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Bradykinin-induced airflow obstruction and airway plasma exudation: effects of drugs that inhibit acetylcholine, thromboxane A2 or leukotrienes

1 The mechanisms behind bradykinin-induced effects in the airways are considered to be largely indirect. The role of cholinergic nerves and eicosanoids, and their relationship in these mechanisms were investigated in guinea-pigs. 2 The role of cholinergic nerves was studied in animals given atropine (1 mg kg-', i.v.), hexamethonium (2 mg kg-', i.v.), or vagotomized. To study the role of eicosanoid

Term breech delivery in Sweden: mortality relative to fetal presentation and planned mode of delivery

Objectives. To compare perinatal and infant mortality in breech and cephalic presentations and between planned vaginal and cesarean section (CS) breech deliveries in Sweden. Methods. The study comprised two parts. Study A is a national cohort study for the period 1991-2001, including 22 549 breech presentations and 875 249 cephalic presentations born at >= 38 completed weeks. Study B is a case-con

Evaluation of the tissue microarray technique for immunohistochemical analysis in rectal cancer.

BACKGROUND: Immunohistochemical staining for tumor-associated proteins is widely used for the identification of novel prognostic markers. Recently, a tissue-conserving, high-throughput technique, tissue microarray, has been introduced. This technique uses 0.6-mm tissue core biopsy specimens, 500 to 1000 of which are brought into a new paraffin array block, which can be sectioned up to 100 times. M

Serum levels of citalopram and its main metabolites in adolescent patients treated in a naturalistic clinical setting

The prescribing of selective serotonin reuptake inhibitors for adolescents is extensive despite the fact that there are few pharmacokinetic (PK), efficacy, safety, or tolerability studies on this group. This study reports the PK findings from two trials in adolescents treated with citalopram (CIT) in naturalistic clinical settings: one retrospective and one prospective. The aim of our study was to

Americanitis : Amerika som sjukdom eller läkemedel : Svenska berättelser om USA åren 1900-1939

Popular Abstract in SwedishAvhandlingen syftar till att studera svenska föreställningar om USA och det amerikanska och genom dem den svenska självbilden och olika visioner om den svenska framtiden i den offentliga debatten under perioden c:a 1900-1939, då USA var omdiskuterat som en mycket betydelsefull ny nation men ännu inte erkänt som en obestridlig supermakt. Den söker visa hur föreställningarThe aim of this thesis is to study Swedish notions of the USA and of things American and through them the Swedish self-image and the ideas about the Swedish future as seen in public debate in the period c. 1900-1939, when the USA was the subject of a good deal of discussion as an up-and-coming nation of great importance but was not yet recognized as an indisputable super power. It tries to demonst

Radiation effects on S-phase duration, labelling index, potential doubling time and DNA distribution in head and neck cancer xenografts

The effect of irradiation on S-phase duration (Ts), labelling index (LI), potential doubling time (Tpot), and cell cycle phase distributions was determined by DNA flow cytometry in xenografted human squamous cell carcinoma of the head and neck (SCCHN). Tumours were treated with a single dose of 3 Gy, and excised at intervals over a 90-h period. Six hours before each excision the tumours were label

Effect of cysteine mutations on direct electron transfer of horseradish peroxidase on gold

Surface exposed cysteines were genetically engineered in the structure of recombinant horseradish peroxidase (rHRP). Recombinant forms of HRP with either a His-tag or a Strep-tag at the C-terminus were produced, which additionally had cysteines at positions 57, 189 or 309 (C-terminus) of the polypeptide chain. An E coli expression system was exploited. The effect of these mutations on the direct e

Effectiveness of a light-weight ice-vest for body cooling in fire figther´s work

The aim of the present study was to examine the effects of wearing a light-weight ice-vest (1 kg, water) on physiological and subjective responses in fire fighter’s work. The experiments were carried out in a climatic chamber, in a container under extreme radiant heat, and during simulated smoke-diving. In addition, the physical cooling effect of the ice-vest was measured with a thermal mannequin.

SHBG gene promoter polymorphisms in men are associated with serum sex hormone-binding globulin, androgen and androgen metabolite levels, and hip bone mineral density

Context: SHBG regulates free sex steroid levels, which in turn regulate skeletal homeostasis. Twin studies have demonstrated that genetic factors largely account for interindividual variation in SHBG levels. Glucuronidated androgen metabolites have been proposed as markers of androgenic activity. Objective: Our objective was to investigate whether polymorphisms in the SHBG gene promoter [(TAAAA)(n

Habitual Physical Activity and Vascular Aging in a Young to Middle-Age Population at Low Cardiovascular Risk.

