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Parametric design systems serve as powerful assistive tools in the design process by providing a flexible approach for the generation of a vast number of design alternatives. However, contemporary parametric design systems focus primarily on low-level engineering and structural forms, without an explicit means to also take into account high-level, cognitively motivated people-centred design goals.
Human calcitonin (hCT) is an endogenous polypeptide commonly employed in treating bone resorption-related illnesses, but its clinical application is limited due to its high aggregation tendency. Metalloporphyrins are effective in suppressing amyloid fibrillation, positioning them as potential drug candidates for amyloidogenic disorders like Alzheimer's and type 2 diabetes. In this work, we investi
BACKGROUND: Self-reported mental stress is not consistently recognized as a risk factor for stroke. This prompted development of a novel algorithm for stress-phenotype indices to quantify chronic stress prevalence in relation to a modified stroke risk score in a South African cohort. The algorithm is based on biomarkers adrenocorticotrophic hormone, high-density lipoprotein cholesterol, high-sensi
Metachromatic leukodystrophy (MLD) is a fatal, progressive neurodegenerative disorder caused by biallelic pathogenic mutations in the ARSA (Arylsulfatase A) gene. With the advent of presymptomatic diagnosis and the availability of therapies with a narrow window for intervention, it is critical to define a standardized approach to diagnosis, presymptomatic monitoring, and clinical care. To meet the
This paper highlights the lives of Japanese and Korean subjects of Imperial Japan who were involved in opium production and circulation in Manchukuo. It discusses the dynamics, practices, and experiences of opium production and circulation. This paper provides a new reading of the diverse beneficiaries on the ground and of the opium industry in Manchukuo from the angles of production and circulati
Background: While shared decision making is a cornerstone of orthopedic care, orthopedic surgeons face challenges in tailoring their advice and expectation management to individual shoulder arthroplasty patients due to the lack of systematically summarized evidence-based knowledge. This systematic review aims to provide an overview of current knowledge on independent predictive effects of patient-
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the benefits and harms of clustering of care activities for promoting development and preventing morbidity in preterm infants.
Background: Preterm and low birth weight infants are at an early stage of development, and do not receive adequate maternal circadian signals. They are often cared for over prolonged periods of hospitalisation in neonatal intensive care units (NICU), where environmental circadian stimuli are lacking. Exposure to artificial light–dark cycles may stimulate the development of the circadian system and
Decarbonization policies require public support to be implemented and to remain in legislation. Examinations of public support for climate policies tend to focus on asmall number of policy instruments and/or use hypothetical instead of real policy proposals. Here, we address these criticisms by examining public support acrossfour distinct policy instruments– command-and-control, market-based, info
This study bridges occupational health and innovation management by proposing psychosocial safety climate (PSC) as a key precondition for employee-driven innovation (EDI). EDI emphasises employees’ unique potential to generate and implement innovative ideas, with conducive working conditions, particularly those supporting psychological health, being crucial. Using a mixed-method explanatory design
This document is created within the research project Nordic Fire and Rescue Services in the Twenty First Century (FIRE21). In this project, the fire and rescue services are seen as both governed by, and dependent on, formal and informal networks. A fundamental assumption in the research project is that efficient emergency management is dependent on efficient problem-solving in these networks. As a
This article addresses the issue of how Social Science and Humanities (SSH) researchers frame and argue relevance, where there are no explicit expectations to do so. It uses research project reports submitted to a Swedish research council, to distil and further analyze ‘relevance expressions’. These expressions illustrate some methodological differences along the lines of the long-standing distinc
Background: Despite the proven efficacy of telestroke in improving clinical outcomes by providing access to specialized expertise and allowing rapid expert hyperacute stroke management and decision-making, detailed operational evidence is scarce, especially for less developed or lower income regions. Aim: We aimed to map the global telestroke landscape and characterize existing networks. Methods:
In recent years increasing attention has been given to systematic comparison of theories ofconsciousness. Laudable practical projects have emerged in this regard, such as adversarialcollaboration and the development of databases lending themselves to comparisons of empiricalsupport for theories. In addition to the practical advances, theoretical advances have been made,such as a list of issues a
Taxa specific responses to climate warming may shape aquatic communities, dominance patterns, biotic interactions, and related ecosystem processes and functions. As climate warming effects on smaller zooplankton are less understood than larger zooplankton, we focused on rotifers to study their response to a future climate warming scenario in outdoor mesocosms. Our year-long experiment (14 July 202
Purpose: To analyse graft detachment rates after Descemet stripping automated endothelial keratoplasty (DSAEK) using surgeon-cut grafts and pre-cut grafts transported in different mediums. Methods: A retrospective study of graft detachment rates including 265 surgeries (240 patients) performed between 2019 and 2023. The DSAEK grafts were either surgeon-cut (n = 135) or pre-cut and transported in a
The demand for cost- and time-effective and customizable components for High Vacuum (HV) and Ultra-High Vacuum (UHV) systems has prompted exploration into the application of 3D-printing technology. This study investigates the viability of utilizing 3D-printed plastics in UHV environments by evaluating their outgassing properties. An extensive evaluation of 3D-printing materials was carried out, hi
Traffic related non-exhaust particulate sources and road dust are an increasingly important source for PM10 air pollution as exhaust sources are decreasing due to regulations. In the Nordic countries, the road dust problem is enhanced by use of studded tyres, causing increased road wear and winter road maintenance including gritting. Efforts to reduce road dust emissions requires knowledge on temp
