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The impact of factor V mutation on the risk for occlusion in patients undergoing peripheral vascular reconstructions

OBJECTIVE: to determine the impact of Factor V-Leiden on the patency of peripheral vascular reconstructions. DESIGN: prospective, open and consecutive study. METHODS: a total of 775 patients, who were electively admitted between 1995 and 1997 to the vascular ward unit, were prospectively analysed for frequency of Factor V-Leiden mutation and patency of reconstruction (one month and one year). The

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Popular Abstract in Swedish Som ett skepp uti vilda havet, den kristna församlingen i ärkebiskop Laurentius Petris verk I 1593 års Uppsala mötes "förening om läran, ceremonier och kyrkotukt" finns följande avsnitt : Thernäst bejake och vederkännes vi oss alldeles vele holle vidh the Apostoliske, Niceniske och Athanasii symbola, såsom och vidh then äldste, rätte och oförrandrede Ausburgiske confeThe aim of this thesis is to present the ecclesiology of Laurentius Petri, a former student at Wittenberg who was archbishop of Uppsala from 1531 to his death 1573. He had a decisive role in the founding of the Church of Sweden, especially through his Swedish Church Ordinance(1571). Nevertheless most of his seventy-three writings are little known and have been rarely studied. Chapter one st

Albuminuria and associated medical risk factors: a cross-sectional study in 451 type II (noninsulin-dependent) diabetic patients. Part 2

The association between urinary albumin concentration (UAC) in a morning urine sample and medical risk factors was evaluated in a cross-sectional study of 451 type II (noninsulin-dependent) diabetic patients. The following four groups of patients were created according to their urinary albumin levels: A) normal (less than 12.5 mg/L); B) high normal (12.5-30 mg/L); C) microalbuminuria, ie, incipien

High-risk HPV and survival in patients with oral and oropharyngeal squamous cell carcinoma - 5-year follow up of a population-based study.

Abstract Conclusion: No statistically significant 5-year survival difference was seen in patients with oral and oropharyngeal squamous cell carcinoma (OOPSCC) between high-risk HPV-positive and -negative groups in this population-based study. Objectives: To see if the formerly observed higher risk for recurrence or second primary tumour (SPT) in high-risk HPV-positive patients with OOPSCC correspo

Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population

We determined whether single nucleotide polymorphisms (SNPs) previously associated with diabetogenic traits improve the discriminative power of a type 2 diabetes genetic risk score. Participants (n = 2,751) were genotyped for 73 SNPs previously associated with type 2 diabetes, fasting glucose/insulin concentrations, obesity or lipid levels, from which five genetic risk scores (one for each of the

Clustering of concordant and discordant cancer types in Swedish couples is rare

Background: Spouses are exposed to common environmental cancer risk factors during adulthood. Investigating the aggregation of cancer in couples might provide valuable insights into cancer development. Methods: The 2008 update of the Swedish Family-Cancer Database includes over 2 million couples with at least one child in common with one single partner. We quantified the contribution of shared adu

Beyond conventional stroke guidelines - Setting priorities

Background and Purpose - Priorities in the care of stroke patients are often intuitive. An open and translucent priority-setting procedure would benefit patients, professionals, and decision-makers. Prioritization is an innovative part of the new Swedish national stroke guidelines. Methods - Working groups identified diagnostic procedures, interventions and therapies in stroke care, assessed each

Lipid deposition in Kupffer cells after parenteral fat nutrition in rats: a biochemical and ultrastructural study

OBJECTIVE: To study fat metabolism and evaluate lipid deposition in hepatocytes and Kupffer cells during parenteral nutrition (PN) with or without fat. DESIGN: 20 male Sprague-Dawley rats, divided into four groups, were investigated. Rats fed orally were used as a reference group and compared to three groups of rats receiving PN either without fat or with 33% of non-protein energy as fat or with 6

Amplitude-integrated EEG (aEEG) predicts outcome after cardiac arrest and induced hypothermia.

