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Background and aims Diet and smoking expose the general population to cadmium (Cd), which is a toxic metal that accumulates in the arterial wall. In experimental studies, Cd causes reductions in proliferation of smooth muscle cells and cellular synthesis of procollagen. The aim of this study was to examine whether blood Cd levels, a valid measure of Cd exposure, are associated with increased risk
Background: Prognostic factors in patients with localized primary cutaneous malignant melanoma (CMM) are well described. However, prognostic factors for recurrence are less documented. Objectives: The aim of this study was to identify prognostic risk factors for first recurrence in patients with localized stages I-II CMM using population-based data. Methods: This study included 1437 CMM patients r
Petrographic analysis of eight CM carbonaceous chondrites (EET 96029, LAP 031166, LON 94101, MET 01072, Murchison, Murray, SCO 06043, QUE 93005) by electron imaging and diffraction, and X-ray computed tomography, reveals that six of them have a petrofabric defined by shock flattened chondrules. With the exception of Murchison, those CMs that have a strong petrofabric also contain open or mineraliz
Background For patients with atrial fibrillation, non-vitamin K oral anticoagulants, or NOACs (dabigatran, rivaroxaban, edoxaban, and apixaban) have been proven non-inferior or superior to warfarin in preventing stroke and systemic embolism, and in risk of haemorrhage. In the pivotal NOAC studies, quality of warfarin treatment was poor with mean time in therapeutic range (TTR) 55–65%, compared wit
BACKGROUND: Neonatal hypoxic ischemic encephalopathy (HIE) is a devastating condition resulting from a sustained lack of oxygen during birth. The interest in identifying a relevant biomarker of HIE has thrown into limelight the role of protein S100B as a clinical diagnostic marker of hypoxic brain damage in neonates.AIMS: To evaluate the diagnostic value of protein S100B, measured in umbilical cor
Background. Reconstruction of the right ventricular outflow tract with a conduit is an established surgical procedure in congenital heart disease and reinterventions are common. Objective. An increasing number of patients have a conduit, but there are few population-based studies of long-term outcomes after conduit surgery, reoperations, and transcatheter pulmonary valve replacement. Methods. In A
Popular Abstract in Swedish Prosodi definieras som talets rytmiska, dynamiska och melodiska egenskaper (Bruce, 1998). Till de prosodiska dragen hör längd (kvantitet), betoning (tryck- och ordaccent), ton, satsmelodi (intonation) och gränser (tomrum i talvågen). Dessa drag används i kommunikativt syfte för att särskilja betydelser hos ord och orddelar, för att framhäva och gruppera delar av talet oThe aim of this thesis was to explore prosodic problems in Swedish children with language impairment (LI). In the first study, 29 children with LI participated. They were assessed with an assessment procedure for prosody at the word, phrase and discourse levels, developed within this thesis. The results showed that 41% of the children had prosodic problems to some extent. In addition, reliability
Popular Abstract in Swedish Sortering av bakteriedödande proteiner till behållarna i vita blodkroppar Vita blodkroppar har en livsviktig roll i det medfödda immunförsvaret som fagocyter, bakterieätare. Denna funktion, första linjens försvar, utövas av neutrofila granulocyter (neutrofiler), en speciell slags vita blodkroppar som är specialiserade på bakterieätning (fagocytos). När bakterier angripThe neutrophil granulocytes have a critical role in innate immunity in particular through phagocytosis of microorganisms. Their cytoplasmic granule subsets store digestive enzymes and antibiotic proteins that are released during this event. During the passage in the secretory pathway the granule proteins are retrieved from constitutive secretion to become sorted for storage. The aim of this thesis
BACKGROUND AND OBJECTIVE: Ultrasound has become an increasingly popular modality in facilitating the performance of peripheral nerve blocks. There exists no literature that examines the learning curve of the ultrasound novice. In this prospective series, we evaluated the learning curve of inexperienced anesthesia residents in performing a simulated ultrasound-guided interventional procedure. In do
