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Physical Activity, Bone Mass and Bone Structure in Pre-pubertal Children

Low bone mineral density (BMD) is a risk factor for fractures and much of the fracture preventive effort today is devoted to preventing low BMD. Physical activity (PA) has been described as one of the best strategies to optimize skeletal development in the growing child. However, most exercise intervention studies in children have involved the use of volunteers and specifically designed high impac

Sertoli and Germ Cells Within Atrophic Seminiferous Tubules of Men With Non-Obstructive Azoospermia

Background: Infertile men with non-obstructive azoospermia (NOA) have impaired spermatogenesis. Dilated and un-dilated atrophic seminiferous tubules are often present in the testes of these patients, with the highest likelihood of active spermatogenesis in the dilated tubules. Little is known about the un-dilated tubules, which in NOA patients constitute the majority. To advance therapeutic strate

Adipose methylome integrative-omic analyses reveal genetic and dietary metabolic health drivers and insulin resistance classifiers

Background: There is considerable evidence for the importance of the DNA methylome in metabolic health, for example, a robust methylation signature has been associated with body mass index (BMI). However, visceral fat (VF) mass accumulation is a greater risk factor for metabolic disease than BMI alone. In this study, we dissect the subcutaneous adipose tissue (SAT) methylome signature relevant to

Effectiveness of traditional chinese exercise for symptoms of knee osteoarthritis : A systematic review and meta-analysis of randomized controlled trials

Background: Growing evidences have advocated the potential benefits of traditional Chinese exercise (TCE) on symptomatic improvement of knee osteoarthritis (KOA). However, most of them have been derived from cross-sectional studies or case reports; the effectiveness of TCE therapies has not been fully assessed with a randomized control trial (RCT). In order to evaluate the combined clinical effect

Cohort study of prediction of venous thromboembolism in emergency department patients with extremity symptoms

Despite diagnostic algorithms, identification of venous thromboembolism (VTE) in emergency departments (ED) remains a challenge. We evaluated symptoms, background, and laboratory data in 27,647 ED patients presenting with pain, swelling, or other symptoms from the extremities, and identified predictors of VTE diagnosis within one year. Predictors of a clinical decision to perform phlebography, ult

First dose of misoprostol administration at home or in hospital for medical abortion between 12–22 gestational weeks in Sweden (PRIMA) : a multicentre, open-label, randomised controlled trial

Background: Medical abortion after 12 gestational weeks often requires a stay in hospital. We hypothesised that administering the first misoprostol dose at home could increase day-care procedures as compared with overnight care procedures, shorten inpatient stays, and improve patient satisfaction. Methods: This multicentre, open-label, randomised controlled trial was done at six hospitals in Swede

Endothelial Cell pY397-FAK Expression Predicts the Risk of Breast Cancer Recurrences after Radiotherapy in the SweBCG91-RT Cohort

Purpose: Identifying biomarkers of radiotherapy (RT) response is important for optimizing the treatment of early breast cancer. In this study, we tested the interaction between endothelial cell (EC) expression of phospho-Tyr397-FAK (pY397-FAK) and adjuvant-RT on clinical outcomes after breast-conserving surgery (BCS) within a randomized study. Preclinical data suggest an enhanced effect of RT on l

MRI only radiotherapy using synthetic CT images: Dosimetric accuracy and patient positioning strategies in an MRI only workflow

Sedan sent 1800-tal har strålterapi använts för behandling av cancer. 50% av alla cancerpatienter blir någon gång behandlade med strålterapi, som är en avancerad teknik med många olika steg för att uppnå den slutgiltiga behandlingsplanen. Patienten börjar sin strålbehandlingsresa med att bli diagnosticerad och får sin behandling ordinerad. Efter detta startar förberedelserna inför strålbehandlingeBackground and purpose: Magnetic resonance imaging (MRI) only radiotherapy has, due to superior soft tissue contrast of MRI and the possible reduction of systematic uncertainties, grown into a promising technique. The purpose of this work is to investigate parts of an MRI only workflow with synthetic computed tomography (sCT) images generated from MRI. This was done through investigation of treatm

