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At least 17 genomic regions are established as harboring melanoma susceptibility variants, in most instances with genome-wide levels of significance and replication in independent samples. Based on genome-wide single nucleotide polymorphism (SNP) data augmented by imputation to the 1,000 Genomes reference panel, we have fine mapped these regions in over 5,000 individuals with melanoma (mainly from

Hereditary syndromes causing colorectal cancer include both polyposis and non-polyposis syndromes. Overlapping phenotypes between the syndromes have been recognized and this make targeted molecular testing for single genes less favorable, instead there is a gaining interest for multi-gene panel-based approaches detecting both SNVs, indels and CNVs in the same assay. We applied a panel including 19

Failure of the human heart to maintain sufficient output of blood for the demands of the body, heart failure, is a common condition with high mortality even with modern therapeutic alternatives. To identify molecular determinants of mortality in patients with new-onset heart failure, we performed a meta-analysis of genome-wide association studies and follow-up genotyping in independent populations

The Benguela Upwelling System (BUS), located between 30 and 20°S, is one of the fundamental high-productivity systems of the world ocean. The BUS has previously been studied in terms of primary productivity and ecology over glacial-interglacial timescales; however, the response and coupling with the benthic environment have received little attention. Here, for the first time, we present a high-res

UNLABELLED: Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest GWA meta-analysis data sets for these cancers totaling 112,349 cases and 116,421 controls of European ancestry, all together and in pairs, identified at P < 10(-8) s

We examined the associations between germline variants and breast cancer mortality using a large meta-analysis of women of European ancestry.

Background: The transcription factor signal transducer and activator of transcription 3 (STAT3) is implicated in cancer drug resistance, metastasis, and immunosuppression and has been identified as a promising therapeutic target for new anticancer drugs. Myeloid-derived suppressor cells (MDSCs) play a major role in the suppression of antitumor immunity and STAT3 is involved in the accumulation, ge

Höksångarens Sylvia nisoria flyttning och övervintring Fåglars flyttning har fascinerat forskare under en lång tid. Från att ha varit begränsat till visuella observationer har utvecklingen tagit forskningsfältet framåt via bland annat ringmärkning, radar, satellit- och GPS-sändare. Det senaste decenniet har mycket små ljusmätande apparater gjort det möjligt att detaljerat följa även mindre fåglarTechnological advancements in the past few decades have been pushing the research field of animal migration forward rapidly. In this study light-level geolocators were used to track Swedish barred warblers Sylvia nisoria, a long-distance migrant wintering in equatorial East Africa. We obtained data on autumn migration events and on wintering sites. Ringing data from populations in Northern Europe

Under åren 1965-1974 genomfördes en omfattande bostadsproduktion i Sverige som betecknas miljonprogrammet. Då byggdes en miljon bostäder runtom i landet. Idag finns behov av att renovera dessa bostäder. I samband med det kan energisparåtgärder genomföras för att minska energianvändningen. Detta kan uppfyllas genom att åtgärda otäta väggar och byta ut äldre fönster som medför oönskade värmeförlusteIn order to maintain a good indoor environment, air pollutants such as moisture need to be removed by the ventilation. Among the Swedish Public Health Agency's general advices for ventilation and indoor environment, 3 g/m3 is a guideline value for moisture excess during winter months to not pose a risk to human health. The indoor climate parameters moisture excess, relative humidity and air va

Svenska, språklig inriktning 1–40 poäng Vårterminen 2017 Litteraturlista för SVEM40, Nordisk språk- variation, 7,5 högskolepoäng Fastställd av sektion 1 vid Språk- och litteraturcentrum den 7 december 2016. Obligatorisk litteratur Dahl, Östen. 2004. Definite articles in Scandinavian: Competing grammaticalization processes in standard and non-standard varieties. I Bernd Kortmann (red.) Dialectology

https://www.sol.lu.se/media/utbildning/dokument/kurser/SVEM30/20171/SVE_M40_Litteraturlista.pdf - 2026-06-02

Nanowires are presently investigated in the context of various biological and medical applications. In general, these studies are population-based, which results in sub-populations being overlooked. Here, we present a single cell analysis of cell cycle and cell movement parameters of cells seeded on nanowires using digital holographic microscopy for time-lapse imaging. MCF10A normal-like human bre

Background: It is not known whether stromal cells in benign breast tissue can mediate risk of breast cancer. We recently described aldehyde dehydrogenase 1 A1 (ALDH1) positive (+) cells in morphologically normal breast stroma of premenopausal women, and the data indicated that their distribution is associated with clinical risk factors for breast cancer. The aim of the present study was to define

Vår undersökning har följt den svenske rapartisten Einár genom hans karriär. Vi har observerat olika händelser som han har uppmärksammats för, som att han har vunnit pris, att han har blivit kidnappad och rånad, och att han slutligen har blivit skjuten och avled till följd av en skottlossning. Källorna som används är diverse artiklar från SVT Nyheter (som finansieras av public service). I vår anal

Objective: The aim of this study was to evaluate the association of self-assessed preoperative physical activity, alcohol consumption and smoking with self-assessed quality of life, negative intrusive thoughts and depressed mood after radical prostatectomy. Materials and methods: The Laparoscopic Prostatectomy Robot Open (LAPPRO) trial was a prospective, controlled, non-randomized longitudinal tri

Background/Aims: Inguinal incisions are a common route of access in vascular surgery. Due to anatomical challenges and a diverse bacterial flora in this area, surgical site infections (SSI) represent a common, debilitating and sometimes life-threatening complication. The INVIPS-Trial evaluates the role of Negative Pressure Wound Therapy (NPWT) on closed inguinal incisions in elective vascular surg

In the advanced stages, malignant melanoma (MM) has a very poor prognosis. Due to tremendous efforts in cancer research over the last 10 years, and the introduction of novel therapies such as targeted therapies and immunomodulators, the rather dark horizon of the median survival has dramatically changed from under 1 year to several years. With the advent of proteomics, deep-mining studies can reac