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Objectives: SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss-of-function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes. Here we describe a novel dominant variant in SLC4A4 in patients wit
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a multifactorial disorder involving gut-brain axis dysregulation, altered barrier integrity, microbial imbalance, and stress-related mechanisms, with limited nutritional strategies targeting these pathways. Tannin-rich extracts may exert barrier-protective, microbiota-modulating, and stress-related effects. In a prospective before-after pilo
Episodic memories are leveraged to predict upcoming input. Latent Cause Theory (Gershman et al., 2017) predicts that after moderate prediction errors, existing memories will be updated by integrating new information, while after large prediction errors, a new latent cause is inferred, and the unpredicted event is encoded as a separate trace. To date, no study has directly compared memory updating
Serglycin (SRGN) has been found overexpressed and secreted in glioblastoma (GBM), associated with tumorigenic signaling and poor prognosis. In this study, we aimed to elucidate the involvement of SRGN in the unfolded protein response (UPR), an oncogenic signaling pathway implicated in protein recycling and cell fate. Herein, we developed stably transduced LN-18shSCR GBM cells, expressing high leve
Hereditary spinocerebellar degenerations (SCDs) is an umbrella term that covers a group of monogenic conditions that share common pathogenic mechanisms and include hereditary spastic paraplegia (HSP), cerebellar ataxia, and spinocerebellar ataxia. They are often complicated with axonal neuropathy and/or intellectual impairment and overlap with many neurological conditions, including neurodevelopme
The main purpose with this Master's thesis has been to through a case study investigate and analyze the music library activity at the Public Library in Lund, in order to find out according to which ideas and principals this activity is run by. It also discusses how you at the music department handle your task as intermediary of music and how well this coincides with the users expectations. To
Abuse of alcohol is one of the biggest problems that society faces today. There are between three and four hundred thousand abusers in Sweden. In addition there are about three hundred thousand over consumers. The government bill proposed in 1977 gave the labour market most of the responsibility to solve the problem. They thought a meaningful job and a spirit of community were the most important f
The common way in which algal virus-host systems are discovered is when an algal culture collapses due to the virus-induced lysis. Therefore, the presence of a viral infection in a seemingly healthy culture of Chlamydomonas sp. is an oddity. This study describes such an infection in an algal sample from Örsjön, a lake in southern Sweden, sustained in culture for over six years with no observed adv
Authors: Marielle Johansson & Viktoria Kronborg Title: Gendersystem in LVU judgements. A qualitative study of gender differences in LVU judgements. [Translated title]. Supervisor: Mikael Sandgren When in trial everyone is supposed to be equal to the law. The aim of this study was from a gender perspective to explore how the childs legal guardian was described in judgments of 1 and 2§§ LVU.
Many of our cities have problems with air pollution and it have been shown to cause a lot of damage to human health. There are different kinds of air pollution, some are gaseous air pollutions like NOx or ground-level ozone and other air pollutions are particles. NOx forms in high temperatures from combustion processes like in a car motor. Ground-level ozone form in combination with NOx, hydrocarb
Syftet med denna studie är att undersöka om körsång kan användas som ett verktyg för att motverka psykisk ohälsa bland ungdomar genom elevhälsan. Vidare undersöktes även huruvida körpedagoger ser fördelar med att beakta körsångens hälsoeffekter i sin egen undervisning, och hur möjligheten för att använda körsång inom elevhälsan i dagens gymnasieskola ser ut. För att genomföra studien gjordes tre kThe purpose of this study is to investigate if choir singing can be used as a tool to prohibit mental illness or bad mental health amongst youths through student health services. The study also investigates if choir teachers can see benefits of teaching choir with choir singings health effects in mind, and what the possibility is to use choir singing as a tool in today’s high schools (Swedish gymn
The building industry is continuously adapting to the changing needs and demands. The rise in emissions, depletion of resources and accumulating waste are some of the important problems that have to be addressed by architects all over the world today. In this context, the thesis addresses these problems through informed building material choices and exploring the potential of circular use of resou
The digital age we live in is in constant development and the public libraries have had to adjust to this change partly by providing ebooks, digital audio books and web pages with information for their users. Digital books keep gaining popularity among Swedish citizens. The Swedish Library Act states that in terms of language the public libraries shall pay extra attention to the five national mino
Bakgrund: Psykisk ohälsa är ett växande hälsoproblem. Kreativa aktiviteter, som körsång, har visats ge personer en rad sociala, psykologiska och hälsofrämjande fördelar. Det finns forskning från andra professioner men det saknas ett arbetsterapeutiskt perspektiv. Att göra en litteraturöversikt är aktuellt för att konstatera vad det finns för forskning idag om sång i grupp och dess inverkan på persBackground: Mental illness is a growing health problem. Creative activities, such as choir singing, have proved to give people a range of social, psychological and health-promoting benefits. There are literature reviews from other professions but there is a void in knowledge when it comes to occupational therapy perspective and occupational science. A qualitative literature review is relevant to e
High humidity, high ash content and low heating values are the major disadvantages of using lignite without ant pretreatment. High moisture content and low energy density make some of the biomass resources disadvantages in direct energy production. In this thesis, the main aims to reduce the disadvantages of both sources and obtain fuel with different structural/physical properties by hydrothermal
Background: To investigate a patient-level single imputation approach for patient reported outcomes (PROs) that express similar contents or associated PROs, where a PRO whose value is missing at a particular timepoint is substituted by another PRO whose value is available at the same timepoint. Methods: We performed a simulation study on registry-based spondyloarthritis data to explore the potenti
1. The European Water Framework Directive requires the determination of ecological status in European fresh and saline waters. This is to be through the establishment of a typology of surface water bodies, the determination of reference (high status) conditions in each element (ecotype) of the typology and of lower grades of status (good, moderate, poor and bad) for each ecotype. It then requires
We developed a simple model to calculate the regional deposited dose of submicron aerosol particles in the respiratory system. This model incorporates measured outdoor and modeled indoor particle number size distributions, detailed activity patterns of three age groups (teens, adults, and the elderly), semi-empirical estimation of the regional deposition fraction, hygroscopic properties of urban a
This work describes and characterizes an algorithm for the nonambiguous reduction of multiexponentially decaying luminescence signals to scalar values of corresponding calibration temperatures. Previous evaluation schemes in phosphor thermometry make use of an intermediate step, where data reduction is achieved by fitting a model equation to phosphorescence decays in order to translate one or more
The causative microorganisms dictate the type of MDSC generated in sepsis patients, and a large proportion of PMN-MDSCs in gram-positive sepsis includes immunosuppressive myeloid blasts. MDSCs constitute a heterogeneous population of immature myeloid cells that potently suppress immune responses. They were identified originally in cancer patients and have since been reported to occur also in chron
