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We have seen that protein kinase Calpha (PKCalpha) is transiently translocated to the plasma membrane by carbachol stimulation of neuroblastoma cells. This is induced by the Ca2+ increase, and PKCalpha does not respond to diacylglycerol (DAG). The unresponsiveness is dependent on structures in the catalytic domain of PKCalpha. This study was designed to investigate if and how the kinase activity a
Administration of insulin with premeal boluses of short-acting insulin using a new injection device (Novopen) was compared with a conventional three times daily injection regimen regarding aspects of quality of life and metabolic control in insulin-dependent diabetes mellitus (IDDM). Eighteen C-peptide-negative patients with IDDM (16 men, two women, aged 31.0 ± 7.4 years, duration of diabetes 13.
BACKGROUND: Anisakis simplex, a fish parasite, causes allergic urticaria, angioedema and anaphylactic shock through an IgE-mediated hypersensitivity mechanism. Consensus on the dietary recommendations that should be given to allergic patients is lacking. Our objective was to evaluate the usefulness of different types of diets in preventing further reactions in patients allergic to A. simplex. METH
The pseudo-Thellier technique was applied to recover relative palaeointensity (PT-RPI) estimates from four piston cores retrieved from a Holocene lake sediment sequence in the province of Smaland, central southern Sweden. A time-depth model between 11,000 and 450 cal BP was based on a combination of calibrated radiocarbon ages and the ages of established palaeomagnetic secular variation (PSV) feat
INTRODUCTION: Radiographers' engagement in research is important for the development of evidence-based practice in radiography; however, radiographers' interest in research has rarely been reported. This study sought to ascertain radiographers' opinions about radiography research and investigate their involvement in research activities in four Nordic countries.METHODS: This study was conducted in
Introduction: Treatment-induced peripheral neuropathy (TIPN) is a complication of multiple myeloma (MM) treatment. Objective: This real-world, retrospective study used electronic medical record (EMR) data from 3 Swedish clinics to assess the occurrence and economic burden of TIPN in patients with MM. Methods: Eligible patients had an MM diagnosis in the Swedish Cancer Registry between 2006 and 201
Background: Contamination of drinking water by hazardous chemicals can be associated with human health risks. Recent studies using effect-based in vitro methods have demonstrated that a large part of the observed toxic effects are caused by unknown chemicals. In this study, we have used a panel of effect-based methods to study the presence of chemical contaminants in a unique material; glass-bottl
CONTEXT: Understanding factors involved in the rate of C-peptide decline is needed to tailor therapies for type 1 diabetes (T1D). OBJECTIVE: Evaluate factors associated with rate of C-peptide decline after a T1D diagnosis in young children. DESIGN: Observational study. SETTING: Academic centers. PARTICIPANTS: A total of 57 participants from the Environmental Determinants of Diabetes in the Young (
Introduction How the burden of disease varies during different phases after floods and after storms is essential in order to guide a medical response, but it has not been well-described. The objective of this review was to elucidate the health problems following flood and storm disasters.Methods: A literature search of the databases Medline (US National Library of Medicine, National Institutes of
Antisense oligonucleotides (ASO) are DNA-based, disease-modifying drugs. Clinical trials with 2'-O-methoxyethyl (2'MOE) ASO have shown dose- A nd sequence-specific lowering of platelet counts according to two phenotypes. Phenotype 1 is a moderate (but not clinically severe) drop in platelet count. Phenotype 2 is rare, severe thrombocytopenia. This article focuses on the underlying cause of the mor
This research studied the preferences reported by women and men about their Ideal Body Image for the Opposite Sex (IBIOS), and its association with body mass index (BMI). It also analysed the preferences of each sex for a woman's ideal body image (W-IBI) and a man's ideal body image (M-IBI). A total of 450 participants aged 18-70 years with different weights were studied. Their IBIOS was assessed
BACKGROUND: Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is a treatment strategy for pseudomyxoma peritonei (PMP) with curative intent. The aim of this study was to determine the patterns of failure in patients who underwent such a procedure and to evaluate management and outcome of progressive disease.METHODS: After exclusion of patients with overt malignancy
We conducted a phase I-IIa, randomized, monocentric, double-blind, placebo-controlled clinical trial to evaluate the safety and impact of the combination treatment of Itolizumab and insulin on preserving beta cell function in adults with recent-onset type 1 diabetes. Twelve patients were randomly assigned to three treatment groups, each receiving a different Itolizumab dose (0.4/0.8/1.6 mg/kg body
Introduction: To remain competitive, industrial organisations are continually faced with the challenges to improve product quality, reduce product development time, reduce production costs and lead-times. Increasingly, these challenges cannot be effectively met by isolated changes to specific organizational units. The Supply Chainis a revolutionary concept embedded in a traditional guise. In b
In this project, we are studying the material flow and the information flow of sample materials and the appurtenant report of deviation for the purpose to be able to suggest better solutions. The sample material, which is to be analysed, is to be continuously taken from the production flow. The purpose is to navigate the process by the results found by the analysis. Because of this, it's very
Bariatric surgery results in notable weight loss and alleviates hyperglycemia in patients with type 2 diabetes (T2D). We aimed to characterize the vascular effects of a mixedmeal and infusion of exogenous glucose-dependent insulinotropic polypeptide (GIP) in the splanchnic region in 10 obese patients with T2D before and after bariatric surgery and in 10 lean control subjects. The experiments were
This thesis concerns the relationship between grammar education and writing. This is approached in two ways, which are expressed in the two research questions. They are as follows: Does grammar education improve students texts and does grammar education affect students writing processes. The method used to investigate the research questions, is an elicitation task which has generated texts from un
Bristen på personal inom människorelaterade yrken som till exempel vård och omsorg är idag ett problem som behöver lösas. En möjlig lösning skulle kunna vara att höja individers communal yrkesmål (vilja att arbeta med människor). Syftet med denna uppsats är att undersöka om compassion meditation, en metod som syftar till att höja medkänsla/medlidande, kan höja gymnasieelevers communal yrkesmål. I Sweden is witnessing a shortage of labor within the social and healthcare sector. A viable option that could bring Sweden one step closer to a solution is to raise the populations' communal goals. Our study aims to explore if compassion meditation, a method that aims to cultivate compassion can raise communal goals amongst Swedish high school students. Within this study, 250 students attending
Semiconductor nanowires, with their quasi one-dimension geometry, inherently provide strain relaxation for heterogeneous integration and also strong light mode confinement. Nanowire-based photonic devices have also been demonstrated to offer significantly enhanced quantum efficiency, gain and reduced noise. This project deals with electro-optical investigations of InP nanowires with axially embedd
The purpose of this thesis was to study and find a solution for the safety problem of workers, pedestrians and bicyclists who take shortcuts through civil work construction sites. It focuses on the situation at one specific project, but the conclusions are general for all construction work sites. The thesis includes literature studies, interviews, a questionnaire survey and observation studies. Th
