Search results

The perception of breathlessness is mechanistically linked to the awareness of increased inspiratory neural drive (IND). Stimulation of upper airway cold receptors on the trigeminal nerve (TGN) with TGN agonists such as menthol or cool air to the face/nose has been hypothesized to reduce breathlessness by decreasing IND. The aim of this systematic scoping review was to identify and summarize the r

Ulva rigida is a widely available marine algae representing a valuable biomass from which natural photosensitizers (chlorophylls) can be obtained in an environmentally friendly manner using a green microwave-assisted extraction technique. If properly loaded in biocompatible nanoformulations, such highly hydrophobic chlorophylls with photosensitizing activity may constitute effective drugs useful i

The presence of microplastics (MPs) in water represents a current problem for marine life and a future serious issue for human health. This is pushing towards new approaches for the removal of MPs and, hence, their characterization and evaluation, which up to now has represented a limit for tentative procedures for their degradation. Herein, we reported on a new facile, in situ and non-destructive

Direct reprogramming of somatic cells into neurons offers a promising strategy for studying neurological disorders and developing cell-based therapies. This protocol describes the 3D direct reprogramming of human glial progenitor cells into dopaminergic neurons. It includes spheroid formation, lentiviral transduction, neuronal induction using doxycycline, and validation via gene expression and imm

We present a wall-to-wall map of dominant tree species in Swedish forests accompanied by pixel-level uncertainty estimates. The tree species classification is based on spatiotemporal metrics derived from Sentinel-1 and Sentinel-2 satellite data, combined with field observations from the Swedish National Forest Inventory and auxiliary data on geomorphometry and canopy height. We apply an extreme g

Label-free chemical imaging of living and functioning systems is the holy grail of biochemical research. However, existing techniques often require extensive sample preparation to remove interfering molecules such as water, rendering many molecular imaging techniques unsuitable for in situ structural studies. Here, we examined freshly extracted tissue biopsies and living small vertebrates at submi

In a world where the challenges of climate change, social inequality, economic instability, and geopolitical tensions are ever-present, educators have a unique opportunity—and responsibility—to prepare their students to navigate these complexities. However, educators are also juggling teaching and research, competing deadlines, shifting expectations, institutional paradigms, and limited time and s

Introduction: Familial risk of lung cancer (LC) is at the level of many common cancers (ca 2.0) but as cigarette smoking is the main cause of LC, it has remained undefined to what extent smoking contributes to the familial risk. We take advantage of the natural experiment of divorce. In Sweden, it has been customary that children stay with their mother after divorce. We thus hypothesize that only

Nanoplastics are emerging environmental contaminants that increasingly threaten soil ecosystems, yet their effects on microbial behavior remain poorly understood. This is mainly due to the lack of experimental tools capable of directly observing microbial dynamics in situ under realistic soil-like conditions. Here, we present a proof-of-concept system that enables real-time, high-throughput monito

BACKGROUND: Children with autism spectrum disorder (ASD) are at increased risk of epilepsy (EP), but distinguishing epileptic seizures from ASD-associated behavior remains a clinical challenge. Although previous studies have reported changes in peripheral immune markers in adults with EP, it remains unclear whether similar immune signatures are present in pediatric patients with both ASD and EP, a

AIMS: Vascular atherosclerotic calcification is a pathological process marked by the abnormal deposition of calcium minerals in the intima. Asporin (ASPN) is a small leucine-rich proteoglycan which interacts with collagen and calcium. Due to its role in matrix mineralization, we hypothesized that ASPN might act as a regulator of vascular calcification, thereby promoting atherosclerotic plaque stab

Background: Nocturnal hypoxemia commonly affects people with pulmonary fibrosis (PF). Research Question: What are the current practices for assessment of sleep and nocturnal hypoxemia in PF, and what are the research priorities and outcome measures of importance for nocturnal oxygen therapy (NOT)? Study Design and Methods: People with PF and health care professionals (HCPs) with expertise in PF, s

The present work describes the formation of low-aspect-ratio Ag nanoparticles (NPs) arrays by sequential deposition of Ag from different growth directions on a nanoripple-patterned Si substrate, produced by low-energy ion beam irradiation. It is observed that the growth of Ag-NPs on ripple surfaces is direction-dependent due to the asymmetric ridge of the ripple pattern. This asymmetric ridge can

Quasi-two dimensional (2D) perovskites have emerged as a promising class of materials due to their remarkable photoluminescence efficiency, which stems from their exceptionally high exciton binding energies. The spatial confinement of excitons within smaller grain sizes could enhance the formation of biexcitons leading to higher radiative recombination efficiency. However, the synthesis of high-qu