Objective To evaluate the use of continuous amplitude-integrated EEG (aEEG) as a prognostic tool for survival and neurological outcome in cardiac arrest patients treated with hypothermia. Design Prospective, observational study. Setting Multidisciplinary intensive care unit in a university hospital. Intervention Comatose survivors of cardiac arrest were treated with induced hypothermia for 24 h. A

PTSD and ADHD: underlying factors in many cases of burnout

Objective: To analyse the extent to which traumatic life events, post-traumatic stress disorder (PTSD) and the neuropsychiatric disorder attention deficit hyperactivity disorder (ADHD) can be contributors associated with burnout and the long-term sick leave that results from it. Subjects: Sixty-two individuals on long-term sick leave due to stress-related poor health and burnout, and 83 working in

Both empowered and powerless: mothers' experiences of professional care when their newborn dies.

The death of a newborn is a complex and tragic situation, the uncertain and stressful nature of which places emotional burdens on the parents. The aim of this study was to examine and illuminate mothers' experiences and perceptions of the care given to them at neonatal clinics while facing the threat and the reality of losing their baby. METHOD: Interviews were performed, in the form of conversati

Småländsk världsindustri - en studie om entreprenörer och kluster 1950-2002

The thesis describes and analyzes six companies’ origins and development over the period 1950-2002, a time when the Swedish industrial sector was dominated by companies that were formed in the early 1900s. The firms, situated in the same region, have after an eventful journey become world leaders in the segment of machines with capacity to lift more than five tonnes. Investigations in Swedish busi

Management of plant communities on set-aside land and its effects on earthworm communities

Plant communities of set-aside agricultural land in a European project were managed in order to enhance plant succession towards weed-resistant, mid-successional grassland. Here, we ask if the management of a plant community affects the earthworm community. Field experiments were established in four countries, the Netherlands, Sweden, the UK, and the Czech Republic. High (15 plant species) and low

Respiratory symptoms are poor predictors of concomitant chronic obstructive pulmonary disease in patients with primary Sjögren’s syndrome

Involvement of the respiratory system, in particular dry airways and chronic obstructive pulmonary disease (COPD), is common in patients with primary Sjögren’s syndrome (pSS). As respiratory symptoms are also common in pSS patients and may have different etiologies, we wanted to evaluate the amount and impact of respiratory symptoms in out-patients with pSS and to assess if such symptoms are relat

Single and multiple cardiovascular biomarkers in subjects without a previous cardiovascular event

Aims To assess the incremental value of biomarkers, including N-terminal prohormone of brain natriuretic peptide (NT-proBNP), high-sensitivity troponin T (hs-TnT), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), growth differentiation factor 15 (GDF-15), and procollagen type 1 N-terminal propeptide (P1NP), in predicting incident cardiovascular events and mortality among asympto

Disparities in pharmacotherapy for alcohol use disorder in the context of universal health care : A Swedish register study

Background and aims: Pharmacotherapy can be an important part of the continuum of care for alcohol use disorder (AUD). The Swedish universal health-care system emphasizes provision of care to marginalized groups. The primary aim was to test associations of neighborhood deprivation and disadvantaged social status with receipt of AUD pharmacotherapy in this context. Design: Data from linked populati

Changes in paraurethral connective tissue at menopause are counteracted by estrogen

OBJECTIVE: To study whether the transition to menopause is accompanied by changes in the paraurethral connective tissue and if these changes are modified by estrogen replacement therapy.STUDY DESIGN: Biopsies were obtained from the paraurethral tissue from 34 women; 12 menstruating, 14 postmenopausal without estrogen treatment, and 8 with estrogen treatment. Collagen concentration and collagen ext

Influence of naloxone infusion on analgesia and respiratory depression following epidural morphine.

The influence of two different concentrations of iv naloxone infusion on the analgesia and adverse effects of epidural morphine were compared in a double-blind, placebo-controlled study. Forty-five patients undergoing gallbladder surgery were provided postoperative analgesia by 4 mg epidural morphine; they then received an iv infusion over a 12-h period consisting of either 5 micrograms X kg-1 X h

Vasomotor symptoms, estradiol levels and cardiovascular risk profile in women.

OBJECTIVES: We investigated whether menopausal vasomotor symptoms (VMS) are related to an adverse cardiovascular risk profile. Furthermore, we examined the association between estradiol levels and VMS, and whether an association between VMS and cardiovascular risk factors can be explained by estradiol levels. STUDY DESIGN: We used data from a Swedish population-based sample of 5857 women, aged 50-