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The bonding of glass substrates is an important process in the fabrication of glass micro/nanofluidic devices. In this study, the influence of the surface roughness of glass substrates after low-temperature bonding is investigated. It is found that plasma etching can be used to control the surface roughness to the range 2-9 nm. Substrates with a roughness of 5 nm or less can be bonded. The pressur

Background: Antibody-based immunoassays have enabled quantification of very low concentrations of phosphorylated tau (p-tau) protein forms in cerebrospinal fluid (CSF), aiding in the diagnosis of AD. Mass spectrometry enables absolute quantification of multiple p-tau variants within a single run. The goal of this study was to compare the performance of mass spectrometry assessments of p-tau181, p-

A fundamental issue in the metabolic field is whether it is possible to understand underlying mechanisms that characterize individual variation. Whole-animal performance relies on mitochondrial function as it produces energy for cellular processes. However, our lack of longitudinal measures to evaluate how mitochondrial function can change within and among individuals and with environmental contex

RATIONAL: The human perirhinal cortex (PRC) plays critical roles in episodic and semantic memory and visual perception. The PRC consists of Brodmann areas 35 and 36 (BA35, BA36). In Alzheimer's disease (AD), BA35 is the first cortical site affected by neurofibrillary tangle pathology, which is closely linked to neural injury in AD. Large anatomical variability, manifested in the form of different

Considerable time is often spent optimizing antennas to meet specific design metrics. Rarely, however, are the resulting antenna designs compared to rigorous physical bounds on those metrics. Here, we study the performance of optimized planar meander line antennas with respect to such bounds. Results show that these simple structures meet the lower bound on the radiation quality factor (Q-factor)

In this narrative review, we survey recent empirical evaluations of AI-based language assessments and present a case for the technology of large language models to be poised for changing standardized psychological assessment. Artificial intelligence has been undergoing a purported “paradigm shift” initiated by new machine learning models, large language models (e.g., BERT, LAMMA, and that behind C

To limit global warming to 1.5°C, fossil fuel use must rapidly decline, but historical precedents for such large-scale transitions are lacking. Here we identify 147 historical episodes and policy pledges of fossil fuel decline in 105 countries and global regions between 1960 and 2018. We analyze 43 cases in larger systems most relevant to climate scenarios. One-half of 1.5°C-compatible scenarios e

Critical infrastructures (CIs) and the services they provide are imperative for the functioning of societies. CI safety and security have historically been addressed and regulated on a sectoral basis, despite their interdependent nature. These silo-structures potentially hinder achieving resilience from a system-of-systems governance perspective. Cross-sectoral initiatives addressing interdependen

The possibility to investigate complex magnetic profiles throughout an ultrathin magnetic film or an interface by soft x-ray resonant magnetic reflectivity is presented. The determination of in- and out-of-plane magnetic profile is shown to be possible with a subnanometer resolution by measuring the reflectivity over a wide angular range. The technique is applied to a granular magnetic multilayer

As part of the IEA-SHC Task 41 'Solar Energy and Architecture' an international survey was carried out. This paper presents its results for Subtask B which especially focuses on methods and tools for solar design applied by architects. Building professionals, mainly architects, were contacted via email and asked to participate in a web-based questionnaire about their use of methods and tools for s

Caused by SARS-CoV-2, COVID-19 has become a severe threaten to society and human health, its epidemic control emerges as long-term issue. A sustainable epidemic and environmental transmission risk control (SEERC) in urban area is urgently needed. This work aims to conduct a new investigation on the transmission risk of SARS-COV-2 as virus/hazardous material through various environmental medias, ro