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Dysregulation of autophagy has been observed in obesity and type 2 diabetes. Salt-inducible kinase 2 (SIK2), a member of the AMPK-related kinase family, is downregulated in adipocytes from obese or insulin resistant individuals and was previously demonstrated to regulate autophagy in cancer and normal cell lines. The aim of this study was thus to investigate a potential role of SIK2 in the regulat
Aberrant epigenetic changes in DNA methylation and histone acetylation are hallmarks of most cancers, whereas histone methylation was previously considered to be irreversible and less versatile. Recently, several histone demethylases were identified catalyzing the removal of methyl groups from histone H3 lysine residues and thereby influencing gene expression. Neuroblastomas continue to remain a c
BACKGROUND: Gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) share many pathophysiological factors including genetics, but whether epigenetic marks are shared is unknown. We aimed to test whether a DNA methylation risk score (MRS) for T2DM was associated with GDM across ancestry and GDM criteria.METHODS: In two independent pregnancy cohorts, EPIPREG (n = 480) and EPIDG (n =
The kinin B1 receptor (B1R) is a G protein-coupled receptor with pro-inflammatory activity that is latent in healthy tissues but induced by tissue insult. Here, we investigated if B1R homo-oligomerization is a possible mechanism regulating the presentation of this receptor at the level of maturation and trafficking to the cell surface. To this end, we used HEK293 cells stably expressing N-terminal
Purpose: The purpose of this paper is to shed light on which role authenticity plays in mobile dating apps, an environment where users can present themselves only with a limited amount of information. By investigating how users create their profiles and evaluate others, the existing knowledge on authenticity and self-presentation can be advanced. Methodology: The research applied a relativist and
Incomplete reporting of microscopy methods undermines transparency, reproducibility, and data reuse. Despite recent initiatives, comprehensive, broadly endorsed, and accessible reporting guidelines are still lacking. Here, we present a bare minimal microscopy reporting requirements checklist that integrates human- and machine-readable input to provide clear, actionable guidance for researchers, re
Objectives: To investigate whether pancreatic steatosis is associated with the presence of pancreatic cysts among individuals with diabetes. Material and Methods: 158 individuals [mean age 66 ± 10 years, 81 (51%) female] with diabetes [135 (85%) had type 2 diabetes] participated in the study involving Magnetic Resonance Imaging (MRI), blood tests and anthropometric measurements. Pancreatic steatos
Microsoft Word - SASI03_2019_Study Guide Course requirements Attendance The course is comprised of lectures, seminars, labs and an excursion. Unless there are valid reasons to the contrary, participation is required in all components marked as “mandatory” in the schedule. Students who have been unable to participate due to circumstances such as accidents or sudden illness will be offered the oppor
https://www.lumes.lu.se/sites/lumes.lu.se/files/sasi03_study_guide_h19.pdf - 2026-07-21
Machine learning, alongside other branches of AI have entered an era of rapid growth in several industries including healthcare, creating vast opportunities to advance several aspects of clinical practice. Specific to clinical decision support, despite the immense potential benefits of incorporating machine learning into clinical decision support systems, also known as machine learning enabled cli
Popular Abstract in English The Andean region and the Amazon Basin of South America have been identified as regions of origin and the domestication of many plants. Some of the food crops from these regions such as potato and cassava, have gained global import¬ance, while the majority of food crops are hardly know outside their present area of cultivation. In the first part of this study, underutiBoth the nutritional and functional properties of starch are directly influenced by the molecular structure of its polymers: amylose and amylopectin. It is therefore important to have reproducible methods for quantifying the molecular size. In the first part of the thesis, the composition, crystallinity, degree of branching, morphological, thermal and pasting properties, and susceptibility of the
Background Anti-interleukin (IL)-4Rα monoclonal antibodies (mAb) improve lung function and decreasethe number of exacerbations in patients with COPD type (T) 2 inflammation. However, the involvement ofearly innate immune responses underlying these treatment effects is not well known. We sought tounderstand the effect and mechanisms of IL-4Rα mAb treatment on bronchial epithelial cells (BECs) fromCBackgroundAnti-IL-4Rα monoclonal antibodies (mAb) improve lung function and decrease the number of exacerbations in patients with COPD type (T) 2 inflammation. However, the involvement of early innate immune responses underlying these treatment effects is not well known. We sought to understand the effect and mechanisms of IL-4Rα mAb treatment on bronchial epithelial cells from COPD patients under
Centrum för miljö- och klimatforskning, CEC, Miljövenetskaplig Utbildning, Sölvegatan 37, 223 62 Lund http://www.miljovetenskap.lu.se/ MVEN06 - Miljöövervakning, 15p VT18 (Obs: alla tider med kvart!) Kurstid: - Kurschef: Adam Kristensson, tel:046-2227645, email: adam.kristensson@nuclear.lu.se Johan Hollander, tel:046-2223473, email: Johan.Hollander@biol.lu.se Lärare: Namn Email AKR Adam Kristensso
https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/schema_mven06_vt18_v5.1.pdf - 2026-07-21
Centrum för miljö- och klimatforskning, CEC, Miljövenetskaplig Utbildning, Sölvegatan 37, 223 62 Lund http://www.miljovetenskap.lu.se/ MVEN06 - Miljöövervakning, 15p VT18 (Obs: alla tider med kvart!) Kurstid: - Kurschef: Adam Kristensson, tel:046-2227645, email: adam.kristensson@nuclear.lu.se Johan Hollander, tel:046-2223473, email: Johan.Hollander@biol.lu.se Lärare: Namn Email AKR Adam Kristensso
https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/schema_mven06_vt2018_v4.pdf - 2026-07-21
Children spend a large percentage of their day with their classmates in school. Classmates are not only co-workers, but also individuals interacting socially as friends. The understanding of group affiliation and friendship interaction in school is of great importance to social work in school because of its implications on children’s wellbeing and academic performance. Several studies show that soChildren spend a large percentage of their day with their classmates in school. Classmates are not only co-workers, but also individuals interacting socially as friends. The understanding of group affiliation and friendship interaction in school is of great importance to social work in school because of its implications on children’s wellbeing and academic performance. Several studies show that so
