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Engineering design, in concise terms, is what engineers do using what they know. It is the underlying decision making activity that determines what is to be built and how it should be built. An ever present requirement in engineering design is that the structure should be safe. While historical approaches to safety in design relied on experience and engineering judgment, modern approaches have rat

Antibody radionuclide conjugates are an emerging modality for targeted imaging and potent therapy of disseminated disease. Coupling of radionuclides to monoclonal antibodies (mAbs) is typically achieved by applying non-site-specific labelling techniques. With the ambition of reducing variability, increasing labelling efficacy and stability, several site-specific conjugation strategies have been de

To develop sustainable supply chains in a way that their negative environmental and social effects are minimized, shortand long-term targets should be set. The transformation of supply chains towards these targets calls for the development of innovative strategies and the need to continuously identify, classify, and tackle the challenges that can hinder the execution of such strategies. To develop

Increasing soft error rates in recent semiconductor technologies enforce the usage of fault tolerance. While fault tolerance enables correct operation in the presence of soft errors, it usually introduces a time overhead. The time overhead is particularly important for a group of computer systems referred to as real-time systems (RTSs) where correct operation is defined as producing the correct re

Research facilities such as spallation sources and synchrotrons generate radiation for use in atomic-level or molecular-scale experiments. These facilities can be viewed as complex safety-critical systems. An important aspect of the safety management of such systems is the short safety education and training programme the users are required to undergo in order to gain facility access. As research

Sleep problems and short sleep duration have been linked to adverse health effects, such as cardiovascular disease and diabetes, but the mechanisms are not fully understood. Finding biomarkers could explain mechanistic pathways and help in understanding relationships between sleep and cardiometabolic health. The aim was to assess if sleep duration and sleep quality affect the cardiometabolic-relat

Background and study aims Surgical resection is standard treatment of T2 rectal cancer due to risk of concomitant lymph node metastases (LNM). Local resection could potentially be an alternative to surgical treatment in a subgroup of patients with low risk of LNM. The aim of this study was to identify clinical and histopathological risk factors of LNM in T2 rectal cancer. Patients and methods This

Professor emeritus Kontaktinformation E-post: anders [dot] ljungar-chapelon [at] mhm [dot] lu [dot] se Telefon: +46 40 32 54 33Organisation Lärare (Musikhögskolan) WebbplatsAnders Ljungar-Chapelons profil i Lunds universitets forskningsportalEmeritus Prof. Dr. in flute and researchAnders Ljungar-Chapelon is an emeritus professor of flute and a researcher (artistic research and music education) at

https://www.mhm.lu.se/anders-ljungar-chapelon - 2026-07-03

https://www.medarbetarwebben.lu.se/evenemang/supporting-research-practice-workflows-challenges-and-needs-cloned - 2026-07-04

Pigment epithelium derived factor (PEDF), a ubiquitously expressed 50 kDa secreted glycoprotein, was recently discovered to regulate self-renewal of neural stem cells and have a supportive effect on human embryonic stem cell growth. Here, we analyzed expression of PEDF in the murine hematopoietic stem cell (HSC) compartments and found that PEDF is highly expressed in primary long-term HSCs. Theref

Voltage-gated Ca2+ (CaV) channels trigger glucose-induced insulin secretion in pancreatic beta-cell and their dysfunction increases diabetes risk. These heteromeric complexes include the main subunit alpha1, and the accessory ones, including subunit gamma that remains unexplored. Here, we demonstrate that CaV gamma subunit 4 (CaVγ4) is downregulated in islets from human donors with diabetes, diabe

Energy poverty has been kept at bay in Sweden for the past decades owing to several beneficial circumstances. However, geopolitical pressure and an accelerating energy transition are changing the circumstances and exposing vulnerabilities to energy poverty in Sweden particularly connected to electricity price peaks. The circumstantial nature of the exposed risks for energy poverty motivates a conc

Aims: Transforming growth factor-beta (TGF-β) exists in three isoforms TGF-β1, -β2, and -β3. TGF-β1 has been suggested to be important for maintaining plaque stability, yet the role of TGF-β2 and -β3 in atherosclerosis remains to be investigated. This study explores the association of the three isoforms of TGF-β with plaque stability in the human atherosclerotic disease. Methods and results: TGF-β