Background: Gadolinium contrast media (Gd-CM) are regarded as non-nephrotoxic or considerably less nephrotoxic than iodine contrast media (I-CM), and have therefore come to be used as a substitute for I-CM in patients with renal insufficiency in a variety of radiographic examinations. Purpose: To investigate renal histomorphological changes caused by Gd-CM in comparison with I-CM after renal X-ra
We conducted a first pilot study on healthy women living in two countries with different dietary habits, Granada in the south of Spain and Malmo in the south of Sweden, in order to compare their levels of plasma phospholipid fatty acids, and to examine the relationship between the differences in food consumption. This study is part of a pilot study which is nested in the European Prospective Inves
Background. The aims of the present study were to (1) analyze preoperative predictors for outcome suggested by Hardman and surgical mortality after open repair and endovascular repair (EVAR) of ruptured abdominal aortic aneurysms (rAAA), and (2) further evaluate the Hardman index in a systematic review. Methods. Patients operated on for rAAA during a 5-year period between 2000 and 2004 were scored
Popular Abstract in Swedish Avhandlingen utgångspunkt tas från den senmesolitiska boplatsen vid Motala ström, Motala stad, Östergötland, Sverige. Problematiken som diskuteras i texten utgår från frågeställningarna vad som formade de materiella uttrycken under en 500-årig tidsperiod, 5500-5000 f.Kr, dokumenterade genom arkeologiska undersökningar. Texten i avhandlingen är i analysen strukturerad i This dissertation focuses on the Strandvägen site located in the town of Motala, Östergötland, Sweden. The problem concerns what shaped the material expressions on the site during 5500?5000 B.C. For reasons of text structure the space outside the settlement site (the home) is divided into the world, the district, and the neighbourhood. These spatial concepts are finally brought together in the syn
Background. Artificial neural networks have successfully been applied for automated interpretation of myocardial perfusion images. So far the networks have used data from the myocardial perfusion images only. The purpose of this study was to investigate whether the automated interpretation of myocardial perfusion images with the use of artificial neural networks was improved if clinical data were
Background. The aim of this study was to investigate differences in use of antenatal care in a multi-ethnic population in Malmo, Sweden, over a 4-year period. Age, parity, cohabiting status, use of an interpreter, and tobacco-use were examined to assess the potential effects of confounding factors. Methods. A 4-year (2000-2003) retrospective community-based register study was performed. Low-risk s
BACKGROUND: The role of cholecystokinin (CCK) and gastrin in the development and growth of pancreatic cancer cells is controversial. The aim of this study was to evaluate the role of CCK-8S, gastrin-17, bombesin, and their antagonists on cell lines from patients with pancreatic cancer. METHODS: Cell lines were established from pancreatic cancers operated on at our department. The cells were grown
Objective. A refrigerator-stable formulation of ProQuad has been developed to expand the utility of ProQuad to areas in which maintenance of a frozen cold chain (- 15 degrees C or colder) during storage and transport may not be feasible. The objective of this study was to demonstrate that the immunogenicity and safety profiles of a refrigerator-stable formulation of ProQuad are similar to the rece
Intraocular lens (IOL) exchange after cataract surgery is unusual but may be associated with suboptimal visual outcome. The incidence of IOL exchange has not been consistently estimated. Such information is invaluable when counseling patients prior to cataract surgery. We examined the incidence of, and indications and risk factors for, IOL exchange after cataract surgery. We also assessed visual o
Aims: Research on the effect of unmet health-care needs on mortality at follow-up is scarce. This study investigated whether unmet health-care needs in 2008 were associated with a higher risk of mortality during a five-year follow-up period in a population in southern Sweden, and whether the association was stronger for particular subgroups of cause of death. Methods: The 2008 public-health survey
Objective To compare several methods of missing data imputation for function (Health Assessment Questionnaire) and for disease activity (Disease Activity Score-28 and Clinical Disease Activity Index) in rheumatoid arthritis (RA) patients. Methods One thousand RA patients from observational cohort studies with complete data for function and disease activity at baseline, 6, 12 and 24 months were sel
