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Objective. To undertake a renewed analysis of data from the previously published Swedish randomized controlled trial on intrapartum fetal monitoring with cardiotocography (CTG-only) vs. CTG plus ST analysis of fetal electrocardiogram (CTG+ST), using current standards of intention-to-treat (ITT) analysis and to compare the results with those of the modified ITT (mITT) and per protocol analyses. Met

A new EU directive on used vehicles has recently been introduced. It demands that for every scrapped car, at least 85% by weight must be recycled by the year 2006 and 95% by 2015. Today this level is about 80%. The growing car disassembly industry was chosen as the study object of this thesis. Due to the increased demands on recycling, the disassembly industry is expected to undergo comprehensive

OBJECTIVES: To determine whether endometrial volume or power Doppler indices as measured by three-dimensional (3D) ultrasound imaging can discriminate between benign and malignant endometrium, to compare their diagnostic performance with that of endometrial thickness measurement using two-dimensional (2D) ultrasound examination, and to determine whether power Doppler indices add any diagnostic inf

BACKGROUND: Healthcare today is a complex system with increasing needs of specific knowledge of evaluation of research and implementation into clinical practice. A critical issue is that we all apply evidence-based practice (EBP) with standardised methods and continuing and systematic improvements. EBP includes both scientific and critical assessed experience-based knowledge. For the individual,

Large increases in regional cerebral blood flow (rCBF) have been measured in patients with Parkinson's disease (PD) following the administration of L-DOPA, but the underlying mechanisms have remained unknown. In this study, we have used rats with unilateral 6-hydroxydopamine (6-OHDA) lesions as a model of PD in order to compare the patterns of rCBF and regional cerebral glucose utilisation (rCGU)

Objectives: The effects of chronic cobalt exposure were studied in an isolated working model in a modified Langendorff preparation. Methods: Thirty-six rats were given either a conventional (control group) or a cobalt supplemented diet (cobalt group; 40 mg CoSO4 x 7 H2O/kg body weight/day). Sixteen of the animals were sacrificed and their hearts were excised after 16 weeks and the remaining 20 aft

BACKGROUND: Diffuse traumatic axonal injury (TAI), a common consequence of traumatic brain injury, is associated with high morbidity and mortality. Inflammatory processes may play an important role in the pathophysiology of TAI. In the central fluid percussion injury (cFPI) TAI model in mice, the neuroinflammatory and astroglial response and behavioral changes are unknown.METHODS: Twenty cFPI-inju

AIM: The purpose of the present study was to investigate the radiosensitivity of the prostate cancer cell lines LNCaP, DU145, and PC3 when irradiated with beta particles emitted from (177)Lu, and to compare the effect with irradiation using alpha particles or gamma rays.MATERIALS AND METHODS: Cells were irradiated with beta particles emitted from (177)Lu, alpha particles from (241)Am, or gamma ray

PURPOSE: Mutations of PCDH15, the gene encoding protocadherin 15, cause either nonsyndromic deafness DFNB23 or Usher syndrome type 1F (USH1F) in humans and deafness with balance problems in Ames waltzer (av) mice. Persons with USH1 usually begin to exhibit signs of retinitis pigmentosa (RP) in early adolescence, but av mice are reported to have functional retinas. In this study, the auditory, visu

The overall aim of this thesis is to gain a clearer picture of the differences in mobility among the young-old living in Sweden’s large metropolitan regions. This thesis comprises four papers. Paper I explores the inclusion of public transport as an element of mobility among the young-old living in the Stockholm region. Paper II presents an analysis of cycling among older people in the city of Mal

Concerns regarding environmental issues have led to increasing efforts for investigating sustainable production routes for the future industry that is based on renewable resources. Among the biobased chemicals, the C3-chemicals 3-hydroxypropionaldehyde (3-HPA), 1,3-propanediol (1,3-PDO) and 3-hydroxypropionic acid (3-HP), have been identified as top candidates for the chemical industry. Lactobacil

Objective: Patient-provider relationships with primary care and need for hospitalisations are related within the complex networks comprising healthcare. Our objective was to analyse mean days hospitalised, using registration status (active or passive listing) with a provider and number of consultations as proxies of patient-provider relationships with primary care, adjusting for morbidity burden,

AbstractAnkylosing spondylitis (AS) and undifferentiated spondyloarthritis (USpA) are two subgroups of the rheumatic disease spondyloarthritis (SpA). The diseases typically debut in early adulthood with periods of fluctuating and persistent pain and stiffness, and can result in consequences such as impaired functioning and reduced quality of life. SpA is a heterogenous group but AS and USpA share

Background: Persistent organic pollutants (POPs) have been associated with type 2 diabetes (T2D), but causality is uncertain. Objective: Within longitudinal population-based data from northern Sweden, we assessed how POPs associated with T2D prospectively and cross-sectionally, and further investigated factors related to individual changes in POP concentrations. Methods: For 129 case-controls pair

The Genographic Project is an international effort aimed at charting human migratory history. The project is nonprofit and nonmedical, and, through its Legacy Fund, supports locally led efforts to preserve indigenous and traditional cultures. Although the first phase of the project was focused on uniparentally inherited markers on the Y-chromosome and mitochondrial DNA (mtDNA), the current phase f

Obesity is a well-established risk factor for colorectal cancer (CRC), but the association with the tumor microenvironment has been sparsely described. Herein, we examined the relationship between pre-diagnostic anthropometry and CRC risk according to tumor immune cell composition, with particular reference to potential sex differences. The density of different immune cell subsets was assessed by

Germline mutations of BRCA1 and BRCA2 predispose individuals to a high risk of breast and ovarian cancer, and elevated risk of other cancers, including those of the pancreas and prostate. BRCA2 mutation carriers may have increased risk of uveal melanoma (UM) and cutaneous melanoma (CM), but associations with these cancers in BRCA1 mutation carriers have been mixed. Here, we further assessed whethe

Hemicelluloses are a group of abundant polymers found in all plants and constitute about one third of the total plant biomass. These polymers can be used in many different products, such as oxygen barrier films, emulsifiers, foams and probiotic food additives. However, the commercial development and use of new products utilizing hemicelluloses has been limited due to the high production cost. Incr

Tau is an axonal microtubule-binding protein. Tau pathology in brain and increased tau concentration in the cerebrospinal fluid (CSF) are hallmarks of Alzheimer’s disease (AD). Most of tau in CSF is present as fragments. We immunoprecipitated tau from CSF and identified several endogenous peptides ending at amino acid (aa) 123 or 224 using high-resolution mass spectrometry. We raised neo-epitope-s

BACKGROUND: Arsenic exposure affects [Formula: see text] people worldwide, including [Formula: see text] in Bangladesh. Arsenic exposure increases the risk of cancer and other chronic diseases, and one potential mechanism of arsenic toxicity is epigenetic dysregulation. OBJECTIVE: We assessed associations between arsenic exposure and genome-wide DNA methylation measured at baseline among 396 Bangl