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Interstitial photodynamic therapy for primary prostate cancer incorporating realtime treatment dosimetry

Photodynamic therapy (PDT) for the treatment of prostate cancer has been demonstrated to be a safe treatment option capable of inducing tissue necrosis and decrease in prostate specific antigen (PSA). Research groups report on large variations in treatment response, possibly due to biological variations in tissue composition and shortterm response to the therapeutic irradiation. Within our group,

Some consequences of atmospheric dispersion for ELTs

Previously the effect of atmospheric dispersion on telescope performance has attracted only relatively little attention. This may be due to the fact that the dispersion effects have been evaluated in relation to the size of the diffraction limited resolution angle of current telescopes, or to seeing limited telescopes. However, since the resolution angle is inversely proportional to telescope diam

A new concept for large deformable mirrors for extremely large telescopes

For extremely large telescopes, there is strong need for thin deformable mirrors in the 3-4 m class. So far, feasibility of such mirrors has not been demonstrated. Extrapolation from existing techniques suggests that the mirrors could be highly expensive. We give a progress report on a study of an approach for construction of large deformable mirrors with a moderate cost. We have developed low-cos

Rural-urban interdependencies : The role of cities in rural growth

A massive population growth in cities is currently being witnessed in most countries around the world. As urban populations grow, cities eventually expand geographically into what was considered countryside and nowadays distinguishing between what is city and what is countryside is getting increasingly difficult. In many Western countries, it is being observed that areas near cities seem to capita

Dysglycemia, glycemic variability, and outcome after cardiac arrest and temperature management at 33°C and 36°C

Objectives: Dysglycemia and glycemic variability are associated with poor outcomes in critically ill patients. Targeted temperature management alters blood glucose homeostasis. We investigated the association between blood glucose concentrations and glycemic variability and the neurologic outcomes of patients randomized to targeted temperature management at 33°C or 36°C after cardiac arrest. Desig

Biological predictors of insulin resistance associated with posttraumatic stress disorder in young military veterans

Posttraumatic stress disorder (PTSD) is associated with increased risk for Type 2 diabetes and cardiovascular disease (cardiometabolic disease), warranting research into targeted prevention strategies. In the present case–control study of 160 young (mean age 32.7 years) male military veterans, we aimed to assess whether PTSD status predicted increased markers of cardiometabolic risk in otherwise h

Implementation of the Trade Secrets Directive into National Law: Portugal and Spain

The protection of trade secrets in Portugal and Spain has been derived from general legal principles (of Civil Law, Penal Law and Unfair Marketing Law). This chapter on implementation of the Trade Secrets Directive (TS Directive) in Portugal and Spain presents the traditional views and positions and the implementation of the TS Directive into the respective national legal orders.In Portugal, imple

Recognizing Microscopic Structures: Dense Semantic Segmentation of Multiple Histopathological Classes using Fully Convolutional Neural Networks

In order to alleviate the financial burden on the healthcare sector as well as relax its employees’ workload, there is a need to introduce novel tools that automate some of the tasks that today are performed manually. Especially pathology poses a problem with few pathologists, demanding manual labour and unnecessary work on benign tissue. As a response, the DOGS project aims to develop a tool to a

How to age right and care(fully) at home? : A protocol for a multistage comparative study of ageing in place and hospital at home care across three countries

INTRODUCTION: Ageing right care(fully) is a transnational research study which explores and maps an understanding of the care pathways between ageing in place and hospital at home policy and practices for older adults in Israel, the Netherlands and Sweden. The countries are suited to be compared where they have growing, ageing populations, a focus on healthcare reform and several policies to reduc

Potential biomedical use of diode-laser-induced luminescence from upconverting nanoparticles

The intention with this chapter is to briefly review the capabilities made possible in the field of biomedical diagnostics and treatment by employing upconverting nanoparticles (UCNPs), as well as the importance of appropriate light sources for such applications. The field of UCNPs in biomedicine has grown rapidly the last decade, since they first were made sufficiently small and bright to be of r

Fading characterization of 73 GHz millimeter-wave V2V channel based on real measurements

In this work, a recently conducted measurement campaign for millimeter wave (mm-wave) vehicle to vehicle (V2V) propagation channel characterization is introduced. Two vehicles carrying a transmitter (Tx) and a receiver (Rx) respectively were driven towards each other at an average speed of 60 km/h in an urban area of Jiading District, Shanghai, China. The measurement was conducted with 409.6 MHz b

Cardiac arrest in COVID-19 : characteristics and outcomes of in- and out-of-hospital cardiac arrest. A report from the Swedish Registry for Cardiopulmonary Resuscitation

AIM: To study the characteristics and outcome among cardiac arrest cases with COVID-19 and differences between the pre-pandemic and the pandemic period in out-of-hospital cardiac arrest (OHCA) and in-hospital cardiac arrest (IHCA). METHOD AND RESULTS: We included all patients reported to the Swedish Registry for Cardiopulmonary Resuscitation from 1 January to 20 July 2020. We defined 16 March 2020

Extreme altitude changes between night and day during marathon flights of great snipes

Summary Several factors affect the flight altitude of migratory birds, such as topography, ambient temperature, wind conditions, air humidity, predation avoidance, landmark orientation, and avoiding over-heating from direct sunlight.1, 2, 3, 4, 5, 6 Recent tracking of migratory birds over long distances has shown that migrants change flight altitude more commonly and dramatically than previously t

Grounding Embodied Multimodal Interaction : Towards Behaviourally Established Semantic Foundations for Human-Centered AI : The 1st International Workshop on Knowledge Representation for Hybrid Intelligence (KR4HI 2022), part of International Conference on Hybrid Human-Artificial Intelligence (HHAI 2022), Amsterdam, The Netherlands, June 13-17, 2022

We position recent and emerging research in cognitive vision and perception addressing three key questions: (1) What kind of relational abstraction mechanisms are needed to perform (explainable) grounded inference --e.g., question-answering, qualitative generalisation, hypothetical reasoning-- relevant to embodied multimodal interaction? (2) How can such abstraction mechanisms be founded on behavi

Alchemy of the Edge: Genesis of a Vibrant Decentralized Node

This Master's thesis in Sustainable Urban Design investigates the critical transformation of urban peripheral areas. Framed by the concept of "Alchemy of the Edge," it focuses on Westraven, Utrecht—a historically industrial and fragmented site. The project explores how design can facilitate Westraven's "Genesis as a Vibrant Decentralized Node," contributing to a more re

An operator theoretic approach to the Riemann Hypothesis

In 2023 an operator theoretic approach to the Prime Number Theorem was introduced by Olsen. In this thesis this approach is examined and applied to give a new, operator theoretic, proof of a different version of the Prime Number Theorem and of the Prime Number Theorem for arithmetic progressions. This approach is then expanded and rearranged to focus on the approximation error in the Prime Number