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Pheochromocytomas (PCCs) and paragangliomas (PGLs) are rare neuroendocrine tumors. PGLs can further be divided into sympathetic (sPGLs) and head-and-neck (HN-PGLs). There are virtually no treatment options, and no cure, for metastatic PCCs and PGLs (PPGLs). Here, we composed a tissue microarray (TMA) consisting of 149 PPGLs, reflecting clinical features, presenting as a useful resource. Mutations
Cisplatin, a platinum-based chemotherapeutic agent, is widely used as a front-line treatment for several malignancies. However, treatment outcomes vary widely due to intrinsic and acquired resistance. In this study, cisplatin-perturbed gene expression and pathway enrichment were used to define a gene signature, which was further utilized to develop a cisplatin sensitivity prediction model using th
The aim of this study was to find sorption filters with a capacity to remove heavy metals from landfill leachate. Initially a batch test was performed with granular activated carbon, CAP meal derived from animal bones, iron fines, a non-metallic part of bottom ash from a municipal solid waste incineration plant, metal residues from the same bottom ash, lime stone and peat. Activated carbon, CAP me
The first analysis to our knowledge of the optical data storage density of photon-echo storage is presented. Mainly considering signal-to-noise ratio performance, we calculate the obtainable storage density for data storage and processing using photon echoes to be approximately 100 times the theoretical limit for conventional optical data storage. This limit is similar to that theoretically calcul
Staphylococcal enterotoxin H (SEH) is a bacterial superantigen secreted by Staphylococcus aureus. Superantigens are presented on the MHC class II and activate large amounts of T cells by cross-linking APC and T cells. In this study, RT-PCR was used to show that SEH stimulates human T cells via the V domain of TCR, in particular V10 (TRAV27), while no TCR V-specific expansion was seen. This is in s
Some years ago terminal pumping for the gas stripper system at the 3 MV Lund Tandem Pelletron accelerator was installed and charge state distribution measurements using the new installation were reported. Since then, new modifications of the mechanical design of the stripper system have been made. The results of pressure profile measurements as well as the results of charge state distribution meas
A multitude of crucial chemical phenomena occur in the region where an aqueous medium meets a more apolar environment. The change in the character of the medium can be due to a macroscopic phase boundary, but it is much more common that it is due to the presence of an aggregate, a macromolecule or even an apolar molecule of moderate size. One aspect of such a transition region from polar to apolar
An automated system was developed for analysis of non-polar and polar ionisable compounds at trace levels in natural water. Sample work-up was performed in a flow system using two parallel membrane extraction units. This system was connected on-line to a reversed-phase HPLC system for final determination. One of the membrane units was used for supported liquid membrane (SLM) extraction, which is s
Hereditary cystatin C amyloid angiopathy (HCCAA) is a dominantly inherited disease characterized by amyloidosis, dementia and fatal cerebral hemorrhage of young adults. A method for rapid and simple diagnosis of HCCAA is described. It is based upon oligonucleotide-directed enzymatic amplification of a 275-bp genomic DNA segment containing exon 2 of the cystatin C gene from a blood sample, followed
Most studies of gesture production to date have been based on analyses of narrative discourse in face-to-face interaction. Issues such as the relationship between gesture types and the content of speech, as well as the distribution of particular gesture types across given narrative sequences have been investigated. Depictive gestures, e.g., are frequent where the content concerns the description o
The spread of invasive, particularily bird-sown and red-fruited, non-native woody species in open calcareous conifer forests in Sweden is discussed and examplified with a survey of pine forests by Åhus in E Scania, southern-most Sweden. The survey area is a pine forest planted ca 100 years ago on calcareous sanddunes within which an area with private homes with gardens was built in the 1960’s to 1
Recent studies document a 30-year decline in various measures of entrepreneurship in the U.S. Using detailed Swedish employer-employee data over the period from 1990 to 2013, we find young firms to be more prominent in the Swedish business sector than in the U.S. business sector. Young Swedish firms, aged five years or less, account for more than half of all firms during this period. We also obser
Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) has been clinically validated as a target for antimalarial drug discovery, as a triazolopyrimidine class inhibitor (DSM265) is currently undergoing clinical development. Here, we have identified new hydroxyazole scaffold-based PfDHODH inhibitors belonging to two different chemical series. The first series was designed by a scaffold hoppi
“Upper tail knowledge”, embodied by knowledge elites, has been suggested to be a driving force of industrialization and development, yet measuring it remains problematic. Despite some recent innovations, much empirical work continues to rely on measures of “average” or “non-upper tail” human capital such as literacy and years of schooling. We thus turn to perhaps unique sources from Denmark and No
In this article we analyse the actions of Royal Dutch/Shell (since 2021, Shell) considering the campaign against them and their operations in Nigeria in the mid-1990s. Using the concept counter-frames we analyse Shell's internal documentation of the campaign to understand how a multinational extractive industry engaged in disputes of legitimacy and against critiques of their operations. Focusing o
Background: Inhomogeneous Magnetization Transfer (ihMT) is an emerging, uniquely myelin-specific magnetic resonance imaging (MRI) contrast. Current ihMT acquisitions utilise fast Gradient Echo sequences which are among the most acoustically noisy MRI sequences, reducing patient comfort during acquisition. We sought to address this by modifying a near silent MRI sequence to include ihMT contrast. M
