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Background: Win statistics offer an alternative approach to clinical trials that use survival analysis to analyze composite endpoints. Our objective was to re-analyze data from previously published registry-based randomized controlled trials that produced hazard ratios using win statistics to evaluate the correspondence between them. Good correspondence was defined as both results being positive,

Landslide susceptibility mapping is among the first works for disaster management and land use planning activities in a mountain area like Ganzhou City. The aims of the current study are to assess GIS-based landslide spatial modeling using four models, namely data-driven evidential belief function (EBF), frequency ratio (FR), maximum entropy (Maxent), and logistic regression (LR), and to compare t

This thesis discusses how teachers’ experiences of teaching online is related to how they chose to teach. Previous research has shown that contextual factors can influence how teachers go about their teaching, and when university courses leave the physical campus and move to an online environment, this entails a change of context. The research presented here focuses on teachers’ experiences and ch

BACKGROUND: Vacuum-assisted abdominal closure (VAC) is being increasingly used as an adjunctive procedure in the surgical treatment of secondary peritonitis. This study compared postoperative mortality and complication rates between VAC and primary abdominal closure (PAC).METHOD: This retrospective chart review included all patients diagnosed with secondary peritonitis who underwent laparotomy bet

Legumin and vicilin, the main storage proteins from peas, are increasingly employed as functional ingredients for food. The purpose of this work was to better understand the interactions between these proteins and selected lipids, due to their potential consequences on interfacial functionality of protein preparations. Legumin and vicilin isolates were obtained after isoelectric precipitation foll

BACKGROUND: The incidence of postural orthostatic tachycardia syndrome (POTS) in long COVID has been a growing concern since the first cases were reported in 2021. The aim of this study was to assess the prevalence and clinical impact of POTS in a series of well-characterized patients with long COVID.METHODS: We prospectively analyzed 467 nonhospitalized, highly symptomatic (sick leave ≥50%) patie

Abstract in Italian Negli ultimi trent’anni il sindacato ha iniziato a perdere valenza sotto il profilo nazionale, questo soprattutto a causa del declino degli iscritti a tali organizzazioni. Declino che ha interessato, bene o male, tutti i paesi occidentali, dall’Europa agli Stati Uniti d’America. Ciononostante (o proprio per questo), gli studiosi delle relazioni industriali e della sociologia de

Objectives: Timely discovery and adequate patient management are crucial in non-small cell lung cancer (NSCLC) since long-term survival is only achievable in early-stage disease. In our study, we aimed to elucidate the effects of time to surgery on survival and to assess the impact of the COVID-19 pandemic on elapsed time until surgery. Methods: In total, 2536 Caucasian NSCLC patients who underwen

Background: Testicular germ cell cancer (TGCC) originates during fetal life. Fetal exposure to environmental chemicals may contribute to its development, but epidemiological data are lacking. We investigated per- and polyfluoroalkyl substances (PFAS), which can act as endocrine disruptors during fetal development, and TGCC risk in adulthood. Methods: We conducted a nested case-control study of 549

This thesis aims to investigate the novel physics around Majorana bound states (MBSs). MBSs are quasiparticle excitations predicted to exist in topological superconductors. Due to the inherent protection they obtain from their topology, they have long been regarded as a promising setup to build a topologically protected quantum computer. Apart from this very practical application, they continue to

Cardiovascular disease (CVD) is the leading cause of death in Europe, with myocardial infarction (MI) being one of its most severe manifestations. While many risk factors for CVD are well known, occupational exposures remain relatively understudied—especially in analyses that adjust for co-occurring workplace exposures. This study aimed to examine the association between occupational exposure to c

Proteins and peptides are vital biomolecules, and deuterated amino acids are increasingly applied in areas such as drug discovery, metabolic tracing, and neutron scattering studies. In this study, we performed deuteration on all 20 proteinogenic amino acids, including their side chains, and established efficient methods for 13 amino acids. Using a Pt/C-catalyzed hydrogen–deuterium exchange reactio

Purpose: To evaluate a new analytical estimator for R1 and apparent proton density (𝐴) from short-TR dual flip angle data which does not rely on the small flip angle approximation and can thus be applied to a broader range of data, especially where relatively large flip angles are needed to achieve sufficient T1-weighting for R1 estimation.Theory and Methods: A rational approximation of the Ernst

Considering the distinct etiological pathways and molecular characteristics of different lung cancer subtypes, it is crucial to develop subtype-specific prevention strategies and therapeutic targets. This study aimed to identify protein biomarkers and potential therapeutic targets for specific subtypes of lung cancer by integrating population-based observational studies and Mendelian randomisation

Background and aims: This randomized cross-over study in healthy volunteers was designed primarily to evaluate the potential impact of investigator gender on electrical pain threshold (EPT) and corresponding pain intensity levels, and secondly to evaluate potential differences in those interventions between female and male study participants. Methods: Forty adult volunteers (22 females) were inclu

MethodsRecent randomized control trials (RCTs) have confirmed that antibiotics in acute uncomplicated diverticulitis (AUD) neither accelerate recovery nor prevent complications or recurrences.A retrospective cohort study was conducted, including all consecutive AUD patients hospitalized 2015- 2018 at Helsingborg Hospital (HH) and Skåne University Hospital (SUS), Sweden. HH had implemented a non-an

ABSTRACT: Baz-Valle, E, Fontes-Villalba, M, and Santos-Concejero, J. Total number of sets as a training volume quantification method for muscle hypertrophy: A systematic review. J Strength Cond Res 35(3): 870-878, 2021-This review aimed to determine whether assessing the total number of sets is a valid method to quantify training volume in the context of hypertrophy training. A literature search o

BackgroundHome care is beset with work environment issues and high staff turnover, while research concerned with interventions to improve the work environment is sparse. Few of the existing interventions apply a participative approach, despite this being associated with more positive outcomes and sustainable change. This paper presents a framework, rooted in action research and action learning, fo

Prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) is effective against prostate cancer (PCa), but all patients relapse eventually. Poor understanding of the underlying resistance mechanisms represents a key barrier to development of more effective RLT. We investigate the proteome and phosphoproteome in a mouse model of PCa to identify signaling adaptations triggered by P