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BACKGROUND AND PURPOSE: The European Cooperative Acute Stroke Study (ECASS) III trial and Safe Implementation of Thrombolysis in Stroke-International Stroke Thrombolysis Register (SITS-ISTR) data were published in 2008. Riks-Stroke, the Swedish Stroke Register, was used to explore how thrombolysis in the 3- to 4.5-hour window has been spread in different hospitals and patient groups and what effec
Identification of targets for apoptosis induction is important to provide novel therapeutic approaches in breast cancer. Our earlier studies showed that down regulation of protein kinase C δ (PKCδ) induces death in breast cancer cells. In this study we set out to identify previously unrecognized apoptosis regulators in breast cancer cells. To identify candidates, global expression analysis with mi
Exposure to ultrafine particles (UFP) may have adverse health effects. Central monitoring stations do not represent the personal exposure to UFP accurately. Few studies have previously focused on personal exposure to UFP. Sixty non-smoking residents living in Copenhagen, Denmark were asked to carry a backpack equipped with a portable monitor, continuously recording particle number concentrations (
Autoantibodies against the newly established autoantigen in type 1 diabetes, zinc transporter 8, ZnT8, are presented as two types, ZnT8RAb and ZnT8WAb. The rs13266634 variant of the SLC30A8 gene has recently been found to determine the type of ZnT8Ab. The aim of this study was to explore the impact of this genetic variant and the ZnT8Ab on the residual beta-cell function during disease progression
Resource availability and limiting factors for bacterial growth during early stages of soil development (8-138 years) were studied along a chronosequence from the glacial forefield of the Damma glacier in the Swiss Alps. We determined bacterial growth (leucine incorporation) and we investigated which resource (C, N or P) limited bacterial growth in soils formed by the retreating glacier. The latte
Supermacroporous monolithic columns with CU2+-IDA ligands have been successfully used for chromatographic separation of different types of microbial cells. The bed of monolithic matrix is formed by a cryogel of poly(acrylamide) cross-linked with methylenebis(acrylamide) and has a network of large (10- 100 mu m) interconnected pores allowing unhindered passage of whole cells through the plain cryog
We studied the role of arachidonic acid metabolites, histamine, and 5-HT in airway responses to trimellitic anhydride (TMA) in actively sensitized guinea pigs. Sensitization was produced by two intradermal injections of free TMA (0.1 ml of 0.3% TMA in corn oil). After 21 to 28 days, guinea pigs were anesthetized and challenged with intratracheal instillation of 0.5% TMA conjugated to guinea pig se
Bone morphogenetic protein-2 (BMP2) plays a key role in bone formation and maintenance. Studies of polymorphisms within the gene in relation to bone mineral density (BMD) and fracture have been inconsistent. Our aim was to investigate associations between polymorphisms in the BMP2 gene and bone mass, fracture, and quantitative ultrasound (QUS) measures at different stages of skeletal development.
