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Purpose: Previously identified transcriptomic signatures have been based on primary and metastatic melanomas with relatively few American Joint Committee on Cancer (AJCC) stage I tumors, given difficulties in sampling small tumors. The advent of adjuvant therapies has highlighted the need for better prognostic and predictive biomarkers, especially for AJCC stage I and stage II disease. Experimenta
A large proportion of cells that proliferate in the adult dentate gyrus under normal conditions or in response to brain insults exhibit only short-term survival. Here, we sought to determine which cell death pathways are involved in the degeneration of newly formed neurons in the rat dentate gyrus following 2 h of electrically induced status epilepticus. We investigated the role of three families
Introduction: In 2011, a homozygous mutation in GOSR2 (c.430G > T; p. Gly144Trp) was reported as a novel cause of Progressive Myoclonus Epilepsy (PME) with early-onset ataxia. Interestingly, the ancestors of patients originate from countries bound to the North Sea, hence the condition was termed North Sea PME (NSPME). Until now, only 20 patients have been reported in literature. Here, we provide a
Fragmentbaserad läkemedelsutveckling (FBDD) har på senare tid utvecklats som en lovande alternativ metod för att identifiera svåråtkomliga bindningsställen, såsom små fickor eller allosteriska säten. Weak affinity chromatography (WAC™) är en FBDD-metod där dissociationskonstanten kan beräknas genom att jämföra retentionstiden på en proteinkolonn med en referenskolonn. Målet med projektet är att möFragment-based drug discovery (FBDD) has in recent years emerged as an interesting method to target challenging binding sites, such as allosteric sites or small pockets. Weak Affinity Chromatography (WAC™) is a FBDD technology where dissociation constants of injected compounds are determined by comparing retention times between a protein column to a reference column. The goal of this project was t
Bakgrund: Röstbesvär förekommer ofta inom röstkrävande yrken och kan påverka arbetsförmågan påtagligt. Trots detta saknas det tillförlitliga självskattningsinstrument som specifikt fångar hur röstbesvär påverkar arbetsförmågan. Work Hoarse har utvecklats för att fylla denna lucka. Syfte: Syftet med studien var att genomföra en språklig översättning och kulturell anpassning av självskattningsinstruBackground: Voice problems are prevalent in vocally demanding professions and may impact work ability. Nevertheless, there is a lack of reliable self-assessment tools that specifically measure impact of voice disorders on work ability. The self-assessment tool Work Hoarse was developed to address this gap. Aim: This study aimed to translate and adapt Work Hoarse linguistically and culturally into
The topic of this study is the phosphorylation dependent interaction between aquaporin 2 (AQP2) and the FERM domain of ezrin. AQP2 is an important water channel for finetuning the water content of the urine based on the needs of the body. The main way of regulating how much water is reabsorbed is by regulating the amount of AQP2 present in the apical membrane. This regulation is controlled throug
Popular Abstract in Swedish Bröstcancer är den vanligaste maligna sjukdomen hos kvinnor i världen. Årligen insjuknar mer än 7300 kvinnor i Sverige, vilket innebär nästan 30 % av all kvinnlig cancer. Mer än 80 000 kvinnor i Sverige är friska efter att ha blivit behandlade för bröstcancer, och cirka 3000 kvinnor lever med återfall av sjukdomen. Prognosen har förbättrats de senaste decennierna, delviRadiotherapy (RT) after mastectomy has been part of the treatment for early breast cancer since the 1940s. The treatment reduces the risk of loco-regional recurrences, but implies risk of late side effects that can begin decades after RT. Aims of the thesis were: - To analyse the long term effects of postmastectomy radiotherapy and systemic treatment for 1100 stage II breast cancer patients in t
The indoor climate in buildings has changed in the last decade due to more efficient climatic systems, floor heating systems and larger open floor areas with more natural light. All this has induced increasing ranges of relative humidity between different seasons. Also with decreasing relative humidity (in the winter 30-50% RH, in the summer 70-90% RH), floor-heating systems increase the temper
This thesis is about avenues (tree-lined roads – in Swedish alléer). Avenues are a characteristic landscape element in many parts of Scania. This is an object created by man with a clear visual effect in the landscape. The avenue is also something which is both nature and culture, a man-made object from nature. The purpose of the thesis is to describe, analyse and discuss the historical geograph
