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International Society for Heart and Lung Transplantation Guidelines for the Evaluation and Care of Cardiac Transplant Candidates-2024

The "International Society for Heart and Lung Transplantation Guidelines for the Evaluation and Care of Cardiac Transplant Candidates-2024" updates and replaces the "Listing Criteria for Heart Transplantation: International Society for Heart and Lung Transplantation Guidelines for the Care of Cardiac Transplant Candidates-2006" and the "2016 International Society for Heart Lung Transplantation Lis

Critical time window of neuronal cholesterol synthesis during neurite outgrowth

Cholesterol is an essential membrane component enriched in plasma membranes, growth cones, and synapses. The brain normally synthesizes all cholesterol locally, but the contribution of individual cell types to brain cholesterol metabolism is unknown. To investigate whether cortical projection neurons in vivo essentially require cholesterol biosynthesis and which cell types support neurons, we have

Sound psychometric properties of the Swedish version of the Spinal Cord Independence Measure Self-Report

OBJECTIVE: To describe data completeness, targeting and reliability of the Swedish version of the Spinal Cord Independence Measure Self-Report (s-SCIM-SR). DESIGN: Translation and reliability study. SUBJECTS: Programme participants (n = 48) and peer mentors (n = 42) with spinal cord injury enrolled in the INTERnational Project for the Evaluation of "activE Rehabilitation" (inter-PEER). METHODS: Th

Computational Language Assessments of Harmony in Life - Not Satisfaction With Life or Rating Scales - Correlate With Cooperative Behaviors

Different types of well-being are likely to be associated with different kinds of behaviors. The first objective of this study was, from a subjective well-being perspective, to examine whether harmony in life and satisfaction with life are related differently to cooperative behaviors depending on individuals' social value orientation. The second objective was, from a methodological perspective, to

Life cycle assessment of the production of beet sugar and its by-products

This work presents estimates of the emissions resulting from the production of white sugar and its by-products (molasses, pressed beet pulp and dried beet pulp) from sugar beet cultivation to the final product at the factory gate. The study covers the impact of global warming potential, eutrophication potential (freshwater and marine) and particulate matter. The analysis was based on detailed prim

Patch Testing With Nickel Sulfate 5.0% Traces Significantly More Contact Allergy Than 2.5% : A Prospective Study Within the International Contact Dermatitis Research Group

Background Nickel allergy is the most common contact allergy, and a nickel salt is, therefore, included in most baseline patch test series. In the baseline series of the International Contact Dermatitis Research Group and the American Contact Dermatitis Society, nickel sulfate hexahydrate (NSH) in petrolatum at 2.5% is included, whereas NSH at 5.0% is included in many other baseline series, such a

Nonoccupational Allergic Contact Dermatitis to 4-Acryloylmorpholine in Smartwatch Screen Protectors Glue

Background We recently identified an outbreak of occupational allergic contact dermatitis (ACD) involving workers of a Spanish company selling smartphone protective cases from a glue product. A chemical analysis of one glue sample revealed the presence of 4-acryloylmorpholine among other allergens. The same glue is also used to attach tempered glass protective cases to Apple smartwatches. Objectiv

An evaluation of data processing when using the ActiGraph GT3X accelerometer in non-ambulant children and adolescents with cerebral palsy

PURPOSE: To evaluate vertical acceleration, vector magnitude, non-wear time, valid day classifications and valid period classifications, in the data processing phase when using the ActiGraph GT3X accelerometer in non-ambulant children and adolescents with cerebral palsy (CP).MATERIAL AND METHODS: Accelerometer data retrieved from 33 non-ambulant children and adolescents (4-17 years) with CP, were

Goals of Care Conversations Documented by an Embedded Emergency Department-Palliative Care Team during COVID

Background: There has been growing interest around integrating palliative care (PC) into emergency department (ED) practice but concern about feasibility and impact. In 2020, as the COVID pandemic was escalating, our hospital's ED and PC leadership created a new service of PC clinicians embedded in the ED. Objectives: To describe the clinical work of the embedded ED-PC team, in particular what was

The Role of Surgical Axillary Staging Prior to Immediate Breast Reconstruction in the Era of De-Escalation of Axillary Management in Early Breast Cancer

