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Protein ADP-ribosylation is a reversible post-translational modification that regulates important cellular functions. The identification of modified proteins has proven challenging and has mainly been achieved via enrichment methodologies. Random mutagenesis was used here to develop an engineered Af1521 ADP-ribose binding macro domain protein with 1000-fold increased affinity towards ADP-ribose. T
We have characterized 2 distinct mechanisms through which infectious agents may promote platelet adhesion and thrombus formation in flowing blood, thus contributing to the progression of disease. In one case, the process initiates when the integrin alpha(IIb)beta(3) mediates platelet arrest onto immobilized bacterial constituents that have bound plasma fibrinogen. If blood contains antibodies agai
A simple and direct method based on hollow fibresupported liquid membrane (HFSLM) extraction and liquid chromatography equipped with a UV detector was developed for analysis and quantification of parabens in cosmetic products. The parabens analysed included methyl, ethyl, propyl, isobutyl and butyl paraben. The HFSLM extraction was carried out by employing di-n-hexyl ether as organic liquid that w
Popular Abstract in Undetermined The transparent wings of tiny parasitic wasps and small flies are remarkably thin, only a few hundreds nanometers thick, and may appear to have a simple structural airfoil design. The thesis deals with new findings about structural color reflections and the ultrastructure of such tiny transparent wings of parasitic wasps. The main discovery is that when seemingly tThe remarkably thin transparent wing membranes in tiny wasps may appear to have a simple structural design, but hide a largely unexplored complex of micro-morphological features that serve aerodynamics and may also function in visual signaling. I found that when such small transparent wings are viewed against a dark background they display vivid structural color patterns due to thin film interfere
EndoS from Streptococcus pyogenes efficiently hydrolyzes the functionally important and conserved N-linked glycan of IgG in human blood. Repeated i.v. administration of EndoS in rabbits completely hydrolyzes the glycans of the whole IgG pool, despite the generation of anti-EndoS antibodies. EndoS administration had no apparent effects on the health of the animals. EndoS hydrolysis of the IgG glyca
Group B Streptococcus (GBS) is a leading cause of invasive bacterial infections in human newborns. A key GBS virulence factor is its capsular polysaccharide (CPS), displaying terminal sialic acid (Sia) residues which block deposition and activation of complement on the bacterial surface. We recently demonstrated that GBS Sia can bind human CD33-related Sia-recognizing immunoglobulin (Ig) superfami
Angiogenesis is a hallmark of cancer and is now a validated therapeutic target in the clinical setting. Despite the initial success, anti-angiogenic compounds impinging on the vascular endothelial growth factor (VEGF) pathway display limited survival benefits in patients and resistance often develops due to activation of alternative pathways. Thus, finding and validating new targets is highly warr
Lund University Course (e LUMES Master Thesis 2002/2003 Yan Borne’ The Environmental Impacts of the Olympic Games— Looking Forward to the Olympic Games 2008 in Beijing, China "The only environmentally sound Olympics would be no Olympics at all.” ---- Olav Myrholt, the Olympic project leader for the Norwegian Society for Conservation of Nature. By Yan Borne’ Supervisor Stefan Anderberg Master Thesi
https://www.lumes.lu.se/sites/lumes.lu.se/files/borne_yan.pdf - 2026-07-17
Context:The adoption or acceptance of new technologies or ways of working in software development activities is a recurrent topic in the software engineering literature. The topic has, therefore, been empirically investigated extensively. It is, however, unclear which theoretical frames of reference are used in this research to explain acceptance behaviors.Objective:In this study, we explore how mContext:The adoption or acceptance of new technologies or ways of working in software development activities is a recurrent topic in the software engineering literature. The topic has, therefore, been empirically investigated extensively. It is, however, unclear which theoretical frames of reference are used in this research to explain acceptance behaviors.Objective:In this study, we explore how m
Expansions of innovation policies have been paralleled with an increase in the evaluations of such policies. Yet, there are few systematic evaluations of how such evaluations are conducted, by whom, and their overall conclusions. We analyze 110 evaluations of innovation policy in Sweden from 2005 to 2019. Our findings show that the majority of these evaluations are positive, about one-third are neExpansions of innovation policies have been paralleled with an increasein the evaluations of such policies. Yet, there are few systematic evaluations of how such evaluations are conducted, by whom, and their overall conclusions. We analyze 110 evaluations of innovation policy in Sweden from 2005 to 2019. Our findings show that the majority of these evaluations are positive, about one-third are neu
This is the first multi-district Standardised Patient (SP) study in South Africa. It measures the quality of TB screening at primary healthcare (PHC) facilities. We hypothesise that TB screening protocols and best practices are poorly adhered to at the PHC level. The SP method allows researchers to observe how healthcare providers identify, test and advise presumptive TB patients, and whether thisThis is the first multi-district Standardised Patient (SP) study in South Africa. It measures the quality of TB screening at primary healthcare (PHC) facilities. We hypothesise that TB screening protocols and best practices are poorly adhered to at the PHC level. The SP method allows researchers to observe how healthcare providers identify, test and advise presumptive TB patients, and whether this
Namnlös Program för Nationellt möte 26:e september Dalheimers hus Göteborg Sjukdomens påverkan på familjen! 8.30 Registrering och kaffe 9.00 Introduktion - Vad innebär det att ha Huntingtons sjukdom i familjen? Film och reflektioner från personer med sjukdom, anhöriga och personal. Carina Hvalstedt, moderator och Annette Carlsson, ordförande, Riksförbundet Huntingtons sjukdom (RHS) 9.45 Forsknings
Postadress: Box 117, 221 00 Lund Besöksadress: Sandgatan 13A, Gamla Kirurgen, 223 50 Lund Telefon: 046-222 00 00 Fax: 046-222 44 11 E-post: info@sam.lu.se Webbadress: www.sam.lu.se Ett universitet i världsklass som förstår, förklarar och förbättrar vår värld och människors villkor. Strategi för Samhällsvetenskapliga fakulteten 2021–2026 Fakulteten ska attrahera och behålla engagerade studenter och
https://www.sam.lu.se/internt/sites/sam.lu.se.internt/files/2021-02/strategi_for_sfak_2021-26.pdf - 2026-07-17
Popular Abstract in English An increased risk of pre-cancer lesions of the cervix among HIV-infected women, and the positive impact of HIV treatment on its outcome has been reported globally. However there is paucity of information from west Africa with genetically distinct viral strains. Considering that HIV strains differ in the rate and pattern of HIV disease progression, a different outcome isBackground: The highest numbers of HIV-infected women are in sub- Saharan Africa, where the natural progression of HIV disease in the absence of treatment results in death before the onset of invasive cervical cancer. With improved access to treatment, several studies outside West Africa demonstrated an increased risk of pre-invasive cervical lesions among HIV-infected women and the positive impac
Nonsense-mediated mRNA decay (NMD) is a post-transcriptional surveillance process that eliminates mRNAs containing premature termination codons (PTCs). NMD has been hypothesized to impact on several aspects of cellular function; however, its importance in the context of a mammalian organism has not been addressed in detail. Here we use mouse genetics to demonstrate that hematopoietic-specific dele
The tear opening study is conducted with an example from the Tetra Pak package industry, the Tetra Top package. The top of the package is constructed by a injection molded low density thermoplastic. The package is opened with a tear opening located on the top part. In order to make tear opening more versatile, studies how opening forces reacts upon material modifications and alternative geometry h
