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The High Throughput Truthing project aims to develop a dataset for validating artificial intelligence and machine learning models (AI/ML) fit for regulatory purposes. The context of this AI/ML validation dataset is the reporting of stromal tumor-infiltrating lymphocytes (sTILs) density evaluations in hematoxylin and eosin-stained invasive breast cancer biopsy specimens. After completing the pilot

In recent years, researchers have extensively investigated hepatocellular carcinoma (HCC), a prevalent cancer type worldwide. Its resistance to conventional treatments highlights the promise of theragnostic nanoparticles, offering multiple tools within a single platform for fighting HCC cells. In this research, using polyaniline (PANI)-coated cobalt ferrite nanoparticles (CFO), an innovative nanoc

We report on an exact theory for ensembles of globally coupled, heterogeneous complex Riccati equations. A drastic dimensionality reduction to a few ordinary differential equations is achieved for Lorentzian heterogeneity. By applying this technique, we obtain low-dimensional firing-rate equations for populations of spiking neurons with a clustered substructure.

Background: Congenital heart disease (CHD) is the most common organ anomaly in humans affecting approximately 1:125 newborns worldwide. Early diagnosis enables postnatal stabilisation and may improve outcomes, especially in critical CHD, in which the circulation is dependent on patency of the arterial duct. Detection of CHD in newborns remains incomplete and current screening programs do not aim t

School-related functional impairment is common in children and adolescents with obsessive-compulsive disorder (OCD). However, little is known about the characteristics of youth with OCD who struggle in school, whether these struggles interfere with treatment outcomes, and whether treatment improves school-related function. Among 385 youth with OCD at a specialist clinic (mean age [sd] = 13.7 [2.5]

Recent studies have demonstrated that the transcription factor hepatocyte nuclear factor 4α (HNF4A) drives epithelial differentiation in the renal proximal tubules (PTs) and is critical for maintaining a mature PT phenotype. Furthermore, HNF4A down-regulation has been observed following kidney injury in mouse models. The aim of the present work was to investigate the role of HNF4A during acute and

Alla människor har rätt till hälsa enligt artikel 12 Konventionen om ekonomiska, sociala och kulturella rättigheter (ICESCR) och artikel 35 i EU:s rättighetsstadga (stadgan). För många människor är läkemedel livsviktiga. Emellertid har läkemedelsbolag med patenträttigheter en möjlighet till fri prissättning. Företag behöver tjäna pengar för att kunna forska fram nya produkter och läkemedelsbolag kAccess to pharmaceuticals can be vital for a lot of people. The public’s right to health is ensured by article 12 of the International Covenant on Economic, Social and Cultural Rights (ICESCR) and by article 35 of the Charter of Fundamental Rights of the European union (the EU Charter). However, pharmaceutical companies with patent rights can charge whatever price they want on medicines. Companies

Klimatförändringarna och följderna av dessa har upprepade gånger utpekats som en av vår tids ödesfrågor. Fokus har fram tills relativt nyligen till övervägande del legat på hur klimatförändringar kan förhindras genom utsläppsbegränsningar och omställning till ett mer hållbart samhälle. I och med att kunskaperna ökat synes det dock idag stå klart att flertalet av klimatförändringarnas effekter redaClimate change and its consequences have long been viewed as one of the defining challenges of our time. The focus of research pertaining to climate change have until recently been overwhelmingly focused on the issue of mitigation while adaptation to climate change has received comparatively little attention. But, as the realization has dawned that many consequences of climate change are already b

För och nackdelar med ett human traffickingnarrativ Human trafficking har, under 2000-talet, erhållit mycket uppmärksamhet, något som har resulterat i uppkomsten av ett dominerande internationellt traffickingnarrativ. Syftet med denna uppsats är att undersöka och problematisera Europarådets Group of experts on action against trafficking in human beings (GRETA:s) narrativ om barntrafficking. MotiThe pros and cons of a human trafficking narrative. Human trafficking has, in the 21st century, received substantial attention, which has resulted in the manifestation of a dominant international trafficking narrative. The pur-pose of this essay is to examine and problematize the European Councils Group of ex-perts on action against trafficking in human beings (GRETA:s) narrative regarding child

