Filetype
BACKGROUND AND PURPOSE: Treatment of cancer with immune checkpoint inhibitors (ICIs) entails a risk of immune-related adverse events (irAEs). Data on the treatment of immune-related enterocolitis (irEC) in patients with inadequate symptom control after treatment with standard therapy including corticosteroids, infliximab, and vedolizumab are scarce. Based on limited data, recommendations include t
Background: Intra- and interfractional variations in anatomy can cause unplanned substantial alterations of the dose distribution of the target in proton therapy. Motion management methods might be used in order to minimize anatomical variations. In the proton therapy of lung cancer, a potential motion management technique is the use of the voluntary breath-hold approach. The aim of this study was
Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are becoming an increasingly global concern. PFASs are highly fluorinated organic chemicals that represent a serious risk for environmental and human health. Due to their toxicological impact, PFASs are now included in several emission regulations. Even if the global level of PFASs use is decreasing much of present concentrations in the environ
The modern use of neoadjuvant and conversion systemic therapy in patients with colorectal cancer liver metastasis (CRLM) has improved resection rates and changed the borders between “resectable” and “unresectable” disease. Also, the use of preoperative systemic therapy has resulted in an increased frequency of disappearing liver metastasis (DLM). The optimal management of DLM is still controversia
Introduction: Investigation of bone marrow (BM) trephine biopsies and/or clot sections by CD34 immunohistochemistry (IHC) testing has been used by pathologists for several decades, and its clinical value has been well established with QBEND10 being the most frequently used primary antibody (Ab) clone. However, most other parameters related to the IHC protocol as well as the readout vary widely bet
Interdisciplinary research and education on human-environment relations has a natural place in many Anglo-American geography and anthropology departments. In Sweden, however, critical scholarship across the socio-natural divide has largely been outsourced to the interdisciplinary field of human ecology. Since the 1970s, Swedish human ecologists have sought to integrate perspectives from the social
An experimentally based prediction model of road abrasion wear due to studded tyres is available in Sweden and has been found to work well. However, it has not been validated since 2007, and since then road surfaces and tyre design have developed, and the question has arisen regarding the model’s current validity. The abrasion wear model is used in the NORTRIP emission model (NOn-exhaust Road Traf
Due to advances in technology, sampling procedures and short lag times between successive sampling, autocorrelation among the measured data has become common in most applications. Neglecting autocorrelation leads to a poor false alarm performance. In the current paper, the effect of the autocorrelation on the performance of a variable-parameters multivariate single control chart is investigated in
Variable parameters (VP) schemes are the most effective adaptive schemes in increasing control charts' sensitivity to detect small to moderate shift sizes. In this paper, we develop four VP adaptive memory-type control charts to monitor multivariate multiple linear regression profiles. All the proposed control charts are single-chart (single-statistic) control charts, two use a Max operator and tw
In the plant-based beverage industry, a residue called okara, is generated in large quantities in the liquid-solid separation step. Despite the high nutritional value of okara from soy and oat beverages with respect to fiber and protein content, these residues are generally discarded or used as animal feed or compost. It would be more sustainable to utilize okara for human consumption, however, th
BACKGROUND: Recent advances now allow detection of brain-specific proteins in blood, including neurofilament light chain (NfL), a marker of axonal pathology, and glial fibrillary acidic protein (GFAP), indicative of astrocytic activation. Given the evidence of astroglial pathology and neuronal dysfunction in bipolar disorder, and ongoing debates on neuroprogression, we investigated plasma NfL and
PurposeThe purpose is to increase the understanding of when a heritage in the non-profit category becomes a part of the established heritage sector, and how this can be understood with regard to the rising awareness of climate change in heritage management and recent theories within the field. The case is Hindås Ski Jumping Hill in Hindås, Sweden, which since 2022 is a listed building in Sweden.De
Taboo obsessions are ego-dystonic, recurrent, and intrusive thoughts involving aggressive, sexual and/or religious themes, which are common in individuals with obsessive-compulsive disorder (OCD). These symptoms are often challenging to treat with traditional, exposure-based approaches. Our research group has developed and successfully piloted an Internet-delivered intervention based on the cognit
A series of Na0.67Ni0.33Mn0.67-xSnxO2 (x = 0, 0.01, 0.03, 0.05) materials with mixed P2/P3 phases are synthesized with a conventional solid-state reaction method and investigated as cathode materials for sodium ion batteries. The effects of Sn substitution on the structure and electrochemical performance of the Na0.67Ni0.33Mn0.67O2 are systematically investigated. The substituted samples show smal
Nocturia, the urge to wake from sleep to void, is targeted sub-optimally by existing drugs that modulate circadian dysregulation of urine production in kidney without alleviating detrusor overactivity, a key aspect in the multifactorial etiology of nocturia. This study reports age-related upregulation of arginine vasopressin (AVP) synthesis in mouse urinary bladder to counter the concurrent declin