Pollination contributes to an estimated one third of global food production, through both the improvement of the yield and the quality of crops. Volatile compounds emitted by crop flowers mediate plant-pollinator interactions, but differences between crop varieties are still little explored. We investigated whether the visitation of crop flowers is determined by variety-specific flower volatiles u
Lactobacillus kunkeei is the most abundant bacterial species in the honey crop and food products of honeybees. The 16S rRNA genes of strains isolated from different bee species are nearly identical in sequence and therefore inadequate as markers for studies of co-evolutionary patterns. Here, we have compared the 1.5 Mb genomes of ten L. kunkeei strains isolated from all recognized Apis species and
Objective. To summarize data on deliveries after IVF performed in Sweden up to 2006. Design. Cohort study of women and children, conceived after IVF with comparisons of deliveries after IVF before and after April 1, 2001. Setting. Study based on Swedish health registers. Population. Births registered in the Swedish Medical Birth Register with information on IVF from all IVF clinics in Sweden. Meth
Barkborrar är en grupp av insekter som lever av och i vedartade växter. Vissa av barkborrarna har förmågan att angripa levande träd, och därav kan de potentiellt orsaka storskaliga skogsskador. Dessa skogsskador kan ha en betydande ekologisk inverkan på skogars ekosystem samt betydande ekonomisk inverkan för skogsägare och samhällen som är beroende av skogsbruk. I den här studien användes fenologiBark beetles are a subfamily of insects living in and breeding on woody plants. Some of the bark beetle species have the ability to attack living trees, and thereby the potential to cause major forest damage. These forest damages can have a significant ecological and economic impact to forest ecosystems and foresters. In this study, phenology models were used to compare the responses to climate ch
Med nya läkemedel, hudvårdsprodukter, stekpannor och bekämpningsmedel följer också att allt fler föroreningar släpps ut i naturen via bland annat jordbruk samt avlopp från industrier och sjukhus. Dessa föroreningar sprids till våra vattendrag, påverkar de organismer som lever där negativt och kan även förorena vårt dricksvatten. Ett läkemedel som släpps ut i naturen och som kan ses som särskilt pOrganic contaminants are present in aquatic environments and there is a need for water treatment techniques that are both efficient and practically implementable. Antibiotics are particularly problematic organic contaminants, as insufficient removal can contribute to the spread of antibiotic resistance, which can affect essential bacteria for ecosystems and cause untreatable infections in humans.
Primary aim of project: to examine if Group Weariness (GW) exists, a concept defined as a n e g a t i v e a t t i t u d e t o w a r d s w o r k i n g i n g r o u p s b a s e d o n p r e v i o u s e x p e r i e n c e s o f t h e w o r k i n g f o r m, and the meaning and consequences of the phenomenon. Secondary aim: to explore differences between those who experience GW and those who do not. In t
BACKGROUND: High-quality non-invasive imaging of the deep venous system in the thorax is challenging, but nevertheless required for diagnosis of vascular pathology as well as for patient selection and preoperative planning for endovascular procedures.PURPOSE: To compare the diagnostic quality of Gadofosveset-enhanced thoracic magnetic resonance venography, seven consecutive patients with suspected
Functional recovery is markedly restricted following traumatic brain injury (TBI), partly due to myelin-associated inhibitors including Nogo-A, myelin-associated glycoprotein (MAG) and oligodendrocyte myelin glycoprotein (OMgp), that all bind to the Nogo-66 receptor-1 (NgR1). In previous studies, pharmacological neutralization of both Nogo-A and MAG improved outcome following TBI in the rat, and n
The proton-conducting pathway of bacteriorhodopsin (BR) contains at least nine internal water molecules that are thought to be key players in the proton translocation mechanism. Here, we report the results of a multinuclear (1H, 2H, 17O) magnetic relaxation dispersion (MRD) study with the primary goal of determining the rate of exchange of these internal water molecules with bulk water. This rate
Background: The decline of child mortality during the late 19th century is one of the most significant demographic changes in human history. However, there is evidence suggesting that the substantial reductions in mortality during the era did little to reduce mortality inequality between socioeconomic groups.Objective: The aim of this study is to examine the development of socioeconomic inequaliti
Individual differences in animal behavior can be attributed to genetic as well as non-genetic influences. One mechanism by which the behavioral phenotype of an individual can be shaped is via transmission of maternal sex steroids. In this study, we examined the role of yolk testosterone (T) in controlling neophobia in 9-month-old, sexually mature zebra finches (Taeniopygia guttata). Offspring hatc
