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Increasing credibility in government assignments : an example from Sweden of stakeholder involvement by using Concept Mapping

Background The incidence of people diagnosed with cancer is increasing worldwide, in Sweden with approximately 65 000 new cases yearly. To enhance conditions for a continued good life, high-quality, accessible and equal cancer rehabilitation is required. In 2020 the National Board of Health and Welfare (NBHW) received a government assignment to investigate the conditions for the offer of cancer re

Metabolic syndrome in childhood, adolescent, and young adult cancer survivors: recommendations for surveillance from the International Late Effects of Childhood Cancer Guideline Harmonization Group

Objective: Survivors of childhood, adolescent, and young adult (CAYA) cancer have an increased risk of metabolic syndrome (MetS). MetS describes the clustering of cardiovascular risk factors including overweight or obesity, hypertension, (pre)diabetes, and dyslipidaemia. While associated cardiovascular sequelae can be serious, MetS is preventable, manageable, and potentially reversible with the ap

Responses to multiple-nutrient starvation in marine Vibrio sp. strain CCUG 15956

The response of marine Vibrio sp. strain S14 (CCUG 15956) to long-term (48-h) multiple-nutrient starvation (i.e., starvation for glucose, amino acids, ammonium, and phosphate simultaneously) can be described as a three-phase process. The first phase, defined as the stringent control phase, encompasses an accumulation of guanosine 5'-diphosphate 3'-diphosphate (ppGpp) and decreases in RNA and prote

Thermal reactivity and fire risk in lagging systems : Influence of contaminants, lagging materials, and metals

Lagging fires pose a significant safety risk in industrial systems where organic contaminants interact with lagging (insulation) materials. This study used isothermal calorimetry to investigate factors influencing the self-heating and ignition propensity of various C18-based substances and rapeseed oil, as contaminants in the lagging. The contaminant and lagging under investigation were added to g

Connectedness to colleagues when working from home: insights into the global experience

PurposeThis study aims to determine whether employees are satisfied with their connection to colleagues when working from home (WFH), whether their satisfaction is influenced by sociodemographic factors and home-based work settings and whether cross-country differences exist.Design/methodology/approachUsing survey data from 137,487 knowledge workers across 88 countries, collected during a real-wor

Apalutamide in Patients with High Burden of Metastatic Hormone-sensitive Prostate Cancer : A Subgroup Analysis of TITAN

BACKGROUND AND OBJECTIVE: A post hoc analysis of TITAN evaluated the clinical benefit of apalutamide plus androgen-deprivation therapy (ADT) versus ADT alone in metastatic hormone-sensitive prostate cancer (mHSPC) with high disease burden. METHODS: Patients were assessed in subgroups of those with four to fewer than ten, ten to <20, or ≥20 bone metastases; with lung but not liver metastases; and w

Islamic educational spaces : architecture of Madrasah and Muslim educational institutions

The mosque (both as masjid or jāmiʿ) is recognized as the first Muslim educational space for formal and informal learnings, for children and adults alike. Although the mosque remained as one of the primary centers of Islamic studies in various disciplines to this day, the Muslim cities from the Middle Ages onward have witnessed the emergence of specific institutions for Islamic education. Kuttābs

Becoming a midwife – A phenomenographic study of students' conceptions of learning within a midwifery continuity of care experience project

Background: Midwifery continuity of care (MCoC) is a key aspect of woman-centred midwifery care, associated with improved outcomes for both women and midwives. In many countries, maternity care is fragmented, and MCoC uncommon in clinical practice and midwifery education. To address this gap, a pedagogical project entitled “Midwifery Student All the Way” was introduced in a midwifery programme in

Evaluation of a Particle Enhanced Turbidimetric Immunoassay (PETIA) for detecting calprotectin in sputum samples

BackgroundChronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF) are characterized by persistent airway inflammation and airflow limitation. Measuring airway inflammation may be of value both in research and clinical practice. Calprotectin, a protein associated with neutrophil activation, serves as a potential biomarker for airway inflammation. This study evaluates the performance o

Clinical-pathological features in placentas of pregnancies with SARS-CoV-2 infection and adverse outcome : case-series with and without congenital transmission

Objective: To correlate clinical outcomes to pathology in SARS-CoV-2 infected placentas in stillborn and liveborn infants presenting with foetal distress.Design: Retrospective, observational.Setting: Nationwide.Population or sample: Five stillborn and 9 liveborn infants from 13 pregnant women infected with SARS-CoV-2 seeking care at 7 different maternity units in Sweden.Methods: Clinical outcomes