Background and Purpose - Regular endurance exercise has been shown to reduce the age-related increase in arterial stiffness that is thought to contribute to cardiovascular risk. The aim of this study was to evaluate the influence of age and habitual physical activity on carotid artery wall thickness and stiffness in a population of young to middle-age subjects at low cardiovascular risk. Methods -

The 39-item Parkinson's disease questionnaire (PDQ-39) revisited: implications for evidence-based medicine.

Background: The 39 item Parkinson's disease questionnaire (PDQ-39) is the most widely used patient reported rating scale in Parkinson's disease. However, several fundamental measurement assumptions necessary for confident use and interpretation of the eight PDQ-39 scales have not been fully addressed. Methods: Postal survey PDQ-39 data from 202 people with Parkinson's disease (54% men; mean age 70

Våp eller nucka? Kvinnors högre studier och genusdiskursen 1930-1970

Popular Abstract in Swedish Det har varit långt ifrån självklart att kvinnor ska få ägna sig åt högre studier. För hundra år sedan kom t ex medicinska undersökningar som ”visade” att kvinnor som studerade riskerade att bli sterila. I denna bok undersöker Lina Carls hur kvinnors högre studier 1930-1970 beskrivits i samhällsdebatten och i de lokala diskussionerna vid universiteten i Lund och UppsalaThis dissertation’s overall purpose has been to achieve an increased understanding of why women’s integration into universities has progressed so slowly. Through the analysis of the debates on women in higher education I have wanted to see if the main figures reproduce or contradict the discourse. I have had the aim of not only to show how the genus discourse was possibly repeated but also how in

HIV-2 infection in Guinea-Bissau, West Africa, with special reference to clinical, immunological and epidemiological aspects

Popular Abstract in Swedish HIV-2 isolerades första gången 1986, fem år efter att de första fallen av AIDS (orsakade av HIV-1) hade upptäckts i USA. Undersökningar har visat att HIV-2-infekterade individer också kan utveckla AIDS på samma sätt som HIV-1-infekterade personer, men smittsamheten är lägre och inkubationstiden från smitta till symtom förefaller vara längre för HIV-2 jämfört med HIV-1. We have followed a cohort of police officers in Guinea-Bissau between 1990 and 1997 for the study of clinical, immunological and epidemiological aspects of HIV-2 infection. Initially the prevalence of HIV-2 was high (11.6 %) and HIV-1 infection was rare (0.4 %), but over the study period the prevalence of HIV-1 increased significantly whereas the incidence of HIV-1 was relatively stable. For HIV-2

Political Turning Points: Rhetorical Analyses of Japanese Inauguration Speeches

After centuries of feudalism, the establishment of the Japanese parliament (the Diet) in 1890 marked a major turning point in Japanese history. Before 1890, politics as a subject of discussion was confined, more or less, to peer groups in Japanese society. In addition, at certain periods, movements promoting the spread of ideas were strictly controlled or even prohibited. Then came the new Diet,

Unified Sediment Transport Formulation for Coastal Inlet Application

The Coastal Inlets Research Program (CIRP) is developing predictive numerical models for simulating the waves, currents, sediment transport, and morphology change at and around coastal inlets. Water motion at a coastal inlet is a combination of quasi-steady currents such as river flow, tidal current, wind-generated current, and seiching, and of oscillatory flows generated by surface waves. Waves c

Understandings of understanding: An inquiry concerning experiential conditions for developmental learning

This thesis is about understandings of understanding and has developed from previous research on study skill and conceptions of learning among participants in various forms of education. The purpose was to investigate understandings of understanding as a phenomenon and the significance of understanding of understanding for learning. The investigation involved 101 persons between 12 and 75 years of

Noninvasive Monitoring of Subsurface Soil Conditions to Evaluate the Efficacy of Mole Drain in Heavy Clay Soils

Soil degradation and low productivity are among the major agricultural problems facing farmers of the newly reclaimed agricultural area in the Nile Delta region, Egypt. High content of clay and silt characterizes the soil texture of all farms in the area, while farmers still rely on the traditional mole drainage (MD) system to reduce the salinity of the farm soil. We present a comparison of innova

Exposure to local, source-specific ambient air pollution during pregnancy and autism in children : a cohort study from southern Sweden

Evidence of air pollution exposure, namely, ambient particulate matter (PM), during pregnancy and an increased risk of autism in children is growing; however, the unique PM sources that contribute to this association are currently unknown. The aim of the present study was to investigate local, source-specific ambient PM exposure during pregnancy and its associations with childhood autism, specific

Essays in Political Economy and Economic Sociology

This thesis consists of four self-contained papers within political economy and economic sociology. The first paper studies how the 2015 refugee wave impacted the vote share of the anti-immigration Sweden Democrats (SD) during the 2018 Swedish parliamentary elections. I find that while there is an overall positive effect of immigration on the SD votes, the magnitude of the effect differs considera