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Since their discovery more than 70 years ago antibiotic drugs have been efficient tools for treating bacterial infections, and their use has reduced the number of fatalities and the suffering from bacterial diseases. However, the use of antibiotics may lead to resistance to the same or other antibiotics. The risk of resistance appears to be larger in veterinary medicine, since antibiotics have bee
Chromosomal instability is a known hallmark of many cancers. DNA polymerases represent a group of enzymes that are involved in the mechanism of chromosomal instability as they have a central function in DNA metabolism. We hypothesized that genetic variation in the polymerase genes may affect gene expression or protein configuration and by that cancer risk and clinical outcome. We selected four gen
Human trafficking is the world’s third largest organized crime after the illegal trade in arms and drugs. It is a growing problem in our increasingly globalized world and people are daily transported between countries to be exploited for different purposes. Not even Sweden is spared from this cynical business, although we may not hear much about it. The aim of this study was to investigate how Swe
With a worldwide increase in climate-related disasters and the global temperature on the rise, the effects of climate change are already being felt. Among those most at risk are the poor in developing countries, often living in informal settlements or „slums‟. In order to reduce associated risks and strengthen people‟s own coping capacities, there is an urgent need for knowledge about the factors
Freshwater of good quality is important, even necessary, for human society as well as natural ecosystems to function. However, the uneven distribution of freshwater globally together with other problems such as over-population and pollution all contribute to water stress and water scarcity in many countries. These issues are getting worse and worse. A growing number of companies and organizations
This thesis examines and analyses the relationship between the principle of complementarity and the principle of universal jurisdiction. The establishment of the International Criminal Court provides for the first time in history a permanent international criminal institution. One of the most important principles on which the ICC is built upon is the principle of complementarity. The road towards
The international character that surrounds the shipping industry has traditionally meant that rules regarding the public law of the sea or the private maritime law are internationally regulated through regulations, state practice, international conventions or international customary law. Since the 1970s, there has been an increasing concern for both the marine environment and the safety onboard sh
In this study, we first determined the low molecular weight dissolved organic carbon (LMW DOC) concentration-dependent kinetics of soil respiration in a temperate grassland soil sampled on successive occasions. We then used the established relationship to estimate in situ LMW DOC concentrations from basal respiration measurements. C-14-labelled glucose was used as a model substrate and was added t
The purpose of the present study was to investigate the amplifying function of the nucleus accumbens septi region (NAS) in 6-hydroxydopamine (6-OHDA)-induced rotational behaviour by implanting fetal dopamine (DA)-rich mesencephalic cell suspensions unilaterally in the NAS of rats previously subjected to combined mesostriatal (MS) and NAS 6-OHDA lesions. First, all the rats received a unilateral 6-
Recent work has uncovered a role of the microRNA (miRNA) miR-29 in remodeling of the extracellular matrix. Partial bladder outlet obstruction is a prevalent condition in older men with prostate enlargement that leads to matrix synthesis in the lower urinary tract and increases bladder stiffness. Here we tested the hypothesis that miR-29 is repressed in the bladder in outlet obstruction and that th
BACKGROUND: Arsenic in drinking water causes severe health effects. Indigenous people in the South American Andes have likely lived with arsenic-contaminated drinking water for thousands of years. Inhabitants of San Antonio de los Cobres (SAC) in the Argentinean highlands generally carry an AS3MT (the major arsenic-metabolizing gene) haplotype associated with reduced health risks due to rapid arse
In this paper, we show how studies of fracture mineral paragenesis, their orientation and Ar-40/Ar-39 geochronology can be applied in order to recognise the brittle tectonothermal evolution in an area. Samples were selected from nearly 18 km of drill cores from the upper I km of the Fennoscandian Shield obtained during the site investigation for a repository of spent nuclear fuel in Forsmark, cent
Disperse dyes are common sensitizers among textile dyes. Contact allergy to disperse dyes has been documented in studies carried out in southern Europe, however, corresponding studies have not been performed in the Scandinavian countries. The aim of this study was thus to evaluate the prevalence of allergic reactions to a mix of textile dyes consisting of 8 disperse dyes: Disperse (D) Blue 35, 10
Popular Abstract in Swedish Under de senaste årtiondena har prestandan i elektriska kretsar växt i en rasande takt. Detta har lett till otaliga innovationer som har förbättrat samhället. Grunden till denna utveckling grundar sig i två uppfinningar: transistorn och den integrerade kresten. Till skillnad från många andra grundläggande elektroniska komponenter har en transistor tre elektroder. En eRecent decades have seen an exponential increase in the functionality of electronic circuits, allowing for continuous innovation, which benefits society. This increase in functionality has been facilitated by scaling down the dimensions of the most important electronic component in modern electronics: the Si-based MOSFET. By reducing the size of the device, more transistors per chip area is possib
The mycoprotein was obtained from the company, Mycorena. The mycoprotein is a potential source of alternative protein of the animal origin used as the functional ingredients in the food industry. In this project, mycoprotein concentrate (MC) and mycoprotein isolate (MI) were produced by freeze-drying the biomass and pH-shift processing together with freeze-drying, respectively. Moreover, the funct
Purpose – The purpose of this master thesis is to test the applicability of the dashboard development procedure by Vilarinho, Lopes and Sousa (2017) in the application case of a single case study for a redesign of a production dashboard. In doing so a practical new dashboard layout shall be reached, which considers the needs of all dashboard users. Design/methodology/approach – This thesis was co
De flesta av oss associerar nog kemikalier med något negativt, men sanningen är att kemikalier utgör en förutsättning för mycket av den välfärd som vi ser idag. Tvärtemot vad man kan tro, så är det inte bara i produkter som plast, färg, lösningsmedel, med mera som dessa förekommer, utan även i produkter som räddar liv, till exempel i utrustning inom sjukvården och för vattenrening. Därför är de meThe production and use of chemicals has grown exponentially over the past 50 years. Although the knowledge of hazards and risks associated with chemicals towards humans and the environment has increased, we know frightenedly little about how dangerous these might become when part of finished products. Companies now need to be more concerned about which chemicals exist in their products. For the co
Skatterätten anknyter till många civilrättsliga termer och bestämmelser. Vid beskattningen har de getts samma innebörd inom skatterätten som i civilrätten. Till följd av den vida avtalsfriheten har det gett de skatteskyldiga stora möjligheter att påverka beskattningen. Förehavanden kan således konstrueras så att de träffas av skattesystemets lägre skattesatser. Häremot har såväl rättstillämparen sThe Swedish tax system is linked to many civil law concepts and provisions. In taxation, they have been given the same meaning in tax law as in civil law. As a result of the wide freedom of contract, this has given taxpayers great opportunities to influence taxation. Dealings can thus be designed so that they are affected by the tax system's lower tax rates. On the other hand, both the judicia
Immunotherapy utilizes the patient’s own immune system for the treatment of cancer. Due to exceptional antigen-presentation capacity Dendritic Cells (DCs) have great potential for cancer immunotherapy. Using direct cellular reprogramming our group has identified a combination of transcription factors, PU.1, IRF8, and BATF3 that reprograms mouse and human fibroblasts and a range of cancer cell line
Study purpose: The maritime shipping industry, particularly the commercial sector, is a significant contributor to carbon emissions and environmental pollution. Various solutions are being proposed to enhance the sector's sustainability, including the adoption of wind propulsion technologies. However, the economic feasibility of these technologies on a large scale remains uncertain. Despite th