Dagens arbetsmarknad har blivit allt mer rörlig och individer har fler möjligheter gällande valet av arbetsplats än vad de under tidigare decennier haft. Humankapitalet har även kommit att ses som en allt mer betydande faktor för organisationers konkurrenskraft. Dessa aspekter har i sin tur lett fram till att en organisations arbete med employer branding kommit att spela en allt mer väsentlig roll

The occurrence of climate change will have a significant impact on society and adapting to a more sustainable environment is of key importance. The dangers of climate change will include temperature and precipitation patterns becoming more extreme creating a substantial impact on society. Greece’s location and climate make it particularly vulnerable to a changing climate and climate impact assessm

A series of tests were performed to explore the limits of two capacitive level sensors using the principle of parallel finger layout (sometimes called comb fingers) for sensing. The goal was to present a decision basis for Baxter to use when choosing a sensor to implement in their next generation hemodialysis machine. The devices under tests were 1) sensor type A: developed in-house and 2) sensor

The municipality of Helsingborg, located in Scania implemented the Livskvalitetsprogrammet (The programme of living quality) in 2016. The goal with the programme is to unite sustainable development and quality of life. The work with the programme will continue towards 2024. I was given the assignment to research the knowledge of the programme throughout the organisation. The questionnaire is to be

Mountains provide a variety of ecosystem services, such as drinking water, which sustains not only mountain communities but also people living further downstream. While climate change threatens most ecosystems, its negative impacts are up to three times greater in high altitudes. As well as changing the water cycle this further accelerates climate change. Although they contribute comparably little

This study aims to examine how the sensitivity for macroeconomic announcements surprises changes for the exchange rate in terms of a crisis. Previous research has been biased for U.S announcements and their relation towards emerging market, which has shown that U.S announcements affect more than the domestic. It also suggests that business cycle and uncertainty affect and increase the reaction for

Medborgarnas politiska delaktighet har en central roll i en god demokrati. För att uppnå politiskt deltagande, främst bland de grupper i samhället som sällan deltar, använder många svenska kommuner sig idag av medborgardialog. Medborgardialog innebär att politiker och tjänstemän bjuder in till samtal för att diskutera olika frågor som berör medborgarnas intressen. Denna uppsats är en normativ stud

Statsansvaret för folkmord har en jus cogens status i internationell sedvanerätt och utgår från den generella hänförbarhetsregeln: huruvida de inom staten aktiva personer eller grupper är verksamma, eller åtminstone kan anses vara verksamma å statens vägnar är avgörande för att staten kan hållas ansvarig. För att icke-statliga aktörer kan vara hänförliga till staten måste förhållandet dem emellan State responsibility for commission of genocide has a jus cogens status in customary international law and is based on the general rule of attribution: whether the persons or groups acting within the State are acting, or at least can be treated as acting on behalf of the State is key for State responsibility to arise. For non-state actors to be attributable to the State the relationship between th

Uppsatsens syfte är att undersöka huruvida kulturegendom tillmäts ’tillräckligt skydd’ av internationell rätt i väpnade konflikter, med betoning på den juridiska grunden för att åtala förstörelse av kulturarv som ett krigsbrott under internationell straffrätt. Jag undersöker hur de mest relevanta traktaterna i internationell rätt har uppstått sedan antagandet år 1954 av Haagkonventionen för skyddThe purpose of this thesis is to examine whether cultural property is attributed ‘sufficient protection’ by international law in armed conflicts, with an emphasis on the legal basis for prosecuting its destruction as a war crime under international criminal law. I research how the most relevant treaties in international law have emerged since the adoption of the Convention for the Protection of Cu

Denna uppsats ämnar kritiskt granska utrikesförvaltningens handlingsplan för feministisk utrikespolitik utifrån ett rättighetsperspektiv. Syftet med uppsatsen är att bidra till en förståelse för huruvida den feministiska utrikespolitiken verkar för att säkerhetsställa flickors och kvinnors möjligheter och makt att påverka sina liv och samhällen, men också hur politiken verkar för en lokal, regiona