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G protein-coupled receptor 30 (GPR30) is a ubiquitously expressed receptor reported to bind and become activated by estrogen (17β-estradiol). However, the role of GPR30 as an estrogen receptor for rapid estrogenic signaling is not completely accepted, and controversies exist regarding the identity of the cognate ligand, signaling, and subcellular localization of the receptor. Expression of GPR30 i
In this thesis the heating area of a belt furnace for annealing metal powder has been modeled. The model was extended with PI-controllers for controlling the energy added to the model. It was simulated with differently tuned controllers to test tuning principles for finding suitable control parameters for the process. The most promising tuning principles was then written as a manual with the aim f
Since the introduction of Edison’s lightbulb over one-hundred years ago, humanity has struggled to keep up with electrification for all. With global attention now aimed at sustainable energy production, the struggle becomes more complex by not only obliging energy access, but access to clean energy. The concept of microgrids has been promising for filling in the demand, but not quickly enough to m
Neonicotinoid insecticides are agonists to nicotinic acetylcholine receptors (nAChRs) in the brains of insects. At sub-lethal doses these chemicals cause behavioral abnormalities in several bee species, reducing overall fitness. nAChRs expressed in the optic lobes of insects bind neonicotinoids, thus may be involved in these behavioral changes. Here we attempted without success to visualize the pr
OBJECTIVE: Avacopan (AVAC), an oral selective C5a receptor inhibitor, has been approved for treatment in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Outside randomized controlled studies, real-world data are scarce. The aim of this study was to provide further insight into the clinical experience of AVAC.METHOD: We analysed data from 16 patients with severe AAV include
Accurate mapping of earthquake-damaged buildings is essential for rapid post-disaster assessment and urban recovery planning. Very high-resolution (VHR) satellite imagery enables large-scale geospatial damage detection; however, conventional convolutional neural networks (CNNs) often struggle to model complex spatial dependencies and nonlinear damage patterns efficiently. To address these limitati
Increased adoption of PV systems can help to mitigate climate change as it increases the use of renewable energy instead of fossil fuels and thus decreases greenhouse gas emissions.
This article is about finding the limit set for banded Toeplitz matrices. Our main result is a new approach to approximate the limit set Λ(b), where b is the symbol of the banded Toeplitz matrix. The new approach is geometrical and based on the formula Λ(b) = ∩ρ∊(0, ∞) sp T (bρ), where ρ is a scaling factor, i.e., bρ(t):= b(ρt), and sp(∙) denotes the spectrum. We show that the full intersection ca
Despite the widely recognized potential of product-as-a-service (PaaS) business models to contribute to the circular economy, many industrial case studies have reported that several systemic factors tend to hinder product manufacturers from effectively designing such solutions. More specifically, factors such as linear value chains, organizational structures, and market and financial conditions te
Rocky planets may acquire a primordial atmosphere by the outgassing of volatiles from their magma ocean. The distribution of O between H2O, CO, and CO2 in chemical equilibrium subsequently changes significantly with decreasing temperature. We consider here two chemical models: one where CH4 and NH3 are assumed to be irrevocably destroyed by photolysis and second where these molecules persist. In t
The impacts of climate change may be particularly severe for geographically isolated populations, which must adjust through plastic responses or evolve. Here, we study an endangered Arctic plant, Primula nutans ssp. finmarchica, confined to Fennoscandian seashores and showing indications of maladaptation to warming climate. We evaluate the potential of these populations to evolve to facilitate sur
IntroductionResearch evidence suggests that radiographers often rely on previous training, traditional practices, work experience and protocols developed within the department rather than up-to-date research-based evidence in their daily practice. The aim of the study was to investigate factors that might impact the development of evidence-based practice amongst radiographers in clinical public se
Cytidine triphosphate synthetase (CTPS) is a key enzyme in nucleic acid and phospholipid biosynthesis and its activity is increased in certain human cancers, making it a promising drug target. The crystal structure of the synthetase domain of human CTPS, which represents the first structure of a CTPS from an eukaryote, has been determined. The structure is homotetrameric and each active site is fo
Diet has a pivotal role in shaping the composition, function and diversity of the gut microbiome, with various diets having a profound impact on the stability, functionality and diversity of the microbial community within our gut. Understanding the profound impact of varied diets on the microbiome is crucial, as it will enable us not only to make well-informed dietary decisions for better metaboli
To address environmental and climate issues, alternative technologies to fossil resources are sought after, both for the production of fuels and of chemicals. Algae appear as an attractive solution and have applications in the food, feed, energy or chemistry at large. A study funded by ADEME and conducted by ENEA, a consulting firm for energy and sustainable development for the industrial sector,
The technique to perform adnexectomy for adnexal masses has shifted over the last decades, from open surgery towards minimally invasive approaches. At the same time caution is warranted to prevent perioperative intra-abdominal spilling of cyst content which can be a challenge especially for very large masses. vNOTES (vaginal Natural Orifice Transluminal Endoscopic Surgery) combines a vaginal appro
Residents of the Sahel depend on livestock, but harsh environmental conditions during the dry season limit rangeland forage, which is the main source of livestock feed. Al-though operational tools exist for assessing and monitoring forage quantity during the dry season, assessments of forage quality are lacking. We addressed this gap by developing satellite-based monitoring of forage quality acros
