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Popular Abstract in Swedish Blodkärlens glatta muskulatur kan anpassa sig till ett ökat tryck genom omstrukturering och hypertrofi, vilket ofta ses hos patienter med hypertoni. De molekylära mekanismerna som ger upphov till dessa effekter är inte fullständigt klarlagda. Vi har därför utvecklat en modell för att undersöka effekterna av tryck (sträckning av kärlväggen) på kärlpreparat från portaven Vascular smooth muscle can adapt to increased intraluminal pressure by remodelling and hypertrophy, as seen in hypertension. The molecular mechanisms responsible for this are still incompletely characterized. We have developed an organ culture system where strips of rat or mouse portal veins are cultured for 1 to 3 days loaded (stretched) by an attached weight and then studied for morphology, func

Popular Abstract in Swedish Populärvetenskaplig sammanfattning på svenska Denna avhandling handlar om kalretikulin (engelska: calreticulin; CRT), ett protein som bidrar till att andra protein får rätt struktur och som också är inblandat i en kvalitetskontroll av dessa. CRT ser också till att kalciumbalansen i cellen upprätthålls. Hur går detta då till och hur bidrar denna avhandling till att öka kCalreticulin (CRT) is an endoplasmic reticulum (ER)-located protein involved in quality control of newly synthesized proteins as well as in calcium homeostasis of the cell. Most of what is known about CRT arises from studies of mammalian systems. However, using a Arabidopsis thaliana CRT gene expressed in mouse fibroblasts deficient of endogenous CRT, the wild type phenotype could be rescued with

Vocal learning is a critical behavioral substrate for spoken human language. It is a rare trait found in three distantly related groups of birds-songbirds, hummingbirds, and parrots. These avian groups have remarkably similar systems of cerebral vocal nuclei for the control of learned vocalizations that are not found in their more closely related vocal non-learning relatives. These findings led to

Popular Abstract in Swedish Solljusets effekter på abiotiska och bakteriella kolflöden i akvatiska system I denna avhandling behandlar jag solljusets effekter på organiskt material. Jag har analyserat hur solljus förändrar olika sorters löst organiskt kol och partikulärt organiskt kol. Vidare har jag utvärderat de indirekta effekterna som förändringar av löst organiskt kol har på bakterier. SlutlIn this Thesis, I studied some of the current aspects of organic matter photochemistry. I analyzed abiotic phototransformations of several types of dissolved (DOM) and particulate organic matter (POM). I also evaluated the effects of phototransformation of several types of DOM on bacteria. Finally, in a field experiment, I analyzed net effects of solar radiation on organic matter decomposition. DO

In many species, population sex ratios have far-reaching consequences for a wide variety of population-level and behavioural processes and can directly influence sexual selection through differential effects on male and female mating behaviour. Although sex ratios are often treated as more or less stable population characteristics, recent theoretical evidence suggests that sex ratios fluctuate und

The rat stomach is rich in endocrine cells. The acid-producing (oxyntic) mucosa contains ECL cells, A-like cells, and somatostatin (D) cells, and the antrum harbours gastrin (G) cells, enterochromaffin (EC) cells and D cells. Although chromogranin A (CgA) occurs in all these cells, its processing appears to differ from one cell type to another. Eleven antisera generated to different regions of rat

Intestinal alkaline sphingomyelinase (alk-SMase) digests sphingomyelin and the process may influence colonic tumorigenesis and cholesterol absorption. We recently identified the gene of human alk-SMase and cloned the cDNA. Cross-species screening of homology in GenBank found a hypothetical rat protein, XP_221184, with 491 amino acid residues, which shares 73% identity with human alk-SMase. Based o

Fifteen years after the heavy storm "Vivian", it is still not clear how succession in subalpine forests that were affected by the storm will continue and when regrowing forests will provide effective protection from natural hazards such as avalanches. We used a simulation model to evaluate forest succession, forest structure and the protective effect in subalpine blowdown areas after 50 simulation

