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AIM: The aim of this study was to evaluate wound healing, major amputation and mortality in patients with diabetic foot ulcer and peripheral arterial disease (PAD), and to compare the group decided to have an endovascular intervention with groups referred to conservative treatment or to those judged as unreconstructable. METHODS: A retrospective two-year review of all patients with diabetic foot
BACKGROUND Surgical site infections (SSIs) after dermatologic surgery cause pain, prolong healing, result in unaesthetic complications, and lead to excessive use of antibiotics. The pathogenesis of wound infections is complex and is dependent on bacterial load and diversity, among several factors. OBJECTIVE To investigate bacterial dynamics at dermatosurgical sites at different time intervals and
Purpose/Aim: To explore changes in morphology and function in the rabbit retina after intravitreal high-dose injection of three commonly used VEGF inhibitors. Materials and methods: Forty-eight rabbits of mixed strain (6 months of age, body weight ≈ 3 kg) were randomized into four groups (n = 12). They were examined with full-field electroretinography (ERG) and with multifocal electroretinograph
Purpose: To demonstrate the feasibility of multidimensional diffusion MRI to probe and quantify microscopic fractional anisotropy (µFA) in human kidneys in vivo. Methods: Linear tensor encoded (LTE) and spherical tensor encoded (STE) renal diffusion MRI scans were performed in 10 healthy volunteers. Respiratory triggering and image registration were used to minimize motion artefacts during the acq
While digitalisation is a widespread technological, social and economic process, shaping markets and consumers, not all efforts to produce digitalised smart consumers are successful. The aim of this paper is to explore and explain failures in the digital agencing of consumers. Making use of the market studies literature on consumer agencing, and drawing on an ethnographic study of ethical shopping
Fashions come and go. Industrialized building (IB) is no exception, having its roots far in the past and appearing in just about every type of construction, including infrastructure, at one time or another. Industrialization, as a term applied to the production of goods, can be on a macro-scale as in the case of large assemblies and near-complete structures. But it also applies to myriad products
Purpose: Children and adolescents with primary headache are at risk of persistent somatic symptoms and reduced quality of life (Qol) due to pain and pain-related behaviors, such as avoiding school and activities. Sleep is essential to health, and children and adolescents with primary headaches have more sleep complaints than do healthy controls. A treatment approach that addresses multifactorial c
BACKGROUND AND PURPOSE: Increased CSF stroke volume through the cerebral aqueduct has been proposed as a possible indicator of positive surgical outcome in patients with idiopathic normal pressure hydrocephalus; however, consensus is lacking. In this prospective study, we aimed to compare CSF flow parameters in patients with idiopathic normal pressure hydrocephalus with those in healthy controls a
Understandability of the current system is a key issue in most reengineering processes. An architecture description of the system may increase its understandability. This paper presents experiences from architectural design recovery in a product family of large distributed, embedded systems. Automated recovery tools were hard to apply due to the nature of the source code. A qualitative evaluation
Aims: The nuclear proliferation marker Ki67 assayed by immunohistochemistry has multiple potential uses in breast cancer, but an unacceptable level of interlaboratory variability has hampered its clinical utility. The International Ki67 in Breast Cancer Working Group has undertaken a systematic programme to determine whether Ki67 measurement can be analytically validated and standardised among lab
The wide variety of molecular architectures used in sensors and biosensors and the large amount of data generated with some principles of detection have motivated the use of computational methods, such as information visualization techniques, not only to handle the data but also to optimize sensing performance. In this study, we combine projection techniques with micro-Raman scattering and atomic
Blood flow measurements in the ascending aorta and pulmonary artery from phase-contrast magnetic resonance images require accurate time-resolved vessel segmentation over the cardiac cycle. Current semi-automatic segmentation methods often involve time consuming manual correction, relying on user experience for accurate results. The purpose of this study was to develop a semi-automatic vessel segme
Objective:Sleep duration has been related to overweight in children, but determinants of sleep duration are unclear. The aims were to investigate the association between sleep duration and childhood overweight adjusted for family characteristics and unhealthy behaviours, to explore determinants of sleep duration and to determine with sleep competing activities.Method:A cross-sectional study was ca
In the present work, f-wave morphology is characterized by principal component analysis and a novel temporal parameter defined by the cumulative normalized variance of the 3 largest principal components (r3). The 7-day behavior of persistent atrial fibrillation (AF) was studied in 9 patients using r3, AF frequency, and sample entropy (SampEn). Detection of circadian rhythms depended on the paramet
Background. Diagnosis of tuberculosis (TB) in human immunodeficiency virus (HIV)-coinfected individuals is challenging. We hypothesized that combinations of inflammatory markers could facilitate identification of active TB in HIV-positive individuals. Methods. Participants were HIV-positive, treatment-naive adults systematically investigated for TB at Ethiopian health centers. Plasma samples from
The stereoselective reduction of ketones by alcohol dehydrogenase from Thermoanaerobium brockii was studied in organic reaction media, 2-Propanol was used as co-substrate to regenerate the coenzyme NADPH. The enantiomeric excess of the alcohol formed from the ketone decreased during the course of the reaction (from 53 to 0% e.e. in the formation of (R)-2-butanol). This was interpreted as being due
BACKGROUND: Stress-related health problems (e.g., work-related exhaustion) are a societal concern in many postindustrial countries. Experience suggests that early detection and intervention are crucial in preventing long-term negative consequences. In the present study, we benchmark a new tool for early identification of work-related exhaustion-the Lund University Checklist for Incipient Exhaustio
The concentration of cartilage proteoglycan fragments in knee joint fluid was measured before and after one event of physical exercise in 33 healthy athletes. Nine athletes ran on a treadmill for 60 min, 16 ran on road for 80 min and 8 played one soccer game (90 min). Before exercise, the levels of proteoglycan fragments in the athlete joint fluid were lower than in a previously analyzed reference
This patent study researches the relation between competitive forces and the continuation of waves of Low Emission Vehicle (LEV) development. The competitive forces included are rivalry, dispersion referring to competition in general, and the presence of new entrants. We identify four waves of LEV development over the period 1990-2010, two of which were broken before becoming a commercial success,
