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The clinical presentation of Alzheimer's disease (AD) varies widely across individuals but the neurobiological mechanisms underlying this heterogeneity are largely unknown. Here, we compared regional gray matter (GM) volumes and associated gene expression profiles between cognitively-defined subgroups of amyloid-β positive individuals clinically diagnosed with AD dementia (age: 66 ± 7, 47% male, M

Danon disease (DD) is a monogenic X-linked disorder characterized by cardiomyopathy, skeletal myopathy and variable degrees of intellectual disability. DD develops due to mutations in the gene encoding lysosomal-associated membrane protein 2 (LAMP2). We report on a family exhibiting the clinical phenotype comprising of hypertrophic cardiomyopathy and ventricular pre-excitation, myopia and mild myo

Sex chromosomes were discovered more than 100 years ago. They have been studied intensely from a theoretical perspective since then, giving rise to a large body of testable predictions about their evolution from autosomes. A common feature of sex chromosomes is recombination suppression between the sex chromosome copies (X and Y in male heterogametic systems, or Z and W in female heterogametic sys

Background: Migration from Thailand to Sweden has increased threefold over the last 10 years. Today Thailand is one of the most common countries of origin among immigrants in Sweden. Since the year 2000, new HIV cases are also more prevalent among Thai immigrants compared to other immigrant nationalities in Sweden. The purpose of this study was to investigate the association between knowledge and

The need of a European immigration policy within the EU appear to be evident. Until fairly recently, immigration and asylum policy was strictly the concern of every national state but since the mid-80s, a clear intensification of cooperation has taken place. The measures taken in this field the last 15 years have been concentrated on exclusion of foreigners. The Single European Act introduced an a

Executive summary Problems During the last decades the society has undergone a major change. Only some years ago organizations’ most important assets were of financial character. Some years ago the conception intellectual capital were presented in order to further explain the difference between market value and book value. This difference is a major concern for many organizations, and to solve thi

Purpose:
Identify alternative to the current air transportation routes from supply units in Asia to European customers. The authors strive to provide the department of Supply Flow & Logistics with proposals of how they can reduce their costs and environmental effects connected to transportation. The authors also strive to display and evaluate the risk connected to a change in transp

The threat or use of force in international relations has been unlawful since the UN Charter entered into force in 1945. States still had the right, though, to protect themselves in self-defence. There has, from the start, been a discussion about the extent of this right to self-defence. In UN Charter article 51 it is stated that Members have an ''inherent right of individual or collective

Popular science summary Hodgkin’s lymphoma (HL) is a common B cell lymphoma of the Western world and the therapies used to treat it have considerable side effects. Epstein Barr Virus (EBV) infection is associated with the pathogenesis of HL, though little is known about its contribution. B-lymphocyte undergoes two rounds of differentiation; first in the bone marrow where it becomes a Naïve B cell

Greenhouses and nursery-gardens is an important business in Sweden, covering a land area of 3,0 million square meters in 2011. The downside of this otherwise blooming business is however the use of so called PPPs, plant protection products, which is connected to it. Historically the use of PPPs has been widespread and the handling has been conducted in an off-hand way. During the post-war time the

Galaxies with high redshift (z) are galaxies in the early universe, and they differ from local ones. They often show more irregular morphologies and significantly different kinematic properties, as turbulent motion dominates. These early galaxies have higher gas velocity dispersion (σ) and lower rotation-to-dispersion (vrot/σ) values. Recent findings from both the JWST and the Atacama Large Millim

Detta examensarbete undersöker och jämför lönsamheten för två olika metoder för underhållsarbeten på järnväg i form av spårbyten utifrån ekonomiska och tidsmässiga aspekter. Dessa metoder är den traditionella traktormetoden och det avancerade spårbyteståget. Syftet med arbetet är att undersöka användningen av spårbyteståg och traditionella metoder vid underhållsarbeten på bana i Sverige samt när dThis thesis examines and compares the profitability of two different methods for railway maintenance work in the form of track renewal based on economic and time aspects. These methods are the tractor method and the advanced track renewal trains. The purpose of the thesis is to investigate the use of track renewal trains and tractor methods for track maintenance work in Sweden and when the former

Can we fool the molecular time? Cells in our body contain all the information needed for their structure and function, stored in the genetic material, the DNA. Like volumes of an encyclopedia, DNA is organized into chromosomes. Every time the cells divide, all chromosomes are copied, and each new cell gets one copy. But the copying mechanism is not perfect; the end parts of each chromosome -calle

From Strands to Wires All the genetic information required to develop and maintain an organism is packed tightly into the molecule known as DNA. Determining the order of the four bases, which are the building blocks of DNA, enables the identification of a DNA segment. Modern disease diagnostics use this identification method, known as DNA sequencing, to inspect genetic integrity. Thus, it is vita

Metabolism plays a crucial role in an animal’s life as it determines the amount of energy that can be allocated to growth, reproduction, and survival. The strategies an individual adopts to manage its energy budget have direct consequences to its fitness. How an animal allocates its energy will determine whether it can ensure its own survival while having a high reproductive success or neglect one

Denna uppsats avser att utreda och beskriva förutsättningarna för återvinning av betalning av en skuld enligt 4 kap 10 § KonkL och att belysa hur regleringen brukar tolkas och tillämpas. Syftet är att redogöra för innebörden av bestämmelsens rekvisit, med fördjupning i vad som avses med ordinär betalning och hur det bedöms om en betalning är att anse som ordinär eller ej. Materialet i denna uppsatThis essay intends to investigate and to describe the conditions for recovery of payment of a debt according to chapter 4 § 10 KonkL and to highlight how the regulation is usually interpreted and applied. The purpose is to explain the meaning of the provision's requisites, with an in-depth look at what is meant by ordinary payment and how it is assessed whether a payment is to be regarded as o

Uppsatsen syftar till att granska fri- och rättighetskommitténs syfte och ända mål med lagförslaget i betänkandet SOU 2025 Några frågor om grundläg gande fri- och rättigheter, samt vilka konsekvenser som det eventuellt kan medföra. Lagförslaget innebär en grundlagsändring av 2 kap. 7 § Regerings formen som stadgar en absolut rätt att som svensk medborgare inte landsför visas samt att inte fråntasThe purpose of this thesis is to examine the objectives and aims of the Com mittee in its legislative proposal presented in the Report SOU 2025:2 Some Issues Concerning Fundamental Rights and Freedoms, as well as the potential consequences that may accure from the proposal. The proposal entails a con stitutional amendment to Chapter 2, Paragraph 7 of the Instrument of Gov ernment, which establis

This study analyzed daily temperature data from 114 meteorological stations in the Qinling-Daba Mountains from 1980 to 2017, focusing on core zones (CE I ≥ 2274 m, CE II 1321–2274 m) and peripheral zones (PE I 668–1321 m, PE II < 668 m). Using 15 extreme temperature indices computed with RClimDex, we assessed the spatiotemporal patterns, trends, and response to climate warming of extreme temperatu

Stroke and anemia are both prevalent conditions with significant health burdens, yet their bidirectional relationship remains poorly understood. Anemia affects up to 29 % of stroke patients and is associated with increased worse outcomes. However, the causal nature of this association, particularly concerning different anemia subtypes, remains controversial, and there is a lack of clear targets an

BACKGROUND AND OBJECTIVE: Prostate cancer (PC) and dementia may commonly co-occur; yet, prior evidence for bidirectional associations is inconsistent. This study aims to determine the associations between PC and dementia in large population-based studies, which may further inform clinical care. METHODS: To assess the dementia risk in men with PC, a national cohort study was conducted in 178 746 me