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3,4-Dideoxyglucosone-3-ene (3,4-DGE): A cytotoxic glucose degradation product in fluids for peritoneal dialysis

Background. Bioincompatible glucose degradation products (GDPs) in fluids for peritoneal dialysis (PD) develop during sterilization and storage. Their biological activity has successfully been monitored through the use of various in vitro methods but their molecular and chemical nature is less well understood. Many GDPs are highly reactive carbonyl compounds. Although some of the identified GDPs a

Intumescent coating surface temperature measurement in a cone calorimeter using laser-induced phosphorescence

Intumescent coating acts as a thermal barrier for construction materials during fire hazards. The coating has the ability to expand by a factor of 40 or more during heat exposure. However, due to its fragile consistence, no physical or optical measurement technique has previously been able to measure the coating surface temperature during expansion. This is undesirable since without accurate infor

Regulation of decomposition and methane dynamics across natural, commercially mined, and restored northern peatlands

We examined aerobic and anaerobic microbial carbon dioxide (C02) and methane (CH4) exchange in peat samples representing different profiles at natural, mined, mined-abandoned, and restored northern peatlands and characterized the nutrient and substrate chemistry and microbial biomass of these soils. Mining and abandonment led to reduced nutrient and substrate availability and occasionally drier co

Vaccination technique, PPD reaction and BCG scarring in a cohort of children born in Guinea-Bissau 2000-2002

The rates of positive tuberculin skin test (TST) reactions and BCG scarring after BCG vaccination vary between studies and populations. Tuberculin reactivity and BCG scarring may be related to better child survival in low-income countries. We therefore studied determinants for TST reaction and scarring in Guinea-Bissau. In a cohort of children born in suburban Bissau from March 2000 to July 2002,

A new device to study ex-vivo the effects of extracorporeal photochemotherapy on the immune system

Extracorporeal photochemotherapy (ECP) is a medical procedure effective in the treatment of several different T-cell mediated diseases such as cutaneous T-cell lymphoma and Graft-versus-Host Disease. During ECP treatment the patient's blood is processed by means of a cell separator to collect leukocytes (leukapheresis), mostly lymphocytes and monocytes, which are then incubated with the photoactiv

Liver-specific contrast media for MRI and CT experimental studies

MRI and CT are modalities appropriate for liver imaging. To obtain higher sensitivity in diagnoses of focal lesions in the liver, contrast media (CM) are used. Non-specific extracellular CM are not optimal as they rapidly diffuse into both normal tissue and tumorous tissue. By two different mechanisms, the hepatobiliary route and targeting to the reticuloendothelial system, agents may accumulate i

Architecture and sedimentation of outwash fans in front of the Myrdalsjokull ice cap, Iceland

In this study, we introduce the architecture and style of sedimentation of two outwash fans in front of the Myrdalsjokull ice cap, central south Iceland, that broaden different types of ice-marginal sedimentation. At Kotlujokull, a southeastern outlet of the ice cap, fan formation was monitored from the late 1970s to 2002; thus, the style of sedimentation is well understood and the relationship to

Transport of Arsenic and Heavy Metals to Lake Poopó - Bolivia Natural Leakage and Anthropogenic Effects

Bolivia, a country located in the center of South America, has in the west part an Andean region, where the Poopó Lake is located. The area has many mineral resources, and thus since thousands of years,mining activity has had a large importance; however, mainly since colonial times, the extraction of these resources has been indiscriminate and the region of the Poopó Lake, has suffered the consequ

The effect of nitrogen deposition on nitrification, carbon and nitrogen mineralisation and litter C : N ratios in oak (Quercus robur L.) forests

The present study addresses the question why there is a positive relationship between nitrogen deposition and potential net nitrogen mineralisation and nitrification in oak (Quercus robur L.) forest soils in south Sweden (Falkengren-Grerup et al., 1998), and how this is related to the carbon mineralisation. We tested three hypotheses based on European studies (Persson et al., 2000a,b) that postula

Injury-induced activation of vascular smooth muscle cells. Role of specific gene expression and intracellular signalling pathways

Popular Abstract in Swedish Den vanligaste dödsorsaken i västvärlden är hjärt-kärlsjukdom. Därför finns det ett stort intresse att undersöka vilka faktorer som är av avgörande betydelse för att vi ska utveckla t.ex ateroskleros (åderförkalkning). Spelar livsstil och matvanor någon roll eller är det helt och hållet genetiskt betingat? Utvecklingen av förebyggande åtgärder, operationsteknik och postMigration and proliferation of smooth muscle cells (SMC) are important events in the development of atherosclerosis and restenosis following angioplastic surgery. It is important to gain further knowledge about the mechanisms regulating SMC form and function in order to understand the underlying disease process. In this thesis I have used cultured rat aortic SMC and analysed how these cells respon

Aqueous polymer two-phase systems formed by new thermoseparating polymers

A set of new polymers that can be used as phase forming components in aqueous two-phase systems is presented. All polymers studied have thermoseparating properties i.e. form one separate polymer enriched phase and one aqueous solution when heated above the critical temperature. This property makes the polymers attractive alternatives to the polymers used in traditional aqueous two-phase systems su

Prostacyclin reduces elevation of intracranial pressure and plasma volume loss in lipopolysaccharide-induced meningitis in the cat.