Using geographical information systems in epidemiology : mapping & analyzing occurrence of diarrhea in urban–residential area of Islamabad, Pakistan

Almost 2 million people are living in Islamabad, significant number of workforce commute from neighboring areas and other parts of the country. The city is facing restraint on natural resources due to increased urban migration coupled with rapid population growth. As a result, the city infrastructure facilities and living conditions are deteriorating. The problems associated with drinking water av

Praktiskt förändringsarbete – Fallstudie på en liten mekanisk verkstad

Syfte: Syftet med förändringsarbetet är att hjälpa Varberger Sweden AB att skapa den fungerande produktionsapparat som behövs för att jobba enligt den av företaget utarbetade affärsidén med kärnkompetens och kundanpassning. Arbetet kommer att beskriva det använda arbetssättet, dvs. analysarbetet, men huvudsyftet är att skapa förändringar i företaget och så långt som möjligt implementera dessa. PrPurpose: The purpose with the work of change was to help the company Varberger Sweden AB to change its way of working and by that enabling the company to reach the developed business concept were core competences such as precision and customization was seen as the key to success. Task description: The company Varberger Sweden AB have for different reasons gone into bankruptcy some times during th

Internal benchmark of IKEA's Sourcing Assignment processes and documents across business areas and categories - A multiple case study

Background: The IKEA Range & Supply organisation consists of business areas (BAs) and categories. BAs work with product development toward end-customers while the material-based categories work toward suppliers with purchasing and sourcing related tasks. There exists an internal cross-organisational interface between these units and IKEA recently created Sourcing Assignment as a tool to encour

Modeling Slovenian Forests under climate change and future management

Forests’ high importance due to the ecosystem services they supply is undisputed. The mitigation of climate change through net uptake of carbon dioxide from the atmosphere (carbon sinks) is one of them and the biodiversity hosted by a forest is an important underpinning of its functioning and may help promote the resilience of forest ecosystem services to future change. Uneven-aged forests general

Evaluating the suitability of carbon source from fermentation of primary filter sludge for biological nutrient removal

Traditionell biologisk näringsavskiljning inom avloppsvattenrening, såsom denitrifikation och biologisk fosforavskiljning (EBPR), kräver tillgång på lättnedbrytbart kol för att bra reningsgrad ska uppnås. Dock är en stor andel av kolet i det inkommande avloppsvattnet partikulärt och måste hydrolyseras innan det blir tillgängligt för bakterierna i den biologiska reningen. Flera studier har studeratTraditional biological nutrient removal (BNR) processes in wastewater treatment require access to easily biodegradable carbon in order to achieve sufficient removal. However, a lot of the carbon in the influent wastewater is not directly available for BNR bacteria but need to undergo hydrolysis first. Several studies have investigated the possibility to produce an internal carbon source from the g

Klimatsmart betongbyggande

Ett av Sveriges hållbarhetsmål är att senast 2045 inte generera några nettoutsläpp av växthusgaser. För att uppnå detta mål krävs kraftiga åtgärder inom alla sektorer. En av dessa är bygg- och fastighetssektorn som 2018 stod för ca 22 % av Sveriges territoriella utsläpp av växthusgaser. Enbart cementindustrin står för ca 5–7 %. Cirka hälften av klimatpåverkan från moderna flerbostadshus uppkommer One of the main sustainability goals in Sweden is to reduce the nations greenhouse gas emissions to a net-zero level by 2045. This is a national implementation of the Paris- Agreement. To achieve this goal measures need to be taken in all industrial sectors. The construction and real-estate sectors are responsible for about 22 % of Sweden’s yearly territorial greenhouse gas emissions. The cement i