Impaired artery elasticity predicts cardiovascular morbidity and mortality- A longitudinal study in the Vara-Skövde Cohort

It is still debated whether arterial elasticity provides prognostic information for cardiovascular risk beyond blood pressure measurements in a healthy population. To investigate the association between arterial elasticity obtained by radial artery pulse wave analysis and risk for cardiovascular diseases (CVD) in men and women. In 2002–2005, 2362 individuals (men=1186, 50.2%) not taking antihypert

Experimental Testing and Numerical Evaluation of the Strain-softening Behavior of Birch Using a Cross-validation Calibration Approach

Softwood species are the most commonly used species in structural applications in north-ern Europe. However, in the last couple of years, utilization of hardwoods has gatheredincreased momentum, and different hardwood species, such as birch, have even been uti-lized in cross laminated timber and glued laminated timber [1]. In general hardwoodsshow an increase in strength and stiffness as compared

The role of substance use disorders in the transition from suicide attempt to suicide death : a record linkage study of a Swedish cohort

BACKGROUND: Suicidal behavior and substance use disorders (SUDs) are important public health concerns. Prior suicide attempts and SUDs are two of the most consistent predictors of suicide death, and clarifying the role of SUDs in the transition from suicide attempt to suicide death could inform prevention efforts. METHODS: We used national Swedish registry data to identify individuals born 1960-19

Sensitization to molecular dog allergens in an adult population : Results from the West Sweden Asthma Study

Background: As the prevalence of dog allergy rises, component resolved diagnosis might improve the diagnosis, understanding of the clinical outcomes and the effectiveness of immunotherapy. Considering the paucity of data in adults, the current study characterized the patterns of sensitization to dog molecular allergens in an adult population. Methods: Data were derived from the West Sweden Asthma

Identifying older adults at increased risk of medication-related hospital readmission

IntroductionPrevious studies show that approximately 40% of hospital readmissions in older adults are medication-related and that about 70% of these could be prevented. A risk assessment tool aiming to identify older adults at increased risk of medication-related readmission could help maximize the impact of implemented preventive measures and save healthcare resources. In this study we made furth

Multi-Modal in Vitro Experiments Mimicking the Flow Through a Mitral Heart Valve Phantom

Purpose: Fluid-structure interaction (FSI) models are more commonly applied in medical research as computational power is increasing. However, understanding the accuracy of FSI models is crucial, especially in the context of heart valve disease in patient-specific models. Therefore, this study aimed to create a multi-modal benchmarking data set for cardiac-inspired FSI models, based on clinically

Digital self-management, analgesic use and patient-reported outcomes in knee or hip osteoarthritis

ObjectiveTo investigate changes in analgesic use before and after participation in a digital first-line treatment program (exercise and patient education) in persons with knee or hip OA and to explore associations between these changes in medication use and participant-reported pain and function.DesignRetrospective cohort study with pre-post measures.SettingCommunity setting, Sweden.ParticipantsIn

The Gestalt of functioning in autism revisited : First revision of the International Classification of Functioning, Disability and Health Core Sets

Functioning is a construct capturing how an individual’s engagement in everyday life emerges from the interaction between the individual and their environment. The World Health Organization’s International Classification of Functioning, Disability and Health (ICF) provides a biopsychosocial framework of functioning. Previously, the ICF was adapted for use in autism by developing Core Sets, a selec

A novel quinoline with airway relaxant effects and anti-inflammatory properties

Background: In chronic pulmonary diseases characterized by inflammation and airway obstruction, such as asthma and COPD, there are unmet needs for improved treatment. Quinolines is a group of small heterocyclic compounds that have a broad range of pharmacological properties. Here, we investigated the airway relaxant and anti-inflammatory properties of a novel quinoline (RCD405). Methods: The airwa

A population-based study of the appearances of enteric Campylobacter and non-typhoidal Salmonella infections on computed tomography

BackgroundSwift identification and diagnosis of gastrointestinal infections are crucial for prompt treatment, prevention of complications, and reduction of the risk of hospital transmission. The radiological appearance on computed tomography could potentially provide important clues to the etiology of gastrointestinal infections. We aimed to describe features based on computed tomography of patien