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The European Union (EU) and the United States (US) often use different foreign policy strategies. In their non-proliferation policies they have had somewhat different approaches towards the suspected proliferators. In this thesis the usefulness and effectiveness of these different strategies, containment and engagement, are studied within the question of non-proliferation of Weapons of Mass Destr
In this paper the trade of virtual items in online games for hard currency is analysed using economic theory. There are real welfare gains from trade but the game designer’s interests must be taken into account when deciding whether trade is desirable or not. Ricardo's Comparative Advantage and Hecksher-Ohlin Factor Proportion theories lead to conclusions about game design when trade is free.
Nanoteknik är ‘big business’. Stora summor pengar står på spel då detta innovativa teknikområde expanderar i snabb takt. Denna undersökning utgår från antagandet att ekonomiska intressen snarare än demokratiska värden och hållbar utveckling styr utvecklingen av nanoteknik i Sverige idag. Detta ses som problematiskt, och det övergripande målet är att föreslå alternativa principer för att styra utveNanotechnology is big business. With rapid innovation and expansion of the field, financial stakes are high. This study is based on the assumption that the development of nanotechnology in Sweden today is controlled by economic interests rather than democratic values and sustainable development. This is considered problematic, and the overall aim with this study is to propose alternative principle
A considerable part of world merchandise is transported by sea, and with about 150,000 crew members working on the ship types of interest for this thesis there is much at stake if an accident occurs, both with respect to human lives and financial losses. Since fires have previously shown to be responsible for many accidents with severe consequences, the aim of this thesis has been to investigate t
The paper describes a theoretical analysis of programming and what it offers in terms of the meaning-making process. It finds that programming provide opportunity to iterate, to visualise and to perform transductions. Each affordance has been shown to affect the meaning-making process and can enhance it if used in a meaningful way. By using variation theory as a lens of these affordances, we ident
Background: Limited scientific evidence for prevention and treatment of diabetic foot ulcers in elderly with comorbidities. Aim: To explore patient-related factors and outcomes in patients ≥75 years with diabetes and a foot ulcer. Method: Sub-analysis of consecutively presenting patients ≥75 years (N = 1008) from a previous study on 2,480 patients with diabetic foot ulcer treated in a multidiscipl
Compact city planning and development has, over the last 30 years or so, been the hegemonic response to the challenges of sustainable development. Global and local policies promote the compact city model due to the positive outcomes of its design principles and strategics as to achieving sustainable cities in terms of their environmental, economic, and social goals. The aim of this paper is to exa
Background: Heterogeneity of prostate cancer (PCa) contributes to inaccurate cancer screening and diagnosis, unnecessary biopsies, and overtreatment. We intended to develop non-invasive urine tests for accurate PCa diagnosis to avoid unnecessary biopsies. Methods: Using a machine learning program, we identified a 25-Gene Panel classifier for distinguishing PCa and benign prostate. A non-invasive t
Background: Umbilical and epigastric hernia repairs are frequently performed surgical procedures with an expected low complication rate. Nevertheless, the optimal method of repair with best short- and long-term outcomes remains debatable. The aim was to develop guidelines for the treatment of umbilical and epigastric hernias. Methods: The guideline group consisted of surgeons from Europe and North
BACKGROUND: Brevican and neurocan are central nervous system-specific extracellular matrix proteoglycans. They are degraded by extracellular enzymes, such as metalloproteinases. However, their degradation profile is largely unexplored in cerebrospinal fluid (CSF).OBJECTIVE: The study aim was to quantify proteolytic peptides derived from brevican and neurocan in human CSF of patients with Alzheimer
Aim: To improve consistency between register studies in Sweden and ensure valid comparisons of possible changes in alcohol-related disorders and diseases (ARDDs) over time, we propose a definition of ARDDs. Based on this definition, we examined Sweden’s incidence rates of ARDDs from 1970 to 2018 in non-primary healthcare settings (inpatient and outpatient). Methods: Swedish Society of Epidemiology
Climate change is expected to severely affect cropping systems and food production in many parts of the world unless local adaptation can ameliorate these impacts. Ensembles of crop simulation models can be useful tools for assessing if proposed adaptation options are capable of achieving target yields, whilst also quantifying the share of uncertainty in the simulated crop impact resulting from th
The standard therapy for patients with haemophilia is prophylactic treatment with replacement factor VIII (FVIII) or factor IX (FIX). Patients who develop inhibitors against FVIII/FIX face an increased risk of bleeding, and the likelihood of early development of progressive arthropathy, alongside higher treatment-related costs. Bypassing agents can be used to prevent and control bleeding, as well
The direct involvement of S100 calcium-binding proteins A8 (S100A8) and A9 (S100A9) in numerous human diseases have been discovered more than 20 years ago, and they have ever since emerged as a very potent biomarker. Increased levels of S100A8 and S100A9 have been found in inflammation and various cancers. As complexes, they become crucial danger signals and act as endogenous activators of TLR4 (T
Den inre strukturen och vävnaden hos ben ger information om livsstil hos nutida och utdöda djur. Mosasaurier (familj Mosasauridae) är en grupp sekundärt anpassade marina reptiler som utvecklades och spred sig under sen krita, vilket resulterade i en kropp väl anpassad för marina miljöer. Marina anpassningar hos den här gruppen kan observeras på olika nivåer i skelettanatomin, exempelvis mikrostrukThe inner bone architecture and histology provide information about life history traits of extant as well as extinct animals. Mosasaurs (family Mosasauridae) are a group of secondarily adapted marine squamates that radiated in the Late Cretaceous, resulting in the evolution of a body plan adapted for pelagic habitats. Specialisa-tions in this group can be observed at different levels of skeletal a
Non proliferation is an issue of the utmost importance. It might seem that it is an issue more at home in the era of the cold war, however it is very much an issue of the 21th century. Countries like North Korea have not just pursued a policy of acquiring nuclear weapons but succeeded. How to best prevent countries from developing nuclear weapons is a question with no good answer. In the case of N
This study analyzed direct and indirect relationships in water consumption by Macedonian economic sectors using virtual water in an input–output framework. Macedonia was found to be characterized by intensive water consumption, with some sectors having a significant virtual water content in their products. Virtual water multipliers were used to analyze the trade balance and determine whethernation
Deciding the optimal project scope that fulfills the needs of the most important stakeholders is challenging due to a plethora of aspects that may impact decisions. Large companies that operate in rapidly changing environments experience frequently changing customer needs which force decision makers to continuously adjust the scope of their projects. Change intensity is further fueled by fierce ma
Pseudomyxoma Peritonei (PMP) is a rare peritoneal malignancy, most commonly originating from a perforated epithelial tumour of the appendix. Given its rarity, randomized controlled trials on treatment strategies are lacking, nor likely to be performed in the foreseeable future. However, many questions regarding the management of appendiceal tumours, especially when accompanied by PMP, remain unans
