Filetype
Animals live in diverse environments and have evolved to cope with environmental challenges in different ways. How such adaptations shape overall brain morphology is still unclear. Here, we test how two behavioural adaptations – circadian activity pattern and migratory behaviour – are reflected in the brains of moths and butterflies (Lepidoptera). We predicted that circadian activity pattern affec
Smart microscopy is transforming life sciences by automating experimental imaging workflows and enabling real-time adaptation based on feedback from images and other data streams. This shift increases throughput, improves reproducibility, and expands the functional capabilities of microscopes. However, the current landscape is highly fragmented. Academic researchers often develop custom solutions
Transient activation of fibroblasts into contractile myofibroblasts is essential for extracellular matrix (ECM) production and remodeling during wound healing and tissue regeneration. While ECM-dependent mechanisms mediating transient activation is well studied, how fibroblasts switch from transient to a persistently activated state and drive fibrosis and aberrant tissue repair in diseases such as
Group A Streptococcus (GAS) causes extensive global morbidity and rising rates of invasive disease, for which clinical outcomes remain poor despite antibiotic treatment of susceptible strains. This limitation of current therapy underscores the need for alternative or adjunctive approaches. Antibody-based interventions represent a promising but underexplored strategy. Historically, the streptococca
Objectives: To evaluate a cancer detecting artificial intelligence (AI) algorithm on serial biopsies in patients with prostate cancer on active surveillance (AS). Patients and methods: A total of 180 patients in the Prostate Cancer Research International Active Surveillance (PRIAS) cohort were prospectively monitored using pre-defined criteria. Diagnostic and re-biopsy slides from 2011 to 2020 (n
• We aimed to capture possible insights from an AI diagnosing without human guidance.• We believe the result mainly aligns with previous knowledge. Though, vital signs and sex did not aid the AI diagnostics.
The seasonal migrations of insects involve a substantial displacement of biomass with significant ecological and economic consequences for regions of departure and arrival. Remote sensors have played a pivotal role in revealing the magnitude and general direction of bioflows above 150 m. Nevertheless, the take-off and descent activity of insects below this height is poorly understood. Our lidar ob
The recently developed Phase-Scaled Reassignment (PSR) can estimate phase-difference between two oscillating transient signals with high accuracy. However, in low signal-to-noise ratios (SNRs) the performance of commonly applied reassignment techniques is known to deteriorate. In order to reduce variance in low SNR, we propose a multitaper PSR (mtPSR) method for phase-difference estimation between
Coherence is a useful measure in many engineering applications. Here, we focus on the case where the input signal to a linear system can be measured free from noise, but the output signal is perturbed by noise. A novel expression for the expectation of a multitaper magnitude squared coherence estimate for this case is presented and verified through numerical evaluation. Additionally, the expressio
Time-frequency reassignment, commonly used to analyze time-varying signals, is a post-processing method that sharpens time-frequency representations. However, the reassignment method is sensitive to noise, making it unsuitable for time-frequency analysis when the signal-to-noise ratio is low. To increase the robustness of the reassignment technique, we develop a novel reassigned multitaper spectro
In the literature, auditory attention is explored through neural speech tracking, primarily entailing modeling and analyzing electroencephalography (EEG) responses to natural speech via linear filtering. Our study takes a novel approach, introducing an enhanced coherence estimation technique to assess the strength of neural speech tracking. This enables effective discrimination between attended an
Lipid nanoparticles (LNPs) are clinically approved for mRNA-based vaccines and liver-targeted siRNA delivery. However, poor nucleic acid delivery efficiency limits their application in extrahepatic tissues and tumors. Here, using live-cell and super-resolution microscopy, we identify multiple distinct steps of inefficiencies in the cytosolic delivery of both siRNA and mRNA cargoes. Membrane damage
We present the artillery of a well-preserved late medieval Danish-Norwegian carvel warship, Gribshunden. Probably built in the Netherlands in 1484, the ship served King Hans until sinking in June 1495. Of its original 50 or more guns, elements of 11 have been recovered and digitally recreated, and more remain on the wreck. Investigation of this site provides insights into the development of shipboWe present the artillery of a well-preserved late medieval Danish-Norwegian carvel warship, Gribshunden. Probably built in the Netherlands in 1484, the ship served King Hans until sinking in June 1495. Of its original 50 or more guns, elements of 11 have been recovered and digitally recreated, and more remain on the wreck. Investigation of this site provides insights into the development of shipbo
Introduction: Diabetic peripheral neuropathy (DPN) is a common complication of both type 1 (T1D) and type 2 diabetes (T2D). No cure for DPN is available, but several potential targets have been proposed for treatment. Heat shock proteins (HSPs) are known to respond to both hyper- and hypoglycemia. DPN can be diagnosed using electrophysiology and studied using peripheral nerve biopsies.Aim: This st
Nanoplastics have been proven to induce toxicity in diverse organisms, yet their effect on soil microbes like bacteria and fungi remains largely unexplored. In this paper, we used micro-engineered soil models to investigate the effect of polystyrene (PS) nanospheres on Pseudomonas putida and Coprinopsis cinerea. Specifically, we explored the effects of increasing concentrations of 60 nm carboxylat
We have used a continuous-wave bi-static lidar system based on the Scheimpflug principle in measurements on flying insects above, and in the vicinity of, a small lake located in a forested area in Southern Sweden. The system, which operates on triangulation principles, has a high spatial resolution at close distance, followed by a subsequent decline in resolution further from the sensor, related t
The great variety of earth's microorganisms and their functions are attributed to the heterogeneity of their habitats, but our understanding of the impact of this heterogeneity on microbes is limited at the microscale. In this study, we tested how a gradient of spatial habitat complexity in the form of fractal mazes influenced the growth, substrate degradation, and interactions of the bacterial st
