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In the novel and promising radiotherapy technique known as FLASH, ultra-high dose-rate electron beams are used. As a step towards clinical trials, dosimetric advances will be required for accurate dose delivery of FLASH. The purpose of this study was to determine whether a built-in transmission chamber of a clinical linear accelerator can be used as a real-Time dosimeter to monitor the delivery of
As climate models can be used to reproduce historical climates, the outcomes can be used to put climate extremes in to a proper historical perspective. This also allows investigation of nonlinear properties of hydrologic processes (e.g. precipitation, runoff) to better understand regional hydrologic dynamics. To this end, the present study uses results from a so-called 'paleosimulation' (i.e. simu
Background: Newborns, admitted to the Neonatal Intensive Care Unit (NICU), are exposed to a large number of medications, the majority of which are not labeled for use in infants, especially in preterm newborns, because clinical trials on their benefits and harms are lacking. There is a huge gap in knowledge on pharmacokinetic (PK) data in sick preterm infants, including that of drug penetration to
Hereditary deficiencies of protein S (PS) increase the risk of thrombosis. However, assessing the plasma levels of PS is complicated by its manifold physiological interactions, while the large inter-individual variability makes it problematic to establish reliable cut-off values. PS has multiple physiological functions, with only two appearing to have significant anticoagulant properties: the acti
Microbunching instability (MBI) has been one of the most challenging issues in designs of high-brightness beam transport lines for single-pass or recirculating accelerators. Although the intrabeam scattering (IBS) has long been studied in lepton or hadron storage rings as a slow diffusion process or in high-intensity proton linear accelerators as one mechanism for the beam halo, the effects of IBS
The modelling of biological systems often consists into differential equation models that need to be fitted to experimental data. During this complex process, the practical experience of the biologist and the theoretical abstraction of the modeller require back-and-forth refinements of the model, design of new experiments and inclusion of more data-points into the fitting procedure. Available opti
Purpose: Prolonged stress leading to sick leave is a serious health problem, and it is crucial to find ways to support recovery. The aim of this review was to synthesize the results from qualitative research about what people with stress-related disorders experience as supportive for recovery. Methods: The systematic review was designed as a qualitative meta-synthesis following the recommendations
Historical archaeology in Scandinavia is an expand- ing field, but despite its global nature, the discipline is trapped in methodological nationalism. The early modern and modern societies are generally studied us- ing the current national borders even though the ma- terial culture should not be constrained in this way. By illustrating with both theoretical and empirical ex- amples, the objective
Surface water pollution consists of various pollutants like heavy metals (Cu, Cr, Pb, and Ni), metalloids (Se, As, and Ag), and organic pollutants (dyes, antibiotics, pharmaceuticals, pesticides, and phenolic compounds). The escalating issue of water pollution requires innovative solutions for mitigation and climate resilience. Although various advanced techniques are being developed for removing
The intervention Balancing Everyday Life™ (BEL) helps service users achieve a balance among everyday activities and enhance personal recovery. BEL builds upon research for people with mental illness and on evidence from earlier activity-based interventions. This methodological paper presents the theoretical basis for BEL, which rests on five pillars of theories and models. Further, the BEL topics
I denna rapport presenteras resultat och åtgärdsförslag som syftar till att ge rektorer goda förutsättningar att bedriva ett hållbart skolledarskap d.v.s. ett ledarskap som utgår från förskolans och skolans huvuduppgift (det vill säga barns och elevers lärande), har ett långt tidsperspektiv, sprids i organisationen, använder mänskliga och materiella resurser med eftertanke (inklusive rektors egen
Biocatalysis has emerged as a cornerstone of sustainable manufacturing, yet conventional modes are hindered by inherent limitations such as metabolic interference, mass transfer barriers, and instability. This study presented a novel platform using fragmented Gluconobacter oxydans, combining the autonomous cofactor regeneration of whole cells with the superior substrate accessibility of free enzym
Background: Obesity is a chronic disease linked to over 200 health conditions, reduced quality of life, and increased mortality. Despite the availability of multimodal treatments, there is a lack of standardised, patient-centred outcome measures to effectively assess and improve clinical care. This project aimed to define a core set of standardised outcome measures for adults with obesity, incorpo
The field of high energy physics (HEPs) has seen a marked increase in the use of machine learning (ML) techniques in recent years. The proliferation of applications has revolutionised many aspects of the data processing pipeline at collider experiments including the Large Hadron Collider (LHC). In this whitepaper, we discuss the increasingly crucial role that ML plays in real-time analysis (RTA) a
Background: Lignocellulosic waste is a desirable biomass for use in second generation biorefineries. Up to 40% of its sugar content consist of pentoses, which organisms either take up sequentially after glucose depletion, or not at all. A previously described Escherichia coli strain, PPA652ara, capable of simultaneous consumption of glucose, xylose and arabinose was in the present work utilized fo
Background: Many children who have overweight or obesity before puberty can develop obesity in early adulthood, which is associated with increased morbidity and mortality. The preschool years (ages 0-5) represents a point of opportunity for children to be active, develop healthy eating habits, and maintain healthy growth. Surveillance of childhood overweight and obesity in this age group can help
