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The Swedish Medical Products Agency (MPA) objects to the fact that we occasionally refer to one of its senior ex-employees by name. However, names of individual MPA assessors, FDA reviewers, and EMA rapporteurs and co-rapporteurs are reported in regulatory documents and are a matter of public record. In our paper we in no way suggest that regulatory decisions were left to individual reviewers or a
To escape competition at the dung pile, a ball-rolling dung beetle forms a piece of dung into a ball and rolls it away. To ensure an their efficient escape from the dung pile, the beetles rely on a celestial compass to move along a straight paths. Here, we analyzed the reliability of different skylight cues for this compass and found that dung beetles rely not only on the sun, but also on the skyl
Genome wide association studies (GWAS) identify susceptibility loci for complex traits, but do not identify particular genes of interest. Integration of functional and network information may help in overcoming this limitation and identifying new susceptibility loci. Using GWAS and comorbidity data, we present a network-based approach to predict candidate genes for lipid and lipoprotein traits. We
We propose a novel Bayesian network tool to model the probabilistic relations between a set of type 2 diabetes risk factors. The tool can be used for probabilistic reasoning and for imputation of missing values among risk factors. The Bayesian network is learnt from a joint training set of three European population studies. Tested on an independent patient set, the network is shown to be competiti
Understanding, monitoring and mitigating drought is a very difficult task as a consequence of the intrinsic nature of the phenomenon. In addition, assessing the impact of drought on ecosystems and societies is also a complex task, because the same drought severity may have different consequences in different regions and systems due to the underlying vulnerabilities. New technologies based on geosp
To report contemporary outcomes, and evaluate differences after thrombolysis for occluded endoprosthesis, bypasses and native artery occlusion in patients with lower limb ischemia.
CONTEXT: Prior research suggests that drug abuse (DA) is strongly influenced by both genetic and familial environmental factors. No large-scale adoption study has previously attempted to verify and integrate these findings. OBJECTIVE: To determine how genetic and environmental factors contribute to the risk for DA. DESIGN: Follow-up in 9 public databases (1961-2009) of adopted children and their
Instrumental analysis in metabolomics has proven to be a challenging topic due to metabolites having a wide spectrum of physiochemical properties and concentrations. The more conventional techniques in metabolomics include gas chromatography and liquid chromatography coupled with mass spectrometric (MS) detection. In most cases these techniques provide methods that are adequate for metabolomic res
Interactive web-GIS tools play an important role in determining disaster risk assessment which ultimately result in reduction of unexpected damages, cost and saves millions of lives. Disaster management practitioners largely benefited information at their disposal about location where possible incidents are eminent, anticipate the impact and project possible outcomes to help mitigate and organize
Hydrogenation is a universal reaction, which is widely used in industry and academy. However, the reaction is not easy to be studied in extreme conditions such as high temperature and high pressure. On top of that, using Raman spectroscopy to observe the reaction is not so customary. Due to these aspects, the experiment was carried out. During the working process, the degradation reaction was also
In mathematical education it is crucial to have a good teaching plan and to execute it correctly. In particular, this is true in the field of numerical analysis. Every teacher has a different style of teaching. This thesis studies how the basic material of a particular topic in numerical analysis was developed in four different textbooks. We compare and evaluate this process in order to achieve a
With sustainability at the forefront of many cities’ urban development plans, it is possible that sustainable polices are targeted to attract a certain group of inhabitants. Malmö, Sweden, has implemented changes in order to gain international recognition as a green city but has also been experiencing growing residential segregation. The presence of urban greening projects is a keystone to human h
The increased capacity of elementary particle accelerators raises the demand for the simulation data of the experiments. One of the bottlenecks in the simulations is the QCD color structure calculation, which is usually treated using non-orthogonal and overcomplete sets of bases. The computational cost could be decreased significantly if orthogonal bases, such as the multiplet bases, were used ins
This master thesis presents a qualitative model for performing a due diligence analysis of non- financial risks and their management, the DANFiRM model. The model includes a thinking process and a working procedure for identifying and evaluating the current non-financial risk exposure at the target enterprise and further required measures for altering risk exposure and risk management activities t
Metals play a key role as a cornerstone of our modern society; they are part of the most basic elements of our daily life and have been part of our lifestyles for millennia. Current trends of metal production point out that developing countries in order to attain a developed-countries consumption level will require 3-9 times the present metal stock per capita, yet their mining practices are far fr
Countries around the world are employing renewable energy policies to increase renewable electricity in their electricity mix. Trinidad and Tobago (T&T), located in the Caribbean, has endogenous sources of oil and natural gas and has not yet capitalised on sources of renewable energy. The country‟s electricity is currently dominantly generated from natural gas however the natural gas reserves
Extreme heat is a growing public health threat in tropical Africa, especially in Ghana where outdoor maximum daily temperatures (Tx) regularly exceed 35 °C. Vulnerability to heat is socially and economically differentiated, with pregnant women, young children, elderly people, and people with chronic health conditions most at risk. High proportions of these groups are found in hospitals, yet little
