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Measuring the properties of semiconductor nanowires with transmission electron microscopy

The extremely small feature size and total sample volume of semiconductor nanowire materials has meant that advanced techniques have been required for even the most routine sample characterization since the structures were first reported. Electron microscopy has been the technique of choice for fast and reliable determination of nanowire morphology, structure, and composition since the earliest re

The potential role of retinal cGMP-interaction partners within the degeneration mechanism causing Retinitis Pigmentosa

The eye disease Retinitis Pigmentosa (RP) represents a heterogeneous group of inherited retinal dystrophies, and it has been estimated that 1 in 3000 to 7000 people worldwide has the disease. The symptoms of RP are photoreceptor degeneration that leads to night blindness, followed by a decline in peripheral and central vision, and potential blindness. However, the mechanism(s) behind the photorece

Enrichment of charged monomers explains non-monotonic polymer volume fraction profiles of multi-stimulus responsive copolymer brushes

Multi-stimulus responsive poly(2-(2-methoxyethoxy)ethyl methacrylate-co-2-(diethylamino)ethyl methacrylate) [P(MEO2MA-co-DEA)] 80:20 mol % copolymer brushes were synthesized on planar silica substrates via surface-initiated activators continuously regenerated via electron transfer atom transfer radical polymerization. Brush thickness was sensitive to changes in pH and temperature as monitored with

Influence of molecular weight on PNIPAM brush modified colloidal silica particles

The effect of molecular weight and temperature on the phase transition and internal structure of poly(N-isopropylacrylamide) brush modified colloidal silica particles was investigated using dynamic light scattering (DLS) and small angle neutron scattering (SANS) between 15 and 45 °C. Dry particle analysis utilising transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FT

Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications

The highly infectious disease COVID-19 caused by the Betacoronavirus SARS-CoV-2 poses a severe threat to humanity and demands the redirection of scientific efforts and criteria to organized research projects. The international COVID19-NMR consortium seeks to provide such new approaches by gathering scientific expertise worldwide. In particular, making available viral proteins and RNAs will pave th

Microbial community attributes supersede plant and soil parameters in predicting fungal necromass decomposition rates in a 12-tree species common garden experiment

Although dead fungal mycelium (necromass) represents a key component of biogeochemical cycling in all terrestrial ecosystems, how different ecological factors interact to control necromass decomposition rates remains poorly understood. This study assessed how edaphic parameters, plant traits, and soil microbial community structure predicted the mass loss rates of different fungal necromasses withi

Phosphorus driven embrittlement and atomistic crack behavior in tungsten grain boundaries

We investigated the role of phosphorus (P) impurities on the fracture toughness and underlying failure mechanisms by means of classical atomistic modeling for a set of ⟨110⟩ symmetric tilt tungsten grain boundaries (GBs). This entailed the utilization of a quasi-static mode I displacement-controlled setup with cohesive zone volume elements (CZVEs) to study failure mechanisms and evaluate the fract

Exploration into Galectin-3 Driven Endocytosis and Lattices

Essentially all plasma membrane proteins are glycosylated, and their activity is regulated by tuning their cell surface dynamics. This is achieved by glycan-binding proteins of the galectin family that either retain glycoproteins within lattices or drive their endocytic uptake via the clathrin-independent glycolipid-lectin (GL-Lect) mechanism. Here, we have used immunofluorescence-based assays to

The effect of glycerol and protein structure on chemical degradation through deamidation and isomerization

Therapeutic proteins are essential in modern medicine but are often susceptible to chemical degradation during production, transportation, and storage, which can compromise functionality and even lead to immunogenicity in patients. This study investigates how the structure of the affibody GA-Z affects its chemical stability and how glycerol stabilizes the protein against deamidation and isomerizat

Same data, different analysts: variation in effect sizes due to analytical decisions in ecology and evolutionary biology

Although variation in effect sizes and predicted values among studies of similar phenomena is inevitable, such variation far exceeds what might be produced by sampling error alone. One possible explanation for variation among results is differences among researchers in the decisions they make regarding statistical analyses. A growing array of studies has explored this analytical variability in dif

NNT deficiency alters cardiac structure and function without impairing mitochondrial bioenergetics in aged mice