Popular Abstract in Swedish Avhandlingens syfte är att analysera relationen och interaktionen mellan genus och nation i en svensk kontext under 1900-talets första hälft. När kvinnor mobiliseras nationellt inom olika typer av nationalism är det oftast moderskapet som åberopas. Detta är en av utgångspunkterna i avhandlingen. Föreställningar om ett nationellt moderskap återfinns också i flera olika sThe aim of this thesis is to analyse the relationship and interaction between gender and nation in a Swedish context, during the first half of the twentieth century. When women become mobilised on a nationwide basis within different types of nationalism, it is often motherhood that is invoked. This is just one point of departure in my dissertation. Perceptions of a national motherhood are also fou

Purpose: Prostaglandin E-2 and its EP1 receptor were suggested as endogenous modulators of bladder function in the normal physiological state and under pathophysiological conditions. We investigated if the new EP1 receptor antagonist PF-2907617-02 would influence the regulation of normal micturition in rats, and if it affects bladder function in animals with partial bladder outlet obstruction. Mat

Energy consumption is today an important design issue for all kinds of digital systems, and essential for the battery operated ones. An important fraction of this energy is dissipated on the processors running the application software. To reduce this energy consumption, one may, for instance, lower the processor clock frequency and supply voltage. This, however, might lead to a performance degrada

Background. Umbilical artery Doppler velocimetry is a routine method for fetal surveillance in high-risk pregnancy. Uterine artery Doppler seems to give comparable information, but it can be difficult to interpret as there are two arteries, which might show notching and/or increased pulsatility index (PI) as signs of increased vascular impedance. Combining the information on vascular resistance on

BACKGROUND: The atherothrombotic risk pattern of the nephrotic syndrome resembles that of hyperhomocysteinemia. However, the effect of nephrotic range proteinuria on homocysteine metabolism has never been studied. METHODS: The study included 11 male nephrotic patients with idiopathic membranous nephropathy who underwent a treatment trial with adrenocorticotrophic hormone and 11 male non-nephrotic,

Objectives: Tumor-associated-trypsin inhibitor (TATI) is frequently coexpressed with trypsinogen in tumors. Recently, we found expression of trypsinogens in prostate cancer. We have now studied whether TATI is also expressed in prostate cancer and if TATI expression is associated with Gleason grade, proliferation, and neuroendocrine differentiation. Methods: Expression of TATI and prostate-specifi

A novel design of a biochemical oxygen demand (BOD) biosensor has been developed for on-line monitoring of easily biodegradable organic compounds in aqueous samples. The biological recognition element of the sensor could be easily renewed by injecting new bacterial paste without disassembling the sensor system. The sensor measurements were carried out in the initial-rate mode using a flow injectio

The aim of the present study was to compare cellular and noncellular components of bronchoalveolar lavage fluid (BAL) in a group of children with a diagnosis of chronic diffuse parenchymal lung disease (cDPLD) and a group of children without parenchymal lung disease undergoing BAL for various clinical indications (control group). We evaluated cellular and non-cellular components (total proteins, a

Throughout the world, tidal marshes are being restored to obtain natural protection against recurring storm surges and sea level rise and to preserve the resources these habitats provide. Managed realignment, or breaching of the seaward dikes, is a restoration technique increasingly used; yet unsuitable site elevation has been a major constraint to habitat development. Controlled reduced tide (CRT

An integrated stratigraphic, paleoecological, and geochronological study of lake and fen sediments just beyond the terminus of Berendon Glacier provides insights into late Holocene climate, vegetation, and glacier change in the northern Coast Mountains of British Columbia. Cores collected from two small lakes in the foreland of Berendon Glacier and pits dug in a nearby fen record Little lee Age an

Caveolae, plasma membrane invaginations particularly abundant in adipocytes, have been suggested to be important in organizing insulin signalling. Insulin-induced activation of the membrane bound cAMP degrading enzyme, phosphodiesterase 3B (PDE3B) is a key step in insulin-mediated inhibition of lipolysis and is also involved in the regulation of insulin-mediated glucose uptake and lipogenesis in a

In this paper we investigate the impact of nitrate (NO3-) concentration and temperature on the production of carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O). We studied sediment collected during spring, summer and autumn from a constructed pond in South Sweden. Homogenised sediment samples were dark incubated in vitro under N-2 atmosphere at 13 degrees C and 20 degrees C after addition