PURPOSE: To study possible differences in mechanical properties between central (abdominal aorta) and more peripheral (common carotid and common femoral) arteries validating an earlier non-invasive study in children showing that central arteries are more distensible than peripheral ones. As invasive blood pressure was needed, but ethically impossible to obtain in children in an experimental settin
Objective: To describe anthropometric characteristics of participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). Design: A cross-sectional analysis of baseline data of a European prospective cohort study. Subjects: This analysis includes study populations from 25 centres in nine European countries. The British populations comprised both a population-based and a 'he
The combination of Doppler tissue imaging and myocardial contrast echocardiography has the potential to provide information about motion and perfusion of the myocardium in a single examination. The purpose of this study was to establish how the presence of ultrasound contrast agent (UCA) affects measurements of Doppler tissue velocities in vivo and in vitro. We performed echocardiography in 12 pat
PURPOSE: To elucidate the role of leucine-rich proteoglycans lumican and fibromodulin in the sclera. METHODS: Lumican- and fibromodulin-null heterozygous mice were intercrossed to obtain wild-type (Lum(+/+)Fmod(+/+)), lumican-null (Lum(-/-)Fmod(+/+)), fibromodulin-null (Lum(+/+)Fmod(-/-)), and double-null (Lum(-/-)Fmod(-/-)) littermates. Axial length was measured on enucleated whole eyes, and ocul
Objectives: To evaluate costs, benefits, and cost effectiveness of tumour necrosis factor inhibitor treatment over one year in routine clinical practice. Materials and methods: At four rheumatology units in southern Sweden treatment of 160 consecutive patients with RA was started with either etanercept or infliximab. The economic analysis was based on 116 patients with complete data who received
Guidelines are used in information and quality management systems to ensure high quality by supporting design, production and communication processes. These guidelines can be presented as a conventional system on an intranet suitable for printouts, visualized as a traditional text-based report with a list of headings accompanied by tables and pictures or presented as paper documents in manuals or
Patients with mild asthma may benefit from increasing their inhaled corticosteroid dose, adding a tong-acting beta(2)-agonist, or both. This study assessed the cost-effectiveness of these options. Patients aged greater than or equal to12 years with mild-to-moderate persistent asthma (n = 1272) were randomised to twice-daily, double-blind treatment with budesonide 100 mug, budesonide 100 mug plus f
OBJECTIVE: To assess whether intravascular ultrasound (IVUS), used systematically in a series of patients with abdominal aortic aneurysms (AAA), is a feasible control procedure to ensure correct transfemoral placement of endovascular stent grafts (TPEG). DESIGN: Descriptive study. MATERIALS AND METHODS: Fourteen patients with infrarenal aortic aneurysms were treated by the placement of one tube gr
Popular Abstract in Swedish Låg temperatur begränsar i stor utsträckning överlevnad och expansion av vegetation. Under senare år har samverkan mellan låg temperatur och hög instrålning, som leder till försämrad fotosynteseffektivitet, rönt stor uppmärksamhet. I denna avhandling tillämpas nya metoder för att relatera rumsliga variationer i temperatur och instrålning till fotosynteseffektivitet ochLow temperature has a large impact on the survival and distribution of plants. Interactive effects with high irradiance lead to cold-induced photoinhibition, which may impact on the establishment and growth of tree seedlings. In this thesis, novel approaches are applied for relating the spatial variability in low temperature and irradiance to photosynthetic performance and growth of tree seedlings
Purpose: The aim of the study was to evaluate the effect of perioperatively systemically administered betamethasone on nerve recovery (within or outside a confined space) after induced nerve crush injury. Materials and Methods: The sciatic nerve of 40 adult Wistar rats was crushed. In half of the animals, the injured nerve was entrapped in a silicone tube to simulate the environment of a closed sp
Objective. Most risk factors are similar for abdominal aortic aneurysm (AAA) and atherosclerosis, e.g. smoking, male gender, age, high blood pressure, hyperlipidemia. Diabetes mellitus however, is a risk factor for atherosclerosis, but diabetic patients seldom develop AAA. The reason for this discrepancy is unknown. Increased aortic wall stress seems to be all etiologic factor in the formation, gr
Popular Abstract in Swedish Värmebehandling (termoterapi) av tumör baseras på kunskap om den celldödande effekten av värme. Den har begränsats av svårigheten att kontrollera temperaturutbredningen så att en selektiv och tillräcklig effekt erhålls, och detta gäller särskilt djupt belägna tumörer. Interstitiell laser termoterapi (ILT) med Nd:YAG laser är en ny behandlingsform, som ger de tekniska föInterstitial laser thermotherapy (ILT) is a method well suited for selective local destruction of malignant tumours. In the present work, a laser thermotherapy system based on feedback temperature control of energy delivery (through computerised feedback system) was developed. Temperature control was excellent in experiments without carbonization and with preserved light penetration, whereas tempe