Postmastectomy radiotherapy (PMRT) following immediate breast reconstruction (IBR) is associated with postoperative complications. Although the incidence of node-positive breast cancer is declining, a separate sentinel lymph node biopsy (SLNB) is still performed before mastectomy when IBR is planned, in order to evaluate nodal status and the need for PMRT. This study assessed the impact of staged

Patients´ experiences of pain in the intensive care – The delicate balance of control

AimTo explore the patients´ experiences of pain when being cared for in the intensive care.DesignAn exploratory, qualitative design was chosen.MethodInterviews were performed with patients (October 2015–March 2017) within a week of post-intensive care (N = 16). Thematic analysis was used as method for analysis.ResultsThe findings generated two themes – a lack of control and to struggle for control

Suppression of T-Cell Proliferation by Normal Density Granulocytes Led to CD183 Downregulation and Cytokine Inhibition in T-Cells

Normal density granulocytes (NDGs) can suppress T-cell responses in a similar way as myeloid-derived suppressor cells (MDSCs). In this study, we tested the hypothesis that NDGs from healthy donors preferentially inhibit T helper 1 (Th1) cells and investigated the myeloid-derived suppressive effect in different T-cell populations. We found that NDG-induced suppression of T-cell proliferation was co

Estimated dietary exposure to pesticide residues based on organic and conventional data in omnivores, pesco-vegetarians, vegetarians and vegans

PURPOSE: To examine dietary exposure to 25 pesticide residues in several diet groups including omnivores, pesco-vegetarians, vegetarians and vegans while accounting for the farming system (organic or conventional) of plant-based foods consumed.METHODS: Organic and conventional consumption data in combination with data on pesticide residues in plant-based foods were used to derive estimated dietary

Investigation of the tightening function of a GPHE

Detta examensarbete presenterar resultatet av en utredning av ihopspänningen av en packningsförsedd plattvärmeväxlare. Projektets huvudfokus var att hitta en ny metod för att spänna ihop en packningsförsedd värmeväxlare some är mer exakt än den nuvarande metoden. Detta åstadkomms genom att ta hänsyn till tillverkningstoleranserna av de ingående delarna. Andra faktorer som antalet kanalplattor, matThis thesis presents the results of an investigation of the tightening function of a gasketed plate heat exchanger (GPHE). The main focus of the project has been to find a new method for tightening a GPHE that is more accurate than the current method. This is achieved by factoring in manufacturing tolerances of the ingoing parts. Other factors such as the number of channel plates, channel plate ma

Increased transmission and incidence of syphilis in southern Sweden 2007–2022

Syphilis has re-emerged as a public health threat during the 21st century, and updated knowledge of the epidemic and its drivers is needed to halt this worrying development. We present data on the incidence of syphilis in the south Swedish region Skåne from 2007 to 2022 to determine the burden of disease, changes in risk groups, as well as routes for testing. To get a picture of the burden of syph

The recent transformation of central squares : On the interrelation between retail, recreation and mobility

In this chapter I trace a series of central and well-connected urban squares in Malmö and Lund, Sweden from the 1960s until today. It investigates how the squares have developed in relation to the practice of shopping and other activities during these decades and concludes with the discussion of a few more recent trends. Starting with the deterioration of the open urban markets, followed by the in

High-throughput immunoassays for SARS-CoV-2–considerable differences in performance when comparing three methods

Background: The recently launched high-throughput assays for detecting antibodies against SARS-CoV-2 has contributed to the managing strategies for the COVID-19 pandemic. This study aimed to investigate the performance of three high-throughput assays and one rapid lateral flow test relative to regulatory authorities' recommended criteria. Methods: A total of 315 samples, including 150 pre-pandemic

Revising the ABIDE MCI to dementia prediction model for automated cerebrospinal fluid assays

INTRODUCTION: Automated cerebrospinal fluid (CSF) biomarker assays have largely replaced manual immunoassays for measuring amyloid pathology in CSF. We refitted and validated the ABIDE model, predicting progression from mild cognitive impairment (MCI) to dementia, with CSF measurements from the automated Elecsys platform. METHODS: We included 2413 MCI participants (998 [41%] amyloid-positive) from