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Objective: To assess the effects of a 6-month angiotensin-converting enzyme (ACE) inhibitor intervention on myocardial ischaemia.Method: We randomized 389 patients with stable coronary artery disease to double-blind treatment with ramipril 5 mg/day (n = 133), ramipril 1.25 mg/day (n = 133), or placebo (n = 123). Forty-eight-hour ambulatory electrocardiography was performed at baseline, and after 1

The inner relative humidity (RH) and degree of saturation (S) of high-performance concrete cured for 2 years in water or 3% NaCl solution were measured at three different levels from the concrete surface (outer layer 0 to 16 mm, middle layer 16 to 32 mm, and inner layer 32 to 50 mm). The effects of many factors, such as water-to-cement (w/c) ratio, content of silica fume, and air content, were inv

Health-health analysis (HHA) focuses on statistical lives themselves as a numeraire. The underlying principle is that the expected gains in health and safety of reduced risks in one area may result in increasing risks somewhere else in society. By reducing one risk other risks may increase due to changed individual behaviour. In addition to this direct effect, another indirect effect will also be

The aim of this study was to investigate determinants of help from informal or formal caregivers or a combination of both among people aged 75 or more and living at home, and the characteristics of the recipients, the help they received and their quality of life (QoL). The sample for this study was 448 elderly people, 75-99 years of age, living at home and receiving help with activities for daily

Background: Upper limb disorders (ULDs) are common, and so are the difficulties in specific diagnoses of these disorders. Prior studies have shed light on the nerves in the diagnostic approach beside disorders related to muscles, tendons and joints (MCDs). Objective: The study aimed to compare the distribution of upper limb disorders, and the vibration perception threshold (VPT) in different diagn

Pain is a common problem for older persons who need professional help for their daily living. In this study 94 older persons (75+) in persistent pain were compared with 52 care providers concerning the pain management methods they had used/administered during the previous week and how helpful they perceived these methods to be. interviews were based on 16 items from the original version of the pai

Oscillator strengths for selected transitions of Sr II and Y III have been determined using ab initio multiconfiguration Hartree-Fock techniques. The importance of including an accurate treatment of the core-valence correlation is emphasized. The results are used to determine the abundances of Sr and Y in the chemically peculiar star chi Lupi from HST/GHRS Echelle spectra. Overabundances of 2.09 d

Vacuum-assisted wound closure (VAC) therapy may heal wounds faster than conventional dressings after surgical debridement of perivascular groin infections after vascular surgery.

In systemic sclerosis (SSc)-related interstitial lung disease (ILD), elevated eosinophil counts in bronchoalveolar lavage are associated with a worse outcome. We hypothesized that eosinophils may be activated in the peripheral circulation, thereby increasing their recruitment to affected tissues and contributing to inflammation and fibrosis. The aim of this study was to characterize the blood eosi

A search is presented for heavy-quark pair production (Q (Q) over bar) under the decay hypothesis Q (Q) over bar -> W(+)qW(-)(q) over bar with q = d, s, b for up-type Q or q = u, c for down-type Q. The search is performed with 1.04 fb(-1) of integrated luminosity from pp collisions at root s = 7 TeV collected by the ATLAS detector at the CERN LHC. Dilepton final states are selected, requiring larg

Four randomized studies show that adjuvant radiotherapy (RT) lowers the risk of subsequent ipsilateral breast events (IBEs) after breast-conserving surgery (BCS) for ductal carcinoma in situ (DCIS) by approximately 50% after 10 to 15 years. We present 20 years of follow-up data for the SweDCIS trial.

The aim of this study was 1) to investigate interfraction set-up uncertainties for patients treated with respiratory gating for left-sided breast cancer, 2) to investigate the effect of the inter-fraction set-up on the absorbed dose-distribution for the target and organs at risk (OARs) and 3) optimize the set-up correction strategy. By acquiring multiple set-up images the systematic set-up deviati

Abundant peptides and proteins containing arginine (Arg) and lysine (Lys) amino acids can apparently permeate cell membranes with ease. However, the mechanisms by which these peptides and proteins succeed in traversing the free energy barrier imposed by cell membranes remain largely unestablished. Precise thermodynamic studies (both theoretical and experimental) on the interactions of Arg and Lys

Agricultural productivity in East African smallholder systems is notoriously low and food production faces multiple challenges, including soil degradation, decreasing land availability, poor market integration, disease burdens and climate change impacts. However, recent evidence from an in-depth study from two sites in Kenya and Uganda shows signs of new social dynamics as a response to these mult

Background Hepatic veno-occlusive disease is a leading cause of morbidity and mortality after haemopoietic stem-cell transplantation (HSCT). We aimed to assess whether defibrotide can reduce the incidence of veno-occlusive disease in this setting. Methods In our phase 3 open-label, randomised controlled trial, we enrolled patients at 28 European university hospitals or academic medical centres. El

A simple mass balance model has been developed to assess the planetary boundary for P supply in relation to use by human society. Phosphorus sources used by humans are from fossil reserves. The model takes into account resource use rate and reserves, consumption, phosphate to food production, environmental degradation, waste and recycling. Various policy scenarios are tested from current end of pi