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Many small companies ask themselves how and when to begin participating in the information revolution, and what changes this may bring to their business operation. Five typical models of product data integration were designed to help users to create a comprehensive view of the problems of technical information systems in companies. It was found that setting up an information system is a dynamic pr
BACKGROUND: In 2008, the Swedish government introduced a National Rehabilitation Program, in which the government financially reimburses the county councils for evidence-based multimodal rehabilitation (MMR) interventions. The target group is patients of working age with musculoskeletal disorders (MSD), expected to return to work or remain at work after rehabilitation. Much attention in the evalua
The main objectives of the present study were to monitor minimal residual disease (MRD) in the bone marrow of patients with mantle cell lymphoma (MCL) to predict clinical relapse and guide preemptive treatment with rituximab. Among the patients enrolled in 2 prospective trials by the Nordic Lymphoma Group, 183 who had completed autologous stem cell transplantation (ASCT) and in whom an MRD marker
Undersökning av Hsp21 med korslänknings-masspektrometriMänniskans kropp består av ungefär 30 trillioner celler och varje cell innehåller omkring 100 000 proteiner. Föreställ dig om kroppen vore jordklotet, varje vävnad ett land och varje cell en stad. Varje stad vore då konstant som Paris i rusningstrafiken. Trafiken vore helt galen hela tiden och väldigt känslig för även den minsta störning. CellSmall heat shock proteins (sHsps) are found in all organisms and evolved early in the history of life, prior to the divergence of the three domains of life (Archaea, Bacteria, and Eukarya). Their malfunction is connected to several different diseases in humans, such as Alzheimer’s and Parkinson’s disease. sHsps are especially abundant in plants, where most are highly upregulated as the first line
It is not known whether thyroid surgery evokes changes in calcium metabolism. We therefore studied 6 patients operated upon with hemithyroidectomy for benign thyroid diseases, preoperatively and at 3 months and 1 year postoperatively. We measured changes in serum levels of intact parathyroid hormone (PTH), vitamin D metabolites, ionized calcium, phosphate, osteocalcin, thyroid hormones and bone de
The end Ordovician (Hirnantian) extinction was the first of the five big Phanerozoic extinction events, and the first that involved metazoan-based communities. It comprised two discrete pulses, both linked in different ways to an intense but short-lived glaciation at the South Pole. The first, occurring at, or just below, the Normalograptus extraordinarius graptolite Biozone, mainly affected nekto
BACKGROUND: Experiencing work-life balance is considered a health promoting resource. To counter-balance the negative development of teachers' work situation, salutogenic resources need to be examined among teachers. OBJECTIVE: To examine resources related to teachers' experience of their work-life balance. METHODS: Using a cross-sectional design, a questionnaire was distributed to 455 teachers in
Primary retinal cell cultures and immunocytochemistry are important experimental platforms in ophthalmic research. Translation of retinal cells from their native environment to the in vitro milieu leads to cellular stress, jeopardizing their in vivo phenotype features. Moreover, the specificity and stability of many retinal immunochemical markers are poorly evaluated in retinal cell cultures. Henc
NMR spectroscopy provides valuable data for metabolomics, but the information sought can be partly obscured by errors from hardware imperfection, causing frequency, phase, and spectral lineshape to change significantly between measurements. Clearly, this is a highly undesirable source of variation in multivariate quantitative studies such as metabolomics. Fortunately,
BACKGROUND: Fetal cardiovascular MRI complements ultrasound to assess fetal cardiovascular pathophysiology.PURPOSE: To develop a free-breathing method for retrospective fetal cine MRI using Doppler ultrasound (DUS) cardiac gating and tiny golden angle radial sampling (tyGRASP) for accelerated acquisition capable of detecting fetal movements for motion compensation.STUDY TYPE: Feasibility study.SUB
Surgical patients are at high risk of developing postoperative cognitive dysfunction (POCD) and postoperative delirium (POD). POCD and POD are associated with increased morbidity and mortality and worsening functional outcomes leading to severe socioeconomic consequences for the patient and the society in general. Magnetic resonance imaging (MRI) offers a unique opportunity to study the anatomy an
Objective: Infliximab-treated patients with rheumatoid arthritis (RA) may respond insufficiently due to low serum infliximab (sIFX) levels, caused by anti-drug antibodies (ADAs). However, monitoring of sIFX and ADAs is not routinely implemented, and levels for optimal outcome have not been validated. We searched for predictors for sIFX < 0.2 μg/mL and ADA development in a randomized setting. Metho
During nine months, nineteen hairdressers every second/third month switched the use between a blow dryer with traditional design and one with a new design. The new blow dryer had the possibility to change between two opposite directed air flows. Every second/third month arm inclination angle and upper trapezius muscle activity were measured a whole workday, and during blow-drying in the laboratory
Rationale: Adults may exhibit characteristics of both asthma and chronic obstructive pulmonary disease (COPD), a situation recently described as asthma-COPD overlap (ACO). There is a paucity of information about ACO in primary care. Objectives: To estimate the prevalence and describe characteristics of individuals withACOin primary care practices among patients currently diagnosed with asthma, COP
Bariatric surgery results in notable weight loss and alleviates hyperglycemia in patients with type 2 diabetes (T2D). We aimed to characterize the vascular effects of a mixedmeal and infusion of exogenous glucose-dependent insulinotropic polypeptide (GIP) in the splanchnic region in 10 obese patients with T2D before and after bariatric surgery and in 10 lean control subjects. The experiments were
Många beteenden hos djur kan vara oflexibla och mer eller mindre ”hard-wired” i hjärnan. Sådana beteenden kan vara ändamålsenliga för regelbundna och rytmiska förändringar i naturen, såsom dag och natt, årstider, etc. Men många faktorer är naturligtvis oförutsägbara i naturen. För sådana oförutsägbara förändringar är det bättre för djur att vara flexibla i sitt beteende. Kognition är en process soThe Paridae (tits, titmice and chickadees) is a bird family consisting of both food hoarding and non-hoarding species. Many studies have been conducted on birds that are considered to be cognitively advanced, such as parrots and corvids, whereas much less is known about these small passerines. In this thesis, I have investigated the cognitive abilities of two members of the Paridae family; marsh t
Under the previous Employment Act No. 1475 employers had the right to dismiss any employee as they saw fit and there was no reinstatement for unfair or unjustified dismissal. However in the context of the national policy of harmonization with the European Union, the Turkish government introduced a new Act on job security (No. 4773). Then a new Employment Act (No. 4857), which included job security
Kognitiva och emotionella svårigheter är vanliga hos personer som överlevt ett hjärtstopp. Rutinerna för uppföljning efter hjärtstopp varierar stort mellan olika regioner och sjukhus i Sverige.För att förbättra vården har Svenska HLR-rådets arbetsgrupp för vård efter hjärtstopp tagit fram svenska riktlinjer för uppföljning efter hjärtstopp. According to previous research, a structured cardiac arrest follow-up may contribute to identifying health problems and the potential need of support among survivors and their relatives. However, a survey on post CA care and follow-up in Sweden, reported a lack of structure and major variations among Swedish hospitals. In 2016, Swedish guidelines were published with the aim to improve care. Accord
