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Smad5 is known to transduce intracellular signals from bone morphogenetic proteins (BMPs), which belong to the transforming growth factor-beta (TGF-beta) superfamily and are involved in the regulation of hematopoiesis. Recent findings suggest that BMP4 stimulates proliferation of human primitive hematopoietic progenitors in vitro, while early progenitors from mice deficient in Smad5 display increa
Label-free LC-MS methods are attractive for high-throughput quantitative proteomics, as the sample processing is straightforward and can be scaled to a large number of samples. Label-free methods therefore facilitate biomarker discovery in studies involving dozens of clinical samples. However, despite the increased popularity of label-free workflows, there is a hesitance in the research community
Calcitonin gene-related peptide (CGRP) research was initiated by Poyner et al.,(1) who found that the calcitonin gene encodes the 37-amino acid neuropeptide CGRP in neuronal tissue. Within months, the Lund group produced antibodies toward α-CGRP and developed sensitive methods to study the role of this peptide in the cranial circulation. Intracranial vessels and the trigeminal ganglion harbor this
Sustainable development requires coordination among multi-level actors to achieve set targets, with networks playing a key role in sharing knowledge and fostering collective actions. These networks’ success hinges on member engagement, but since participation is voluntary, members choose their level of involvement. Despite the importance, factors influencing network engagement remain rather scarce
Granule neurons of the dentate gyrus (DG) of the hippocampus undergo continuous renewal throughout life. Among cell cycle regulators, cyclin-dependent kinase 2 (Cdk2) is considered as a major regulator of S-phase entry. We used Cdk2-deficient mice to decipher the requirement of Cdk2 for the generation of new neurons in the adult hippocampus. The quantification of cell cycle markers first revealed
Revised simulation theory (Goldman, 2006) allows mental state attributions containing some or all of the attributor’s genuine, non-simulated mental states. It is thought that this gives the revised theory an empirical advantage, because unlike theory theory and rationality theory, it can explain egocentric bias (the tendency to over attribute ones’ own mental states to others). I challenge this vi
Background: Under inflammatory conditions, T cell-dependent (TD) protein antigens induce proinflammatory T-and B-cell responses. In contrast, tolerance induction by TD antigens without costimulation triggers the development of regulatory T cells. Under both conditions, IgG antibodies are generated, but whether they have different immunoregulatory functions remains elusive. Objective: It was shown
This research explores young mothers' usage of social media to obtain child-rearing information in mainland China. I interviewed 11 Chinese women with the different background of their everyday social media practices. Through analyzing of their interpretation, the research displays one facet of mediated society, that is how social media influences young Chinese mothers in different aspects, sh
The fast development of computational power of the mobile phone makes it a suitable platform for running map applications. Both public and field working professionals can benefit from easy access to a mobile map client application with features such as route planning, location based services and simple GIS operations. This master's thesis describes the mobile operating system (OS) Android from
On 31 January 2018, the Danish Competition and Consumer Authority adopted a decision that found the Swedish company CD Pharma, a generic distributor, to be in breach of Article 102(a) TFEU due to having abused its dominant position and imposed excessive and unfair prices for the drug Syntocinon. The company had increased the price of the drug by 2000% on the Danish market in the period April 2014-
The title compound forms as biphasic single crystals containing the α- and β-polymorphs. The structure of both polymorphs was solved and refined from single crystal X-ray data in a simultaneous refinement. The structures consist of rods of composition Sb3O4 separated by isolated iodine ions. The two phases differ only in the next nearest neighbour arrangement. The orthorhombic α-phase crystallizes
The Romanian healthcare system faces various structural issues such as corruption, underfunding, and lack of modernization. As hospitals make every effort to cope with the COVID-19 pandemic around the country, there have been two deadly hospital fires. This study strives to reconstruct and evaluate Romanian President Klaus Iohannis’ arguments given in favor of health reform in response to the two
