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For more than a century the research on the Antikythera Mechanism engaged scientists from a widerange of scientific disciplines searching for clues, in order to solve the mystery that this unique ar-chaeological find poses. The results so far have been spectacular enough to re-write the History ofTechnology providing new aspects on the degree of technological sophistication and scientific de-velop
Precipitation, as an important component of the Earth’s water cycle, plays a determinant role in various socio-economic practices. Consequently, having access to high-quality and reliable precipitation datasets is highly demanded. Although Gridded Precipitation Products (GPPs) have been widely employed in different applications, the lack of quantitative assessment of GPPs is a critical concern tha
Background/objectives: Alzheimer’s disease (AD) is currently diagnosed clinically using defined symptomatic diagnostic criteria. Pathological levels of CSF-biomarkers, high T-tau, P-tau and low Ab42 have been associated with AD however definition of cut off values differ. New diagnostic criteria that include the pathological CSF biomarkers have been suggested. How many AD patients in a routine cli
Dioxins and polychlorinated biphenyls (PCBs) are toxic, endocrine disruptors and persistent chemicals for which the main exposure source is diet due to their bioaccumulation and biomagnification in food chains. Cohort studies in the general populations have reported inconsistent associations between these chemicals in serum/plasma and mortality. Our objective was to study the association between d
Aims/Hypotheses: To investigate the frequency and characteristics of partial remission in Swedish children with type 1 diabetes and whether the insulin delivery method, that is, continuous subcutaneous insulin infusion (CSII) or multiple daily injections (MDIs), affects incidence and duration of this period, 2007-2011. Factors that increase the proportion of subjects who enter partial remission an
In this licentiate thesis the implications of a deliberate use of logistics knowledge have been investigated by describing and analyzing the use of a supply chain management approach in the construction industry.
A five-step approach is used in the thesis. First, theoretical models are developed from the supply chain management literature. Two models are elaborated; One model identifying sup
BACKGROUND: Several widely used drugs have photosensitizing properties, and much research has been conducted to find associations between their use and the risk of developing cutaneous malignant melanoma (cM), basal cell carcinoma (BCC) or cutaneous squamous cell carcinoma (cSCC), often with conflicting results.OBJECTIVE: To assess whether the use of commonly prescribed photosensitizing drugs incr
Background Exclusive breastfeeding is essential for infant health, yet its practice varies across generations and cultures. Although the health benefits of breastfeeding have been well known for decades, the utilization of infant formula feeding worldwide and in Oman, in particular, continues to rise, most likely as a result of a lack of social support and the time limit faced by working mothers.
Aims: Repeated risk assessments and treatment patterns over long time are sparsely studied in chronic thromboembolic pulmonary hypertension (CTEPH); thus, we aimed to investigate changes in risk status and treatment patterns in incident patients with CTEPH over a 5 year period. Methods and results: Descriptive and explorative study including 311 patients diagnosed with CTEPH 2008–2019 from the Swe
Background and Aims: Substance use disorder (SUD) is related to widespread adverse consequences, including higher suicidality. Shared genetic liability has been demonstrated between SUD and suicidality. Here, we measured the factors that contribute to increased risk of non-fatal suicide attempt among individuals with SUD by focusing upon aggregate genetic risks and both childhood and past-year env
Background Anorexia nervosa is associated with high personal and financial costs for sufferers, carers and society in general, but little is known about the long-term health economic burden. Aims To examine healthcare utilisation, social assistance, sick leave and disability pension in individuals with anorexia nervosa over a period of 30 years. Method Fifty-one individuals with adolescent-onset a
Nepal ligger i ett av världens mest jordbävningsutsatta områden, och jordbävningen i Gorkha 2015 visade tydligt hur sårbara murverksbyggnader utan ingenjörsmässig dimensionering kan vara. I återuppbyggnadsarbetet har interlocking Compressed Sta- bilised Earth Blocks (CSEB) lyfts fram som ett möjligt alternativ till traditionellt murverk av bränt lertegel. Detta eftersom systemet både kan vara mer Nepal is located in one of the most seismically active regions in the world, and the 2015 Gorkha earthquake clearly demonstrated the vulnerability of non-engineered masonry buildings. In the reconstruction efforts following the earthquake, interlocking Com- pressed Stabilised Earth Blocks (CSEB) have been highlighted as a potentially more seismically robust and at the same time more sustainable al
AIM: Preoperative anaemia is a well-established risk factor for poor outcomes. However, the impact of postoperative haemoglobin (Hb) levels on long-term outcomes, including mortality and cardiovascular events, remains uncertain. This study aims to assess the independent association between postoperative nadir Hb levels and long-term outcomes, considering the potential interaction with preoperative
Objective:To compare the diagnostic accuracy of CSF biomarkers and amyloid PET for diagnosing early-stage Alzheimer disease (AD).Methods:From the prospective, longitudinal BioFINDER study, we included 122 healthy elderly and 34 patients with mild cognitive impairment who developed AD dementia within 3 years (MCI-AD). -Amyloid (A) deposition in 9 brain regions was examined with [F-18]-flutemetamol
The purpose of this thesis is to explore the prevalence of sexually offending behaviour among female and male adolescents in Sweden. One aim is to identify potential risk factors associated with sexually offending behaviour and a further aim to examine the outcome in early adulthood for a sample of sexually offending adolescent males. Three different samples were used for this thesis. A sample of
Background: Musculoskeletal disorders (MSDs) are a major reason for impaired work productivity and sick leave. In 2009, a national rehabilitation program was introduced in Sweden to promote work ability, and patients with MSDs were offered multimodal rehabilitation. The aim of this study was to analyse the effect of this program on health related quality of life, function, sick leave and work abil
Background: Hitherto, risk prediction models for preoperative ultrasound-based diagnosis of ovarian tumors were dichotomous (benign versus malignant). We develop and validate polytomous models (models that predict more than two events) to diagnose ovarian tumors as benign, borderline, primary invasive or metastatic invasive. The main focus is on how different types of models perform and compare. M
Hematopoietic stem cells (HSC) are multipotent and possess self-renewal capacity. Thus, they can sustain a life-long hematopoiesis and are also capable of restoring the hematopoietic system when transplanted to a patient. In allogeneic hematopoietic stem cell transplantation (HSCT), a potent graft-versus-leukemia (GvL) effect must be balanced against the concomitant risk of severe immunological re
1 Plant species differ in their capacity to influence soil organic matter, soil nutrient availability and the composition of soil microbial communities. Their influences on soil properties result in net positive or negative feedback effects, which influence plant performance and plant community composition. 2 For two grassland systems, one on a sandy soil in the Netherlands and one on a chalk soi