Klimatsmart betongbyggande

Ett av Sveriges hållbarhetsmål är att senast 2045 inte generera några nettoutsläpp av växthusgaser. För att uppnå detta mål krävs kraftiga åtgärder inom alla sektorer. En av dessa är bygg- och fastighetssektorn som 2018 stod för ca 22 % av Sveriges territoriella utsläpp av växthusgaser. Enbart cementindustrin står för ca 5–7 %. Cirka hälften av klimatpåverkan från moderna flerbostadshus uppkommer One of the main sustainability goals in Sweden is to reduce the nations greenhouse gas emissions to a net-zero level by 2045. This is a national implementation of the Paris- Agreement. To achieve this goal measures need to be taken in all industrial sectors. The construction and real-estate sectors are responsible for about 22 % of Sweden’s yearly territorial greenhouse gas emissions. The cement i

To Protect Lives or Personal Data?

The adoption of the General Data Protection Regulation proclaimed Europe’s stance on the significance of the right to data privacy today whereas digital technologies have prevailed all around the globe and all spheres of our lives. Digitalization is thus a phenomenon that has ever since drawn attention from leaders and policymakers which why the Regulation along with other European privacy regimes

Lagen om penningtvätt - lätt att tillämpa rätt?

Examensarbetets titel: Lagen om penningtvätt - lätt att tillämpa rätt? En kvalitativ studie om revisorers tillämpning av lagen om åtgärder mot penningtvätt och finansiering av terrorism. Seminariedatum: 17:e januari 2020 Ämne/kurs: FEKH69, Examensarbete i redovisning på kandidatnivå, 15 högskolepoäng Författare: Green, L., Jakobsson, L. & Liljenborg, J. Handledare: Karin Jonnergård FeTitle: Auditors application of the Money Laundering Act - a qualitative study about auditors’ application of The Money Laundering and Terrorist Financing (Prevention) Act. Seminar date: 17th of January 2020 Course: FEKH69, Bachelor’s Degree Project in Financial and Management Accounting, Undergraduate level, 15 University Credits Points Authors: Green, L., Jakobsson, L. & Liljenborg, J.

Utredning av möjligheterna till marin förnybar energi i Öresund

Syftet med denna studie är att utreda möjligheterna för Öresundskraft AB att utvinna marin förnyelsebar energi från norra Öresund. Studien genomförs i två delar där Öresunds fysikaliska egenskaper samt marina krafttekniker kartläggs i den första för att sedan analysera den möjliga miljöpåverkan från de alternativen som kan vara intressanta i Öresund. De marina energitekniker som studerades var OTEThe purpose of this study is to determine the possibilities for Öresundskraft AB to derive marine renewable energy from northern Öresund, the sound between Sweden and Denmark. The physical properties of the sound, such as temperature, current speed, wave height, salinity gradients, bathymetry, are researched as well as which technologies are present in the current marine renewable energy market. T

Grönt byggande - anläggningsbranschen

Building in a manner that minimizes environmental impact has become a major part of the construction industry. Despite increased knowledge in this area the development is moving slowly. The purpose of this thesis is to give the reader an idea of the approach to green construction of civil engineering. The definition of a green tender is defined by the people who have been interviewed. The question

Modelling near ground wind speed in urban environments using high-resolution digital surface models and statistical methods

Populärvetenskaplig sammanfattning Den ökande urbaniseringen värden över och de hälsorisker som identifierats i samband med värmeböljor i städer, har medfört att det urbana klimatet blivit ett allt viktigare forskningsområde. Vindhastighet är en av de viktigaste parametrarna när det gäller att beräkna lokala klimatvariationer och bedöma eventuella hälsorisker. En enkel beräkningsmetod för vind kanWind is a complex phenomenon and a critical factor in assessing climatic conditions and pedestrian comfort within cities. This master’s thesis attempts to quantify and model the relationship between near ground wind speed and urban geometry using two-dimensional raster data and variable selection methods based on Multiple Linear Regression. A simple regression model can be implemented in a Geogra