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Background: Administration of various exogenous surfactant preparations has been shown to decrease lung injury and pneumothorax and improve survival in very preterm infants with respiratory distress syndrome (RDS). There is no consensus on the threshold for surfactant administration, to allow timely intervention and avoid over-treatment, also considering the invasiveness of the procedure and its c
Seismic Structural Health Monitoring (S2HM) provides information about the integrity of civil structures and infrastructure in the aftermath of an earthquake. However, quantifying the benefits of S2HM information is crucial to justify the investment in S2HM systems. The benefit of S2HM can be computed through the Value of Information (VoI) from Bayesian decision theory, which compares the expected
Purpose: Linked health-care registries and high coverage in Nordic countries lend themselves well to epidemiologic research. Given its relatively high incidence in Western Europe, complexity in diagnosis, and challenges in registration, multiple myeloma (MM) wasselected to compare registries in Denmark, Finland, and Sweden.Patients and Methods: Data were obtained from four archetypal registries in
This study investigates people’s associations between the exchange of sexual services for payment and different sexual activities. Sex work entails a range of activities, from in person services to online performances. To date, no study has asked about the activities individuals associate with the exchange of sexual services for payment. The relationship between the exchange of sexual services for
Background: A growing evidence base supports the use of autologous haematopoietic stem cell transplantation (aHSCT) for treatment of relapsing-remitting multiple sclerosis (RRMS), but it has not yet been integrated into most national clinical guidelines. The objective of this study was to assess efficacy and safety when aHSCT is implemented in routine healthcare. Methods: We assessed 231 patients
A search for vector-like leptons in multilepton (two, three, or four-or-more electrons plus muons) final states with zero or more hadronic τ-lepton decays is presented. The search is performed using a dataset corresponding to an integrated luminosity of 139 fb−1 of proton-proton collisions at a centre-of-mass energy of 13 TeV recorded by the ATLAS detector at the LHC. To maximize the separation of
Public discourse and political climate policymaking are based on scientific reports and propose technological solutions to solve the crisis, primarily by changing fossil fuels to renewable energy. Rather than questioning growth and the overuse of natural resources—which has been at the core of green concern for decades—green growth is the motor in an economy that aims for continuous economic spin,
Cetuximab is an epidermal growth factor receptor (EGFR)-targeting drug that has shown effects in head and neck squamous cell carcinoma (HNSCC). The effects are, however, small and have mainly been proven in a subset of patients, and the cost-effectiveness has been questioned. For this reason, we need to know more about the basic mechanisms controlling the effect of EGFR signalling on tumour growth
Larger amounts of variable renewable energy sources bring about larger amounts of uncertainty in the form of forecast errors. When taking operational and planning decisions under uncertainty, a tradeoff between risk and costs must be made. Today's deterministic operational tools, such as N-1-based methods, cannot directly account for the underlying risk due to uncertainties. Instead, several defin
Incorporation of nanoscale catalysts into porous structures of SOFC has been proven highly successful in increasing active sites and catalyst utilization. In addition, electrochemical reactions as well as heat transfer process in porous anode are strongly affected by complex porous structures. It is believed that study of anode thermal properties are critical for SOFC design and operation. In this
This study was initiated to analyze the effect of increased snow cover on plant photosynthesis in subarctic mires underlain by permafrost. Snow fences were used to increase the accumulation of snow on a subarctic permafrost mire in northern Sweden. By measuring reflected photosynthetic active radiation (PAR) the effect of snow thickness and associated delay of the start of the growing season was a
Granulocyte colony-stimulating factor (G-CSF; AX200; Filgrastim) is a stroke drug candidate with excellent preclinical evidence for efficacy. A previous phase IIa dose-escalation study suggested potential efficacy in humans. The present large phase IIb trial was powered to detect clinical efficacy in acute ischemic stroke patients.
The frequency-modulated continuous-wave (FMCW) technique, based on the beat signal of a Mach– Zehnder interferometer employing a frequency-ramped light source, is studied for solid scattering media applications. The method is used to evaluate the mean time-of-flight (MTOF) of light traveling in scattering media, specifically polystyrene foams. We assume that each the time-of-flight (TOF) time corr
Intraspecific variation in seed size may result from life-history constraints or environmental conditions experienced. This variation in seed size is likely to affect the early stage of invasion as seed size may contribute to the success or failure of population establishment. However, only a few studies have examined seed size variability and its causes and consequences for invaders so far. Using
This paper presents a new strategy to combine the power of antibody based capturing of target species in complex samples with the benefits of microfluidic reverse phase sample preparation on an integrated sample enrichment target (RP-ISET) and the analysis speed of MALDI MS. The immunoaffinity step is performed on an in-house developed 3D-structured high surface area porous silicon (PSi) matrix, w
Physical exercise during growth affects composition, structure and mechanical properties of bone. In this study we investigated whether the beneficial effects of exercise during the early growth phase have long-lasting effects or not. Female Syrian golden hamsters (total n=152) were used in this study. Half of the hamsters had access to running wheels during their rapid growth phase (from 1 to 3mo
A pioneer study of the previously unknown delta C-13 chemostratigraphy in the Ordovician/Silurian boundary interval in eastern Iowa and northeastern Illinois resulted in the discovery of the Hirnantian Isotope Carbon Excursion (HICE). The presence of this major isotope excursion in the Mosalem Formation in Iowa and the Wilhelmi Formation in Illinois, which indicates that the excursion interval in
The aim of this study was to investigate how patients perceive information and their health-related quality of life 1 month after discharge for colorectal cancer surgery. The aim was also to compare these results with the first 2 weeks at home and to identify factors related to the perception of information. One hundred patients from three surgical clinics in the south of Sweden were included in t
A major goal in evolutionary biology is to determine how phenotypic variation arises and is maintained in natural populations. Recent studies examining the morphological, physiological and behavioural differences among discrete colour morphotypes (morphs) have revealed several mechanisms that maintain discrete variation within populations, including frequency-dependence, density-dependence and cor
