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Objective: To describe the design and rationale for the genetic analysis of acute and chronic cerebrovascular neuroimaging phenotypes detected on clinical MRI in patients with acute ischemic stroke (AIS) within the scope of the MRI-GENetics Interface Exploration (MRI-GENIE) study. Methods: MRI-GENIE capitalizes on the existing infrastructure of the Stroke Genetics Network (SiGN). In total, 12 inte
A rapid shift from traditional Sanger sequencing-based molecular methods to the phylogenomic approach with large numbers of loci is underway. Among phylogenomic methods, restriction site associated DNA (RAD) sequencing approaches have gained much attention as they enable rapid generation of up to thousands of loci randomly scattered across the genome and are suitable for nonmodel species. RAD data
BACKGROUND: Recipient age and donor age are well-known prognostic factors in adult heart transplantation. However, the association between donor age and recipient age and their interaction and short- and long-term mortality is unknown. METHODS: We studied 64,354 heart transplants to adult recipients between 1988 and 2013 in the ISHLT Registry. Donor age and recipient age were analyzed as continuou
Background: Diabetes is a risk factor for cognitive impairment, but whether there is also a link between pre-diabetes and cognitive dysfunction is not yet fully established. The aim of this observational study was to investigate associations between pre-diabetes/diabetes and cognitive test results, and also between glucose levels measured during the Oral Glucose Tolerance Test (OGTT) and cognitive
A reduced kinetic mechanism for methanol combustion at spark-ignition (SI) engine conditions is presented. The mechanism consists of 18 species and 55 irreversible reactions, small enough to be suitable for large eddy simulations (LES). The mechanism was reduced and optimized using the comprehensive mechanism (AramcoMech 2.0) as a starting point, to maintain performance at stoichiometric condition
Parasitoids foraging for larvae of Drosophila flies can use odours of adults of their hosts as well as odours of the food of their host larvae. Adult Drosophila deposit volatile aggregation pheromones into a substrate when mating and ovipositing. In this paper three species of parasitoids with different degrees of host specialization are compared in bioassays with regard to innate responses to agg
Antigens of the clinically important ABO and P1PK blood group systems are carbohydrate structures. Thus the underlying genes do not encode antigens directly but glycosyltransferases that add specific sugar molecules to selected precursor chains. The aim of this study was to investigate the transcriptional regulation of ABO and A4GALT, with an emphasis on interindividual differences. The up-and dow
Background:Dilatation of cranial vessels has been proposed as a part of the cascade that initiates an episode of migraine. This is based on the observation that intravenous administration of several substances with vasodilator properties can trigger migraine-like symptoms in migraineurs.Methods:We used in vitro myography of human cerebral arteries and in vitro pressurized arteriography of rat midd
We investigated the scale and characteristics of spring migration of soaring birds in Bourgas district, SE Bulgaria during three 5-day periods in March (27 th -31 st ), April (20 th -24 th ) and May (12 th -16 th ) 2008. Simultaneous counts were carried out from six observation points in two separate areas (Karnobat and Sredets), located 24.5 km and 37.3 km inland from the Black Sea coast, respect
Purpose. Patients with soft tissue sarcomas (STS) are at increased risk of second primary malignancies, including a second STS, but distinction between metastases and a second primary STS is difficult. Patients and Methods. Array-based comparative genomic hybridization (aCGH) was applied to 30 multiple STS of the extremities and the trunk wall from 13 patients. Different histotypes were present wi
Growing population in Swedish cities and limited natural resources combined with climate change impacts led decision-makers to develop densification strategies in city planning. However, densification could come with several challenges including reduced green spaces, increased urban heat island effect and energy demand, as well as the lack of thermal comfort in buildings. Densification becomes eve
Brottet hedersförtryck infördes i brottsbalken 2022. Enligt 4 kap. 4 e § BrB döms den som begår brottsliga gärningar enligt 3 eller 4 kap., 5 kap. 1 eller 2 §, 6 eller 12 kap. BrB eller enligt 24 § lagen (1988:688) om kontaktförbud mot en person med motiv att bevara eller återupprätta en persons eller familjs, släkts eller annan liknande grupps heder om var och en av gärningarna utgjort led i en uHonour oppression was introduced into the Swedish penal code in 2022. Anyone who commits criminal acts as defined in Chapters 3 or 4, Chapter 5, Sections 1 or 2, Chapters 6 or 12 of the Penal Code or under Section 24 of the Non-Contact Orders Act (1988:688), against another person with the motive of preserving or reestablishing the honour of a family, a larger group of relations or another similar
This study intends to map out the experiences of municipal employees regarding continuous workplace education. The goal of this study is to paint a better picture of employees' workplace education in the hopes of showing their benefits as well as giving employers clear points of improvement for further implementation. The study is qualitative based and uses interview based data with an inducti
This bachelor's thesis focuses on how scaling the pool diameter affects flammable liquids in an oxygen reduction system (ORS). This topic in the study of pool fire behavior in hypoxic air has been only lightly discussed in previous literature. Therefore, the goal of this thesis work is to further broaden the understanding of hypoxic air. This is done through experimental studies, examination o
Självutlämnande är en terapeutisk intervention som beskrivs som en av de mest hjälpsamma redskapen i en behandlingsprocess. Självutlämnande innebär att en terapeut delar personlig information eller erfarenheter om sig själv till sin klient eller när det används som en omedelbar respons på klienten i terapirummet. Studiens syfte var att utforska psykoterapeuters upplevelser av självutlämnande i terSelf-disclosure is a therapeutic intervention that is described as one of the most helpful tools in a treatment process. Self-disclosure implies that a person shares personal information or experiences about themselves to their client or when it´s used as an immediate response towards the client in the therapy room. The aim of the study was to investigate psychotherapists' experiences of self-
Världshälsoorganisationen har, med hänsyn till den världsomfattande urbaniseringen och åldrandet, föreslagit att tillgängliga grönområden i städers utomhusmiljöer är en viktig aspekt för det hälsofrämjande åldrande. Med anledning av att det främst är den äldre andelen av äldre som ökar globalt, fokuserar denna studie på att undersöka tillgängligheten av grönområden för de äldre som bor i boenden sThe World Health Organization, have due to the current worldwide urbanisation and ageing trends, proposed that having available Urban Green Spaces (UGS) is an important factor for ensuring healthy ageing in urban areas. Since it is particularly the oldest proportion of the older adults that are increasing in global population statistics, this study focused exclusively on available UGS based on old
Anthropogenic climate change has increased the frequency of extreme drought events and leads to “hotter” droughts. Topography controls plant available water and site-specific climatic conditions. Drought sensitivity may therefore vary over short distances between wet and dry locations of the landscape. However, topography is rarely included as a factor in research investigating vegetation dynamics
Purpose: The purpose of this thesis is to find out what pharmaceutical companies are doing in exploitation and exploration to improve R&D productivity. This research will also investigate the implications of management and control theories in combining exploration and exploitation in the context of pharmaceutical R&D. Methodology: Multiple case study interviews. Theoretical perspective
The usage of Artificial Intelligence is gaining popularity in many industries nowadays, triggering professionals to communicate about these disruptive changes in their industries. One industry has been looked at more profoundly: the executive search industry. Qualitative semi-structured interviews were conducted to gain more insight into the exploration of communicated strategies by professionals
The aim of this study was to explore how student’s alcohol consumption looks in different environments. The aim was also to explore if there was a connection between student’s alcohol consumption and environment´s indicators. The method used in this study was of a quantitative nature and the data was collected through surveys. The surveys were given out in six lessons and 279 students participated
