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INTRODUCTION: Hospital-acquired bloodstream infections (HA-BSIs) are severe and require antibiotic therapy. In non-complicated BSIs, shortened therapy reduces side effects without compromising efficacy. The impact of shortened antibiotic therapy in HA-BSI critically ill patients without indication of prolonged therapy requires further evaluation. METHODS: Using the international prospective EUROBA
The objective of this investigation was to explore a hybrid application of Structural Equation Modelling (SEM) and Fuzzy-set Qualitative Comparative Analysis (FsQCA) to assess the impact of safety-related behavioural traits on the performance of bicyclists using a limited sample of data as a case study. These behavioural characteristics of cyclists are fundamental when specific cyclist groups are
Two major debates frame Arctic prehistory: the emergence of specialized maritime economies that support sedentism and growing socio-political complexity, and the role of these economies in the transition from Paleo-Inuit to Neo-Inuit traditions. This shift, originating in the Bering Strait, led to Thule Inuit dispersal across the Arctic, impacting Indigenous communities today. However, understandi
In Memoriam
Background: After an older person moves into a nursing home, the next of kin often continues to participate in the care provided there. This participation in care may contribute valuable knowledge of the preferences and wishes of the older person, thereby helping nursing staff deliver personalised care. Objectives: The aim of this study was to explore how next of kin experience their participati
Background: We investigated the impact of time to adjuvant chemotherapy (AC) on survival after surgical resection (<8 weeks or 8–16 weeks) for patients with non-small cell lung cancer (NSCLC) by applying a target-trial emulation. Material and Methods: We used Swedish population-based healthcare registries to emulate a hypothetical target trial, with treatment arms of ‘initiate AC <8 weeks postoper
University students’ conceptions of differentiability, continuity and relationsbetween these concepts were studied to reveal their choices of representationsand their strategies to justify their relational claims. Questionnaires and interviews were used to collect data. The results were analysed and categorizedthrough a framework based on understanding as connections between concepts,and a theory
Objective: We compared the accuracy of amyloid and [18F]Flortaucipir (FTP) tau positron emission tomography (PET) visual reads for distinguishing patients with mild cognitive impairment (MCI) or dementia with fluid biomarker support of Alzheimer's disease (AD). Methods: Participants with FTP-PET, amyloid-PET, and diagnosis of dementia-AD (n = 102), MCI-AD (n = 41), non-AD diseases (n = 76), and co
This essay argues that an important factor behind the emergence of a rabbinic form of Judaism was a challenge to Jewish identity and self-understanding posed by Jesus-oriented groups who had appropriated essential aspects of Jewish self-understanding. The unease with gentile attachment to Israel’s God and involvement with the Torah, and the reconfiguration of the boundaries of Judaism to exclude J
Pharmaceutical companies spend hundreds of millions of pounds on marketing/R&D-related payments annually to healthcare organisations and healthcare professionals. UK pharmaceutical industry self-regulatory bodies require member companies who sign up to their code of conduct to publish details of their payments. They are also required to publish the methodologies underlying these payments, name
Biografisk skiss rörande den av allt att döma förste lundastudenten av delvis utomeuropeisk härkomst, Hans Wilhelm Lindstedt (c:a 1759-?) med anledning av 250-årsminnet av hans inskrivning.
The modified sample-standard bracketing method (m-SSB) combines a sample-standard bracketing and an inter-element correction procedure to account for instrumental mass fractionation during multi-collector ICP-MS measurements. Precisions for Cu and Zn isotopes in plant and experimental granite leachate samples are in line with those obtained using other mass bias correction techniques. In addition,
We present a new instrument, "Boreas", a cryogen-free methane (CH4) preconcentration system coupled to a dual-laser spectrometer for making simultaneous measurements of δ13C(CH4) and δ2H(CH4) in ambient air. Excluding isotope ratio scale uncertainty, we estimate a typical standard measurement uncertainty for an ambient air sample of 0.07‰ for δ13C(CH4) and 0.9‰ for δ2H(CH4), which are the lowest r
Background Use of artificial intelligence (AI), or machine learning, to assess dermoscopic images of skin lesions to detect melanoma has, in several retrospective studies, shown high levels of diagnostic accuracy on par with - or even outperforming - experienced dermatologists. However, the enthusiasm around these algorithms has not yet been matched by prospective clinical trials performed in auth
The chapter examines what peace looks like from the working levels of the Nordic countries. Several researchers have proclaimed a common Nordic approach to peace and conflict resolution “dead”. However, through interviews focusing on the working level, we find that the Nordics in fact work very closely together in practice, especially in the field in conflict-affected areas. This work is generally
Combined CDK4/6 inhibitor (CDK4/6i) and endocrine therapy significantly improves outcome for patients with estrogen receptor-positive (ER+) metastatic breast cancer, but drug resistance and thus disease progression inevitably occur. Herein, we aimed to identify genomic alterations associated with combined CDK4/6i and endocrine therapy resistance, and follow the levels of specific mutations in long
BACKGROUND: Symptom reduction occurring early in depression treatment is associated with favourable post-treatment outcome, but it is not known how early reduction in specific depression symptoms affect treatment outcome. We aimed to determine the impact of symptom-specific change from pre-treatment to week four during internet-delivered CBT (ICBT) on overall and symptom-specific depression severi
Purpose: Etoposide to standard R-CHOP is used for high-risk diffuse large B-cell lymphoma (DLBCL) in some countries. Due to the lack of randomized trials, a real-world data study using matching methods was used to test the potential effectiveness of R-CHOEP over R-CHOP. Patients and Methods: This study included patients from the Danish Lymphoma Register diagnosed between 2006 and 2020 at the age o
Epigenetic deregulation through altered DNA methylation is a fundamental feature of tumorigenesis, but tumor data from bulk tissue samples contain different proportions of malignant and non-malignant cells that may confound the interpretation of DNA methylation values. The adjustment of DNA methylation data based on tumor purity has been proposed to render both genome-wide and gene-specific analys
