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Background: Newborns, admitted to the Neonatal Intensive Care Unit (NICU), are exposed to a large number of medications, the majority of which are not labeled for use in infants, especially in preterm newborns, because clinical trials on their benefits and harms are lacking. There is a huge gap in knowledge on pharmacokinetic (PK) data in sick preterm infants, including that of drug penetration to

Hereditary deficiencies of protein S (PS) increase the risk of thrombosis. However, assessing the plasma levels of PS is complicated by its manifold physiological interactions, while the large inter-individual variability makes it problematic to establish reliable cut-off values. PS has multiple physiological functions, with only two appearing to have significant anticoagulant properties: the acti

Microbunching instability (MBI) has been one of the most challenging issues in designs of high-brightness beam transport lines for single-pass or recirculating accelerators. Although the intrabeam scattering (IBS) has long been studied in lepton or hadron storage rings as a slow diffusion process or in high-intensity proton linear accelerators as one mechanism for the beam halo, the effects of IBS

The modelling of biological systems often consists into differential equation models that need to be fitted to experimental data. During this complex process, the practical experience of the biologist and the theoretical abstraction of the modeller require back-and-forth refinements of the model, design of new experiments and inclusion of more data-points into the fitting procedure. Available opti

BACKGROUND: Central venous catheter (CVC) misplacement occurs frequently after right subclavian vein catheterization. It can be avoided by using ultrasound to confirm correct guidewire tip position in the lower superior vena cava prior to CVC insertion. However, retraction of the guidewire during the CVC insertion may dislocate the guidewire tip from its desired and confirmed position, thereby res

Community-based approaches are pursued in recognition of the need for place-based responses to environmental change that integrate local understandings of risk and vulnerability. Yet the potential for fair adaptation is intimately linked to how variations in perceptions of environmental change and risk are treated. There is, however, little empirical evidence of the extent and nature of variations

Precise monitoring of cyanobacteria concentration in water resources is a daunting task. The development of reliable tools to monitor this contamination is an important research topic in water resources management. Indirect methods such as chlorophyll-a determination, cell counting, and toxin measurement of the cyanobacteria are tedious, cumbersome, and often lead to inaccurate results. The quanti

Background: The quest for diagnostic tools for the detection of cutaneous malignant melanoma (cMM) is ongoing. A challenge in cMM care is not overlooking cMM at an early stage, while simultaneously avoiding unnecessary biopsies or excisions of benign pigmented skin lesions (PSLs). A novel hyperspectral imaging (HSI) device is shown to have potential for differentiating equivocal PSLs in Asian skin

High expression of Junctional Adhesion Molecule-A (JAM-A) has been linked with poor prognosis in several cancers, including breast cancers overexpressing the human epidermal growth factor receptor-2 (HER2). Furthermore, JAM-A expression has been linked with regulating that of HER2, and associated with the development of resistance to HER2-targeted therapies in breast cancer patients. The purpose o

OBJECTIVE:  To identify clinical, microscopic, and biochemical characteristics that differentiate cytolytic vaginosis (CV) from vulvovaginal candidiasis (VVC).METHODS:  The present cross-sectional study analyzed the vaginal contents of 24 non-pregnant women aged 18 to 42 years who were attended at the Genital Infections Clinic at Centro de Atenção Integral à Saúde da Mulher da Universidade Estadua

Kapitlet lyfter fram frågan om mänskliga rättigheter i utvalda former och hur de påverkar migranters positioner. Ett svenskt exempel illustrerar de utmaningar som migranter står inför i termer av exkludering.

We present a consistent set of calculated energies and E1, M1, E2, M2 radiative transition data for the main n = 3 levels from the 3s23p4, 3p6, 3s3p43d, 3s23p23d2, 3s3p5, 3s23p33d, and 3s3p33d2 configurations for S-like ions from Cr ix to Cu xiv. The fully relativistic multiconfiguration Dirac–Hartree–Fock method implemented in the GRASP2K code is used to perform the present calculations. The exci

The major softwood hemicellulose is galactoglucomannan (GGM), an abundant polysaccharide which constitutes up to 25% of the dry weight of wood, much of which is discarded in current refinery practices. Among the enzymes responsible for the degradation of this hemicellulose are the β-mannanases. Apart from their natural hydrolytic action, some β-mannanases have the ability to catalyse the synthesis

Glucagon is secreted from the pancreatic alpha cells and plays an important role in the maintenance of glucose homeostasis, by interacting with insulin. The plasma glucose levels determine whether glucagon secretion or insulin secretion is activated or inhibited. Despite its relevance, some aspects of glucagon secretion and kinetics remain unclear. To gain insight into this, we aimed to develop a

In the dawning age of autonomous driving, accurate and robust tracking of vehicles is a quintessential part. This is inextricably linked with the problem of Simultaneous Localisation and Mapping (SLAM), in which one tries to determine the position of a vehicle relative to its surroundings without prior knowledge of them. The more you know about the object you wish to track—through sensors or mecha