BACKGROUND: Severe meningitis may compromise cerebral perfusion through increases in intracranial pressure (ICP) and through hypovolemia caused by a general inflammation with systemic plasma leakage. From its antiaggregative/antiadhesive and permeability-reducing properties, prostacyclin (PGI2) is a potential adjuvant treatment in meningitis, but previously published data have been ambiguous. The

Intestinal barrier function in health and disease

Popular Abstract in Swedish Tarmslemhinnans förmåga att ta upp olika näringsämnen från tarmen är essentiell för vår överlevnad men den utgör också en viktig skyddsbarriär mellan tarminnehållet och blodbanan. Tarminnehållet består till stor del av bakterier och ej nedbrutna födoämnesmolekyler vilka kan ge upphov till patologiska tillstånd om de passerar tarmväggen. Ökad kunskap om tarmens funktion The intestinal epithelium has the dual function of absorbing nutrients and water as well as being a barrier to potentially harmful substances such as macromolecules and bacteria. In the present thesis the barrier function of the intestinal mucosa was studied in vitro in Ussing diffusion chambers. Intestinal permeability to different-sized molecules was investigated and compared in various intesti

Preliminary Waste Management Plan of European Spallation Source

The European Spallation Source (ESS) is the European common effort in designing and building a next generation large-scale user facility for studies of the structure and dynamics of materials. The proposed schematic layout of the ESS facility is based on a linear driver (linac) directing the proton beam (5 MW of 2.5 GeV) of 2.8 ms long pulses with a 20 Hz on a tungsten target where neutrons are pr

A clinically confirmed family history for early myocardial infarction is associated with increased risk of obesity, insulin resistance and metabolic syndrome.

OBJECTIVE:: The risk factor pattern underlying a parental history of myocardial infarction (MI) is incompletely understood. We examined whether a parental history of clinically verified early MI may promote development of insulin resistance, obesity and the metabolic syndrome (MetS). METHODS:: One hundred and seventy-four offspring to patients with clinically verified MI before 60 years of age i

Tonsillar ectopia in idiopathic scoliosis: does it play a role in the pathogenesis and prognosis or is it only an incidental finding?

ABSTRACT: BACKGROUND: There is an ongoing controversy about the significance of tonsillar ectopia among patients with idiopathic scoliosis (IS). AIM: To find out if tonsillar ectopia occurs more frequently among patients with IS and if it plays any etiological or prognostic role in IS. STUDY DESIGN: Retrospective study. METHODS: Retrospective analysis of 155 consecutive spine MRIs (79 patients wit

Accelerator physics studies of the MAX-lab storage rings

Popular Abstract in Swedish Synkrotronstrålning genereras när laddade partiklar som färdas med relativistiska hastigheter böjs av i ett magnetfält. Under accelerationen som böjningen utgör genereras synkrotronstrålning i en smal kon i partikelns framåtriktning. Denna fotonstrålning är intensiv och utgör en användbar prob inom materialforskningen. Genom att belysa material med synkrotronstrålningenWithin research, synchrotron radiation is a highly useful probe for the study of materials, their properties and structures. Currently, no other radiation source allows the combination of high intensity and short wavelengths. The 3rd generation light sources currently in use for the production of synchrotron radiation are however considerable investments: for already existing facilities this makes

Ett offer för omständigheterna - En undersökning av hur kriminella kvinnor bedöms i straffprocessen

Vad är det som gör att man begår ett brott? Vad är det för slags person som begår ett brott? Kriminella personer har alltid varit ett intresse för forskning och allmänheten. Det finns förutfattade meningar om hur en kriminell person ser ut eller beter sig. Samtidigt finns det en lika tydlig bild av hur en kvinna eller man ska se ut eller bete sig. En kriminell kvinna går emot alla förväntningar meWhat does it take for a person to commit a crime? What kind of person commits a crime? Offenders have always been interesting for both research and the society. There is a preconceived notion on how an offender should look or act like. At the same time, being a woman or a man comes with equal preconceptions. However, a female offender goes against all expectations of how an offender should act and

Laglottens aktualitet - Från blodsband till sociala familjekonstellationer

Den svenska successionsrätten innefattar en rätt för bröstarvingar att erhålla en laglott. Bestämmelserna har blivit anklagade för att vara föråldrade och har varit omdebatterad såväl i media som i riksdagen. Följande uppsats kommer att undersöka om laglotten har blivit föråldrad och utröna vilka argument som kan tänkas motivera ett bibehållande av lagstiftningen. Syftet är att se hur gällande rätThe Swedish law of succession includes a right for the direct heir to retain a part of the heritage if the deceased have drawn a will. This phenomenon is called statutory share of inheritance (in Swedish: laglott). The regulations have been accused of being out-of-date and have been up for debate in both media as well as in the parliament. Following essay will examine if the statutory share is out