloped. Moreover, there is uncertainty about the impact that the adoption of circularity has on the current way of working of a company. With the adoption of aspects of action research on a rock and
Alongside global acknowledgements of the gendered nature of conflict, the academic field of transitional justice is shifting towards the newly emerging concept of transformative justice. Within this, reparations are particularly seen as the most agent-centric tool for structural transformation. In northeastern Nigeria, the conflict between Boko Haram and the state has seen a prevalence of conflict
Background and Objectives: This research explored the possibility of organisations implementing the work of CIP for the right beneficial reason, or if the implementation was done because the subject is a trend. While CIP-methods are getting more and more popular, it remains in many cases unclear which concepts suit best to what organisation. Having a single organisation implementing a numerous var
This research addresses the role of social capabilities over the growth trajectory of natural resource (NR) rich developing countries through a case study – an analytical narrative using data from various sources – of the Chilean experience since the early 1900s to the present. The paper adopts a novel framework, which identifies four distinct but interrelated dimensions of social capabilities: tr
As the world is becoming more digital, the use of data is rapidly increasing. To protect all EU citizens from privacy and data breaches, the regulations will become stricter. The General Data Protection Regulation (GDPR) will become effective on the 25th of May 2018. This will mean big structural changes for organizations, but it will also mean tougher requirements for gathering and maintaining pe
This paper studies the relationship between contraceptive adoption by women and three relevant predictors: women’s education, empowerment and religious affiliation. I employ recent information on women’s characteristics and the institutional environment for six Latin American countries, in the years 2013-2015, to perform a cross-section analysis with binary and multinomial logistic regressions, ha
Världen är för närvarande på väg mot 3°C av global uppvärmning pga globala koldioxidutsläpp. Kunskapen som krävs för att minska utsläppen existerar, men de radikala sociala och politiska förändringar som behövs sker hittills inte snabbt nog. Nuvarande politiska och ekonomiska paradigm hyllar koldioxidprissättning som antingen den enda lösningen, alternativt som en del av lösningen. Denna uppsats tThe world is currently heading for 3°C of global warming due to global excessive carbon emissions, and while science is producing the knowledge necessary to combat it, the radical change needed is not coming fast enough. Current political and economic paradigms hail carbon pricing as either the, or part of the solution to our carbon emissions problem. This thesis looks at the available (although l
Immunotherapy aims to enhance the immune system’s response to cancer. Different immunotherapies exist, such as cytokine therapies and immune checkpoint inhibitors. The FDA has approved immunomodulatory drugs, such as Proleukin, a recombinant IL-2 cytokine, Nivolumab, and Avelumab, which are immune checkpoint inhibitors. However, these drugs lead to side effects in patients known as immune-related
Pain upon negative pressure wound therapy (NPWT) dressing removal has been reported and is believed to be associ- ated with the observation that granulation tissue grows into foam. Wound tissue damage upon removal of the foam may cause the reported pain. Calcitonin gene-related peptide (CGRP) and substance P are neuropeptides that cause inflam- mation and signal pain and are known to be released w
Context. In 1992 we began a precision radial velocity survey for planets around solar-like stars with the Coude Echelle Spectrograph and the Long Camera (CES LC) at the 1.4m telescope in La Silla (Chile) resulting in the discovery of the planet iota Hor b. We have continued the survey with the upgraded CES Very Long Camera (VLC) and the HARPS spectrographs, both at the 3.6m telescope, until 2007.
A capillary-based model modified for characterization of monolithic cryogels is presented with key parameters like the pore size distribution, the tortuosity and the skeleton thickness employed for describing the porous structure characteristics of a cryogel matrix. Laminar flow, liquid dispersion and mass transfer in each capillary are considered and the model is solved numerically by the finite
The severe consequences of road tunnel fires have led researchers to investigate the best safety design methodology. Italy has the main tunnel network in Europe and consequently the importance of a definition of the optimal design standard is a key issue. This paper reviews the design of the means of egress from tunnels within the Italian Codes (analysing both prescriptive and performance-based ap
Background: Certain immune-mediated diseases (IMDs) have been associated with increased risk for cardiovascular disorders. The aim of the present study was to examine whether there is an association between 32 different IMDs and first hospitalization for ischemic or hemorrhagic stroke. Methods: All individuals in Sweden hospitalized with a main diagnosis of IMD (without previous or coexisting stro
A methodology based on Principal Component Analysis (PCA) and clustering is evaluated for process monitoring and process analysis of a pilot-scale SBR removing nitrogen and phosphorus. The first step of this method is to build a multi-way PCA (MPCA) model using the historical process data. In the second step, the principal scores and the Q-statistics resulting from the MPCA model are fed to the LA
In 2009, the European Paediatric Study Group for Haemolytic Uraemic Syndrome (HUS) published a clinical practice guideline for the investigation and initial therapy of diarrhea-negative HUS (now more widely referred to as atypical HUS, aHUS). The therapeutic component of the guideline (comprising early, high-volume plasmapheresis) was derived from anecdotal evidence and expert consensus, and the a
Commercial potato protein concentrate (PPC) was investigated as a source of thermoformed bio-based plastic film. Pressing temperatures of 100 to 190 degrees C with 15 to 25% glycerol were used to form PPC films. The shape of the tensile stress-strain curve in thermoformed PPC was controlled by glycerol level and was independent of processing temperature. Tensile testing revealed that elongation at
