Filetype
Several metal complex agents have already been introduced into clinical tumor therapy and others are subject of antitumor studies. In this study we focused on the tetraaza macrocyclic copper complex (Cu(TAAB)Cl-2). We studied the influence of the substance on cell growth, cell cycle, membrane integrity, necrosis, apotosis and glutathione level on the leukemic cell line L1210 in 1-day (22 h) and 3-
Objectives: To review case histories of patients in whom fibrosis played a significant role in the pathogenesis of their disease, and to determine whether intravenous gammaglobulin (IVIg) contributed to the regression of their fibrotic condition. Methods: Eight patients with excess fibrotic reaction in the course of diverse diseases were analysed; a tendency that reverted with different IVIg treat
Background: Cellular interactions elicited by Plasmodium falciparum erythrocyte membrane protein antigen 1 (PfEMP1) are brought about by multiple DBL ( Duffy binding like), CIDR ( cysteine-rich interdomain region) and C2 domain types. Elucidation of the functional and structural characteristics of these domains is contingent on the abundant availability of recombinant protein in a soluble form. A
This paper presents a new relationship between the roughness height and the main hydrodynamic and sediment parameters for plane beds under steady current conditions. In order to derive such a formula, a large data base involving plane-bed experiments was compiled from previous investigations and analyzed. Comparisons between the data and different existing predictive formulas for the bed roughness
Objective: To assess the effects of a 6-month angiotensin-converting enzyme (ACE) inhibitor intervention on myocardial ischaemia.Method: We randomized 389 patients with stable coronary artery disease to double-blind treatment with ramipril 5 mg/day (n = 133), ramipril 1.25 mg/day (n = 133), or placebo (n = 123). Forty-eight-hour ambulatory electrocardiography was performed at baseline, and after 1
In stroke patients several cardiac changes associated with embolism can be detected with transoesophageal echocardiography. Potential major cardiac embolic sources (e.g. atrial fibrillation, thrombi of left ventricle/atrium, vegetation, myxoma, dilated cardiomyopathy) have a causal relationship to embolism. Other changes with no certain causal relationship are regarded as potential minor cardiac e
This bachelor’s thesis in statistics explores frequentist and bayesian methods for parameter estimation and compares their usefulness when applied to opinion polls of party sympathies in the Swedish political system. Through simulation in R, random samples are generated from a population modelled after the Swedish electorate at various points during the 2010s and 2020s. The party for which each in
The aim of this study was to examine how social workers working with the Staircase Model and Housing First can help long-term homeless people with a long history of alcohol and/or drug abuse, their view of the models and how they describe and use their discretion. I used a qualitative method and data was gathered by semi-structured interviews. I interviewed five social workers in four different mu
Flows of energy between the atmosphere, the oceans and the land surfaces drive weather and climate on Earth. Increased understanding of these processes is crucial to successfully predict and address the challenges of climate change. Land surface models (LSM) are mathematical models designed to mimic natural processes and evolution of land surfaces with the basic task to simulate surface-atmosphere
The primary purpose of this thesis is to assess policy measures promoting the uptake and use of low-carbon technologies in urban road freight transport (URFT) in Oslo, Norway. This sector has historically received little attention compared to passenger and public transport, but contribute to significant greenhouse gas (GHG) emissions, noise, and other negative health effects. Low-carbon vehicles i
The genes being studied here are plant Flavin-containing monooxygenase (FMO’s) which are enzymes that place molecular oxygen on heteroatoms such as nitrogen, and sulfur with the help of cofactors such as NAD(P)H and FAD. Plant FMOs are divided into three major clades: N-hydroxylating, S-hydroxylating and YUCCA. The YUCCA family is conserved in all plants, and performs oxidative decarboxylation of
Dagens Nyheter etablerade under våren 2022 lokala redaktioner i Luleå och Umeå med syftet att förmedla nyhetshändelser från Norrland till en rikspublik. Sedan uppstarten i mars 2022 till tidpunkten för genomförandet av denna studie har runt 180 artiklar producerats av redaktionens reportrar. Syftet med studien är att undersöka hur Norrland representeras och gestaltas i Dagens Nyheter och ifall etaDuring the spring of 2022, the Stockholm-based newspaper Dagens Nyheter established two newsrooms in the cities Luleå and Umeå located in the north of Sweden. The purpose was to communicate news events from Norrland to a national audience. From the start of the newsrooms until the time of this study, around 180 articles were published. The aim of this study is to investigate how the region of Nor
Bakgrund: Årligen diagnostiseras över 6900 personer i bröstcancer och utgör den vanligast förekommande dödsorsaken hos kvinnor. Möjligheten att upptäcka sjukdomen i ett tidigt skede har ökat i Sverige då kvinnor i åldrarna 40-74 erbjuds hälsokontroller med mammografiscreening. Syftet med denna litteraturstudie var att beskriva kvinnors upplevelser av mammografiscreening. Metod: En litteraturstudieIntroduction: Breast cancer is the most common death cause among women, more than 6900 women are diagnosed every year. The opportunity to discover the disease in an early stage has increased due to all women in Sweden are offered health checks with mammography screening. The aim of this study was to examine women's experiences of mammography screening. Method: The study was conducted as a lite
Rearrangements of chromosome arm 15q are rare but recurrent in conventional lipomas, a tumor type often showing deregulated expression of the HMGA2 gene. In order to assess whether 15q rearrangements could constitute a distinct pathogenetic mechanism, we studied seven cases of conventional lipoma that at G-banding analysis had various rearrangements of 15q12-q21. The breakpoints in 15q were mapped
Abstract Lymphoedema treatment outcome can be evaluated by calculating estimated limb volumes directly by water displacement (plethysmography; PG), or indirectly by circumference measurements (CM) and using the formula for a truncated cone. This study assessed the correlation between PG and circumference volume measurements to assess whether the correlation is acceptable, and if circumference meas
Clinical blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) is becoming increasingly valuable in, e.g., presurgical planning, but the commonly used gradient-echo echo-planar imaging (GE-EPI) technique is sometimes hampered by macroscopic field inhomogeneities. This can affect the degree of signal change that will occur in the GE-EPI images as a response to neural
Objective: To compare effectiveness, drug survival, and safety between infliximab, adalimumab, and etanercept, in a nationwide cohort of rheumatoid arthritis (RA) patients. Methods: This study is a prospective cohort study of 1208 active RA patients. Effectiveness, drug survival, and serious adverse events during entire follow-up (median 2.9 years) were monitored. Results: EULAR and CDAI responses
In retinal transplantation experiments it is hypothesized that remaining diseased photoreceptor cells in the host retina and inner retinal cells in transplants physically obstruct the development of graft-host neuronal contacts which are required for vision. Recently, we developed methods for the isolation of donor photoreceptor layers in vitro, and the selective removal of host photoreceptors in
Removal of five acidic pharmaceuticals (ibuprofen, ketoprofen, naproxen, diclofenac and clofibric acid) by activated sludge from five municipal activated sludge treatment processes, with various sludge ages and nitrification capacities, was assessed through batch experiments. The increase in aerobic sludge age from 1-3 to 7 d seemed to be critical for the removal of naproxen and ketoprofen, with m
