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Aims: Real-time perfusion (RTP) adenosine stress echocardiography (ASE) can be used to visually evaluate myocardial ischaemia. The RTP power modulation technique angio-mode (AM), provides images for off-line perfusion quantification using Qontrast (R) software, generating values of peak signal intensity (A), myocardial blood flow velocity (beta) and myocardial blood flow (Ax beta). By comparing re
Background-beta-Adrenergic stimulation is the main trigger for cardiac events in type 1 long-QT syndrome (LQT1). We evaluated a possible association between ion channel response to beta-adrenergic stimulation and clinical response to beta-blocker therapy according to mutation location. Methods and Results-The study sample comprised 860 patients with genetically confirmed mutations in the KCNQ1 cha
Aims: It is well established that the main cause of the development of cardiovascular disease can be found in unhealthy lifestyle habits. In our study, we wanted to explore the long-term predictors of self-reported lifestyle changes in a middle-aged population after screening for cardiovascular risk factors 10 years earlier. Methods: We conducted a 10-year follow-up telephone interview on self-rep
To compare the long-term outcome after percutaneous coronary intervention with onew-generation' drug-eluting stents (n-DES) to oolder generation' DES (o-DES), and bare-metal stents (BMS) in a real-world population. We evaluated 94 384 consecutive stent implantations (BMS, n 64 631; o-DES, n 19 202; n-DES, n 10 551) in Sweden from November 2006 to October 2010. All cases of definite stent thrombosi
Climate change and disasters are among today’s most pressing issues. The damage caused by the world-wide increase in disasters is staggering, with the urban poor being most at risk. Disasters make their al-ready precarious living conditions worse, creating a vicious circle of poverty. More and more attention has thus been given to the need to address changing climatic conditions and disaster risk
Background. Increased levels of nitric oxide (NO) and the exudations of plasma proteins to the airway lumen have both been considered characteristics of airway inflammation. The aim of the present study was to investigate a possible relationship between nasal NO concentrations and acutely induced exudative inflammation of the nasal mucosa. Methods: Twelve healthy non-allergic subjects participated
Popular Abstract in Swedish Avhandlingen innehåller sju artiklar. Här presenteras ett nytt koncept för att beskriva hur fukt transporteras i porösa material. Detta bygger på införandet av en äkta flödespotential, Kirchhoff's potential. Betraktelsesättet täcker hela processen från mätning av materialdata till numerisk beräkning av fukttransport. Modeller för beräkning av fuktinträngning vid stegäThe work presented in this thesis is focused on the development of the new concept to describe isothermal moisture transport using Kirchhoff potentials. The first four papers deal with moisture transport in porous media using Kirchhoff potentials. The last three papers deal with wood. Here the theory is extended to the case of anisotropic moisture transport. The seven papers have the following con
Absolute regional cerebral blood flow (CBF) was measured in ten healthy volunteers, using both dynamic susceptibility-contrast (DSC) magnetic resonance imaging (MRI) and Xe-133 SPECT within 4 h. After i.v. injection of Gd-DTPA-BMA (0.3 mmol/kg b.w.), the bolus was monitored with a Simultaneous Dual FLASH pulse sequence (1.5 s/image), providing one slice through brain tissue and a second slice thro
Background: Physiotherapy research concerning interventions for children with CP is often focused on collecting evidence of the superiority of particular therapeutic methods or treatment modalities. Articulating and documenting the use of theory, instrumentation and research design and the assumptions underlying physiotherapy research interventions are important. Physiotherapy interventions focusi
Rationale and Objectives: To investigate for differences in metabolic concentrations and ratios between patients with systemic lupus erythematosus (SLE) without (group SLE) and those with neurological symptoms (group NPSLE) compared to a healthy control (group HC) in three normal-appearing brain regions: the frontal white matter, right insula (RI), and occipital gray matter and whether changes in
Knowledge concerning the molecular mechanisms governing the influence of non-coding RNAs on protein production has emerged rapidly during the past decade. Today, two main research areas can be identified, one oriented toward the use of artificially introduced siRNAs for manipulation of gene expression, and the other one focused on the function of endogenous miRNAs. In both cases, the active molecu
