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Background: Genome-wide association studies (GWAS) have identified 94 common single-nucleotide polymorphisms (SNPs) associated with breast cancer (BC) risk and 18 associated with ovarian cancer (OC) risk. Several of these are also associated with risk of BC or OC for women who carry a pathogenic mutation in the high-risk BC and OC genes BRCA1 or BRCA2. The combined effects of these variants on BC

Using dynamic Monte Carlo and Brownian dynamics, we investigate a floating bond model in which particles can bind through mobile bonds. The maximum number of bonds (here fixed to 4) can be tuned by appropriately choosing the repulsive, nonadditive interactions among bonds and particles. We compute the static and dynamic structure factor (intermediate scattering function) in the vicinity of the gas

Diseases of the myoneural junction and muscle are disabling and some are life-threatening. Recent successes in the identification of the underlying genetic mechanisms have had profound implication for their diagnostics, treatment and classification. We define familial risks for siblings who were hospitalized for or deceased from diseases of the myoneural junction and muscle. A nationwide database

Biomarkers for early detection of ovarian tumors are urgently needed. Tumors of the ovary grow within cysts and most are benign. Surgical sampling is the only way to ensure accurate diagnosis, but often leads to morbidity and loss of female hormones. The present study explored the deep proteome in well-defined sets of ovarian tumors, FIGO stage I, Type 1 (low-grade serous, mucinous, endometrioid;

Improving urban liveability and prosperity is commonly set as a priority in urban development plans and policy around the world. Several annual reports produced by international consulting firms, media, and global agencies rank the liveability of cities based on a set of indicators, to represent the quality of life in these cities. The higher is the ranking, the more liveable is the city. In this

Den här studien undersökte effekter av en stresshanteringsintervention, som genomfördes med åtta elever på en svensk gymnasieskola under hösten 2015. Hypoteserna inför projektet var att interventionen som varade under åtta veckor skulle ha en positiv effekt på användandet av adaptiva copingstrategier samt reducera upplevd stressnivå och öka självskattad hälsa. De utfallsmått som användes var PerceThis study examined the effects of a stress management intervention that was carried out with eight Swedish high school students (Swedish gymnasium) during the fall semester of 2015. The hypotheses were that the eight week intervention would have a positive impact on the usage of adaptive coping strategies, reduce perceived stress for the participants and increase self-estimated overall health. Th

The aim of this project was to determine the consequences of the large-scale introduction of wood-based biofuels in the road transport sector. Therefore a model has been developed to project the demand for wood in Sweden in the period from 2007 to 2050. The wood-using sectors that were taken into account are: the sawmill industry; the paper and pulp industry, which was split in three: integrated c

Horisonter med subfossila stubbar och rötter av tall (Pinus sylvestris) är vanliga i stratigra-fier från torvmarker i norra Europa. Dessa är tydliga indikationer på att det under holocen funnits perioder med tillräckligt gynnsamma förhållanden för tallar att växa på mossar. Tall kan endast växa på mossar när ytan är tillräckligt torr, och därför är rester av tallar på mossar goda indikationer på eHorizons rich in subfossil stumps and roots of Scots pine (Pinus sylvestris) are frequently found in stratigraphies of northern European peatlands, providing clear evidence of Holocene periods with favourable conditions for bog-pine growth. The pines could only grow when bog-surface wetness was sufficiently low, and the presence of their remains is therefore a good indicator of past climatic condi

Although novel treatment strategies based on the gene therapy approach for epilepsy has been encouraging, there is still a gap in demonstrating a proof-of-concept in a clinically relevant animal model and study design. In the present study, a conceptually novel framework reflecting a plausible clinical trial for gene therapy of temporal lobe epilepsy was explored: We investigated (i) whether the p

The potential effects of altering primary settlers during biological in-line hydrolysis and converting a nitrifying activated sludge process into a partial pre-denitrification process for the purpose of resource conservation were evaluated. A full-scale primary sludge hydrolysis experiment was performed at a wastewater treatment plant and implemented in a dynamic modelling tool based on ASM2d. The

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Medical education seemingly immune to discussions of gender. Study indicates gender perspective in teaching is lacking Maria Norstedt, Karen Davies Läkartidningen 2003:100;2056-62 This article builds upon qualitative interviews with teachers and students in the medical education at Lund university. The results found that a gender perspective is understood primarily in terms of the biological body.

Radiotherapy (RT) datasets can suffer from variations in annotation of organ at risk (OAR) and target structures. Annotation standards exist, but their description for prostate targets is limited. This restricts the use of such data for supervised machine learning purposes as it requires properly annotated data. The aim of this work was to develop a modality independent deep learning (DL) model fo

This research presents blogs as an innovative and rich tool for political communication. Blogs can facilitate two-way communication and true interaction between citizens and politicians. The article analyses in depth the content,uses, and characteristics of five weblogs written by Aragonese politicians. Although the study detects some weaknesses in the current political use of blogs, it encourages

Background: For up to 50% of adolescents experiencing PTSD, the course of their illness is further complicated by co-occurring substance use. Despite this, evidence-based integrated treatment options for adolescents with this comorbidity remain sparse. To address this gap, we are conducting an RCT examining the efficacy of exposure-based therapy for co-occurring PTSD and substance use among adoles

Education is seen as a protective factor for refugee children (Gunton, 2007; Block et al., 2014). Evidences from countries with an extensive experience on refugee education show that the ability of schools to provide immediate and appropriate support is pivotal in order to favour a smooth accommodation process and ensure settlement, safety, and security for children (Bash, 2006; Porche et al. 2011