Proton-translocating NAD(P)+ transhydrogenase (NNT) is highly expressed in cardiac tissue, where it physiologically supports mitochondrial NADPH production. However, under certain pathological conditions, NNT may shift toward consuming the mitochondrial NADPH pool. Although NNT has been implicated in redox homeostasis, its contribution to cardiac function during aging remains uncertain. In this st

Cognitive and physical activities are associated with cognitive resilience in a memory clinic cohort

Lifestyle factors such as participation in cognitively stimulating activities and physical activity are hypothesized to foster neural connections and enhance resilience, thereby attenuating cognitive loss in the context of Alzheimer's disease (AD) and other neurodegenerative diseases. Nonetheless, the relationship between these factors and important clinical outcomes of cognition and brain atrophy

Life-cycle living standards of male-headed households: Evidence from Stockholm, 1800–80

Recent research in economic history argues for using a household life cycle standard-of-living approach that includes the income and expenses of all household members and considers fluctuations in the household over the life course. This study builds on that approach by empirically examining the development of living standards in male-headed households in Stockholm 1800–80, linking individuals and

Hemispheric Asymmetry of Amyloid Deposition Influences Asymmetric Tau Pathology in Alzheimer’s Disease

BACKGROUND: Tau pathology distribution in Alzheimer's disease (AD) shows individual spatial heterogeneity, including hemispheric asymmetry. The mechanisms underlying this asymmetry remain unclear. This study explored whether tau asymmetry is linked to reduced inter-hemispheric connectivity, potentially restricting tau spread, or reflects asymmetry in amyloid-beta (Aβ) distribution, indicating hemi

Nattaktiva fjärilsarter (Insecta: Lepidoptera) i Mittskåne – vad flyger var? : Night-active moths (Insecta: Lepidoptera) in Central Scania – what flies where?]

Although the moth fauna of South Sweden is relatively well known, information about the habitat preferences of species is scarce. To fill this gap and document the relative richness and conservation value of different habitats, 32,683 moth were caught in light traps at >200 sites in Central Skåne (prov. Scania). The relative frequency of species, major taxonomic groups and species with different f

Towards a Self-sustained Detached House in Bangladesh

Bangladesh is one of the most densely populated areas in the world, and Rapid urbanization has been a notable trend, with the urban population increasing from 5% to 42% between 1972 and 2023. This internal migration has led to a surge in demand for housing in cities like Dhaka, Chittagong, Sylhet, and Khulna. It is found from the Bangladesh Bureau of Statistics (BBS) that each year, 200,000 units

Ett utile dulci för ungdom : Ungdomens bibliotek som bokserie och förlagssatsning

The Swedish publishing house Svensk läraretidnings förlag published the extensive book series Barnbiblioteket Saga (the Children’s Library Saga) between 1899 and 1970. In this article, the publisher’s less extensive book series Ungdomens bibliotek (the Library of Youth) is analysed as an example of the marketing techniques that the publishing house used to reach different target groups. The articl

The male bias can be attenuated in reading : on the resolution of anaphoric expressions following gender-fair forms

Despite the increased use of different types of gender-fair forms in French, studies investigating their interpretation in context remain few. To fill this gap, we conducted a pre-registered study using a timed sentence evaluation task to examine speakers' possibilities to establish an anaphoric relationship between a gendered anaphoric expression (women or men) and non-stereotyped role nouns as a

Do Nitrogen and Phosphorus Additions Affect Nitrogen Fixation Associated with Tropical Mosses?

Tropical cloud forests are characterized by abundant and biodiverse mosses which grow epiphytically as well as on the ground. Nitrogen (N)-fixing cyanobacteria live in association with most mosses, and contribute greatly to the N pool via biological nitrogen fixation (BNF). However, the availability of nutrients, especially N and phosphorus (P), can influence BNF rates drastically. To evaluate the

Comparison of hamstring transfer with hamstring lengthening in ambulatory children with cerebral palsy : further follow-up

BACKGROUND: Overactivity or contractures of the hamstring muscles in ambulatory children with cerebral palsy (CP) can lead to either a jump gait (knee flexion associated with ankle plantar flexion) or a crouch gait (knee flexion associated with ankle dorsiflexion). Hamstring lengthening is performed to decrease stance knee flexion. However, this procedure carries the potential risk of weakening hi