Popular Abstract in Swedish Gliom är den vanligaste typen av hjärntumörer hos vuxna. Den mikroskopiska klassificeringen av de olika formerna av gliom är subjektiv och i vissa fall t.o.m. felaktig, vilket leder till klinisk oklarhet som kan hindra utvecklingen av terapier som riktas mot speciella egenskaper som kännetecknar speciella typer av gliom. EGFR och PDGFRA är en cellreceptor som har en cenGlioma is the most common type of primary tumor in the adult central nervous system (CNS). However, the current classification of gliomas is highly subjective and even inaccurate in some cases, which leads to clinical confusion and hinders the development of targeted therapies. EGFR and PDGFRA play crucial roles in glia development and glioma pathogenesis. In this thesis we aim to establish a glia
Popular Abstract in Swedish Denna avhandling fokuserar en religiös aktör i det civila samhället under en konfliktfylld tid. Judiska, muslimska och kristna barn studerade tillsammans i anglikanska missionsskolor under den brittiska mandattiden i Palestina. Jerusalem var då etniskt och religiöst delat. Det anglikanska utbildningsprojektet var en del av den Anglikanska kyrkans försök att främja konflThis thesis concerns a religious actor in the civil society in times of violent conflict. During the British Mandate period in Palestine, Jewish, Muslim and Christian children studied together at Anglican missionary schools. At this time Jerusalem bore all the imprints of ethnic and religious separation and division. The Anglican educational project became part of the efforts made by the Anglican
In the developed countries the public expect society to be prepared for, and step in, if something out of the ordinary happens. This public pressure appears to have increased the demand for crisis preparedness planning. In crisis management the local authority serves as the first line of defence and will more or less always be involved in responding to crises. It is therefore important to study ho
Popular Abstract in Swedish Cystisk fibros (CF) är den vanligaste svåra ärftliga metabola sjukdomen i den vita befolkningen. I Sverige drabbar den ca 1:4500-6500 individer men i många länder har den en högre incidens på ca 1:2000-3000. Trots en klart förbättrad överlevnad det senaste decenniet är det fortfarande många som dör i ung ålder. Den vanligaste dödsorsaken är lungkomplikationer till följdCystic fibrosis (CF) is the most common severe autosomal recessive disorder among Caucasians and is caused by mutations of the chloride channel, CFTR (cystic fibrosis transmembrane conductance regulator) gene. Despite a markedly improved median survival many CF patients still die at a young age. The chronic lung disorder is the main cause of mortality. Endogenous and exogenous factors, which may c
Popular Abstract in Swedish Autoimmuna sjukdomar såsom reumatoid artrit (RA) och multipel skleros (MS) uppkommer av en felaktig immunrespons mot kroppens egen vävnad. Orsaken är okänd trots enormt mycket forskning om ämnet. Ett sätt att öka kunskapen vore att identifiera de gener som bidrar till sjukdomarna. För sådana relativt vanliga, komplexa sjukdomar finns det inte en gen som ?styr? sjukdomarAutoimmune diseases are dependent on both genetic and environmental factors in complex interplay. They arise from a faulty immune response against self-antigens, and causes great suffering in affected individuals. Despite large efforts and hundreds of thousands of research articles published, the disease etiologies remain largely unknown. Knowledge of which genes are involved and how they interact
BACKGROUND: Situational needs of health care facilities inform the optimal allocation of resources and quality improvement efforts. This study examines surgical care delivery metrics at a tertiary care institution in Liberia. METHODS: We retrospectively reviewed operative and ward logbooks from January 1 to December 31, 2012. Data parameters included patients' age, diagnosis, procedure, mortality,
Aims/hypothesis We aimed to identify which surrogate index of insulin sensitivity has the strongest correlation with the reference measurement, the hyperinsulinaemic-euglycaemic clamp (HEC), to determine which surrogate measure should be recommended for use in large-scale studies. Methods A literature search (1979-2012) was conducted to retrieve all articles reporting bivariate correlations betwee
Previous genome-wide association (GWA) studies have identified SNPs associated with areal bone mineral density (aBMD). However, this measure is influenced by several different skeletal parameters, such as periosteal expansion, cortical bone mineral density (BMDC) cortical thickness, trabecular number, and trabecular thickness, which may be under distinct biological and genetic control. We have car
BACKGROUND: Cancer of unknown primary (CUP) is a fatal cancer for which incidence trends have changed but detailed survival trends remain unexplored. These could point out successful diagnostic and therapeutic approaches. We investigate survival trends in CUP according to histology, locations of metastases and site-specific causes of death. PATIENTS AND METHODS: A total of 20,523 CUP patients with
