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Metodutveckling för analys av cellulärt upptag av nanopartiklar Cancer är idag en utbredd sjukdom som tusentals människor världen över diagnostiseras för dagligen. Möjligheterna att få en korrekt behandling ökar om tumörer upptäcks i ett tidigt skede tidigt vilket ger en större chans att tillfriskna. Men detta har visat sig vara en utmaning då nuvarande metoder som används inte är av tillräckligAbstract MRI, magnetic resonance imaging, is used for disease detection such as assessing blood flow, detecting tumours and diagnosing many forms of cancer. Contrast agents are chemical substances that increase the MRI sensitivity. One class of contrast agents are the so called nanoparticulate contrast agents. Since tumour-associated formation of new blood vessels often results in highly permeab

Syftet med föreliggande studie var dels att beskriva den grupp som spelar massiva onlinespel (MMO), dels att undersöka vilka faktorer som har betydelse för ett eventuellt problematiskt datorspelande. Analysen baserades på 429 svar från deltagare som fyllt i en webbenkät bestående av flervalsfrågor fördelade på skalorna prestation, social interaktion, självreaktiv förväntan, flow, bristfällig självThe aim of this study was to provide a description of the Swedish massively multiplayer online (MMO) community, and to investigate factors pertinent to problematic gaming. The analysis was based on 429 answers from a multiple-choice web-based survey with questions spread across the following scales: achievement, social interaction, self-reactive outcome expectations, flow, deficient self-regulatio

We report on the fabrication and transport properties of single-walled carbon nanotubes (SWCNT) blended with P3HT (poly 3-hexyl thiophene-2, 5-diyl). The composite is used as a hybrid organic active channel transistor. The performances of the fabricated devices were investigated as a function of the SWCNTs' loads in the composite, and their response evaluated under white light illumination. Our re

The effects of a pesticide mixture (asulam, fluazinam, lambda-cyhalothrin, and metamitron) on aquatic ecosystems were investigated in 20 outdoor aquatic microcosms. Ten of the microcosms simulated mesotrophic aquatic ecosystems dominated by submerged macrophytes (Elodea). The others simulated eutrophic ecosystems with a high Lemna surface coverage (Lemna). This paper describes the fate of the chem

BACKGROUND: Perfluoroalkyl substances (PFAS) are widespread synthetic substances with various adverse health effects. Not much is known about the modes of action of PFAS toxicity, but one likely mechanism is alteration of microRNA expression.OBJECTIVES: To investigate whether PFAS exposure is associated with altered microRNA expression in serum.METHODS: We selected women from the Ronneby cohort, w

The objective was to investigate if diffusing laser fibres can be modelled as conductive heat sources without miscalculating coagulated volumes, and if finite element analysis, disregarding light transport, may be used for three dimensional (3D) treatment planning in interstitial laser thermotherapy (ILT). Temperature distributions and coagulated volumes with a diffusing laser fibre, as compared t

Background: The relationship between coffee consumption and mortality in diverse European populations with variable coffee preparation methods is unclear. Objective: To examine whether coffee consumption is associated with all-cause and cause-specific mortality. Design: Prospective cohort study. Setting: 10 European countries. Participants: 521 330 persons enrolled in EPIC (European Prospective In

Humid air motor (HAM) is an engine operated with humidified inlet charge. System simulations study on HAM showed the waste heat recovery potential over a conventional system. An HAM setup was constructed, to comprehend the potential benefits in real-time, the HAM setup was built around a 13-litre six cylinder Volvo diesel engine. The HAM engine process is explained in detail in this paper. Emissio

Levosimendan is an inodilatory drug that mediates its cardiac effect by the calcium sensitization of contractile proteins. The target protein of levosimendan is cardiac troponin C (cTnC). In the current work, we have studied the interaction of levosimendan with Ca2+-saturated cTnC by heteronuclear NMR and small angle x-ray scattering. A specific interaction between levosimendan and the Ca2+-loaded

Background and purpose — The outcome of surgical treatment of lumbar disc herniation (LDH) has been thoroughly evaluated in middle-aged patients, but less so in elderly patients. Patients and methods — With validated patient-reported outcome measures (PROMs) and using SweSpine (the national Swedish Spine Surgery Register), we analyzed the preoperative clinical status of LDH patients and the 1-year

OBJECTIVE: It has been shown that [(18)F]-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) can identify macrophage-rich high-risk atherosclerotic plaques in animal models as well as in patients with atherosclerotic plaques in the carotid arteries. The development of inflamed macrophage-rich plaques over time is not well known. This study was performed to determine t

Males of all species of the parasitic wasp genus Nasonia use (4R,5S)-5-hydroxy-4-decanolide (RS) as component of their sex pheromone while only N. vitripennis (Nv), employs additionally (4R,5R)-5-hydroxy-4-decanolide (RR). Three genes coding for the NAD + -dependent short-chain dehydrogenases/reductases (SDRs) NV10127, NV10128, and NV10129 are linked to the ability of Nv to produce RR. Here we sho

This paper deals with theoretical and experimental investigations of nailed steel plate connections. For the experimental part, a total of 99 laboratory tests have been carried out in order to study failure mechanism and shear capacity of nailed steel plate connections. The testing programme comprised two nail lengths, two steel plate thicknesses and five nailing patterns. All tests related to loa

Orchid species are critically dependent on mycorrhizal fungi for completion of their life cycle, particularly during the early stages of their development when nutritional resources are scarce. As such, orchid mycorrhizal fungi play an important role in the population dynamics, abundance, and spatial distribution of orchid species. However, less is known about the ecology and distribution of orchi

Although recommended by the Kidney Disease Improving Global Outcomes, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPICR) creatinine equation was not targeted to estimate glomerular filtration rate (eGFR) among older adults. The Berlin Initiative Study (BIS1CR) equation was specifically developed in older adults, and the Lund-Malmö revised (LMRCR) and the Full Age Spectrum (FASCR) eq

Delayed-return foraging strategies connected with a sedentary lifestyle are known from Late Mesolithic Scandinavian settlements. However, recent evidence from the archaeological site of Norje Sunnansund, in south-eastern Sweden, indicates the presence of sedentism from the Early Mesolithic. By analyzing the faunal assemblage from Norje Sunnansund, patterns of delayed-return strategies were examine

The aim of this study was to examine the level of physical activity in adults with cerebral palsy (CP) and to analyse its relationship with physical activity as adolescents, pain, and gross motor function. A prospective cohort study was performed using data from the Swedish National CP Registry (CPUP) for all 129 individuals born in 1991-1993 living in Skåne and Blekinge who reported to CPUP at 14

This laboratory study examined human stair ascending capacity and constraining factors including legs’ local muscle fatigue (LMF) and cardiorespiratory capacity. Twenty-five healthy volunteers, mean age 35.3 years, with maximal oxygen uptake (VO2max) of 46.7 mL·min-1·kg-1, and maximal heart rate of 190 bpm, ascended on a stair machine at 60% and 75% (3 min each), and 90% of VO2max (5 min or until

We have earlier shown that both full-length and truncated glycosylated tissue factor pathway inhibitor (TFPI) lacking the third Kunitz domain and the c-terminal region has an antithrombotic effect comparable to low-molecular-weight heparin (LMWH) in an experimental venous thrombosis model. The aim of this study was to investigate whether a recombinant truncated non-glycosylated TFPI (117QTFPI1-161