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Inflammatory responses to acute stimuli are proposed to regulate sleep, but the relationship between chronic inflammation and habitual sleep duration is elusive. Here, we study this relation using genetically predicted level of chronic inflammation, indexed by CRP and IL6 signaling, and self-reported sleep duration. By Mendelian randomization analysis, we show that elevated CRP level within <10 mg
BACKGROUND AND OBJECTIVES: Reproductive-aged women are at an increased risk of developing iron deficiency (ID). We aimed to develop a non-invasive screening tool to identify ID in women and assess the acceptability of screening.STUDY DESIGN AND METHODS: We screened women (age 18-49 years) in the community of Western Australia.PRIMARY OUTCOME: acceptability of screening, assessed by the feasibility
Co-pathology is a common feature of neurodegenerative diseases that complicates diagnosis, treatment and clinical management. However, sensitive, specific and scalable biomarkers for in vivo pathological diagnosis are not available for most neurodegenerative neuropathologies. Here, we present ProtAIDe-Dx, a deep joint-learning model trained on 17,170 patients and controls that uses plasma proteomi
The transcriptional mechanisms underlying tooth development are only beginning to be understood. Pitx2, a bicoid-like homeodomain transcription factor, is the first transcriptional marker observed during tooth development. Because Pitx2, Msx2, and Dlx2 are expressed in the dental epithelium, we examined the transcriptional activity of PITX2 in concert with Msx2 and the Dlx2 promoter. PITX2 activat
T helper 17 (T H17) cells located at the Peyer's patch (PP) inductive site and at the lamina propria effector site of the intestinal immune system are responsive to both pathogenic and commensal bacteria. Their plasticity to convert into follicular helper T (T FH) cells has been proposed to be central to gut immunoglobulin A (IgA) responses. Here, we used an IL-17A fate reporter mouse and an MHC
What difference can local participation make in a world where inequality increases everywhere, where segregation pulls communities apart and where policymakers marginalise the needs and interests of the people whose lives their decisions affect the most? This question was central two decades ago when research on participatory institutions took off. Leftist scholars described participatory budgetinWhat difference can local participation make in a world where inequality increases everywhere, where segregation pulls communities apart and where policymakers marginalise the needs and interests of the people whose lives their decisions affect the most? This question was central two decades ago when research on participatory institutions took off. Leftist scholars described participatory budgetin
The microbial use of resources to sustain life and reproduce influences for example, decomposition and plant nutrient provisioning. The study of “limiting factors” has shed light on the interaction between plants and their environment. Here, we investigated whether carbon (C), nitrogen (N), or phosphorus (P) was limiting for soil microorganisms in a subarctic tundra heath, and how changes in resou
Advanced Parkinson's disease (PD) is characterized by motor fluctuations including unpredictable oscillations remarkably impairing quality of life. Effective management and development of novel therapies for these response fluctuations largely depend on clinical rating instruments such as the widely-used PD home diary, which are associated with biases and errors. Recent advancements in digital hea
Self-assembly gold nanostructured membranes are created to mechanically stabilize the catalyst movement during metal assisted chemical etching. This results in an improved vertical control of the etching profile for high aspect ratio silicon microstructures. The new method is a robust and cheap microfabrication for dense micro-patterns on a large area, such as diffraction gratings for hard X-ray p
Introduction: People living with acromegaly and neuroendocrine tumours (NETs) may be treated with injectable somatostatin receptor ligands (SRLs), administered by either a caregiver or as self-injection via a proprietary or generic device. Injection device attributes that contribute to ease of use and storage, minimise preparation requirements, and reduce injection pain are associated with improve
Internationella relationer har under 1900-talet utvecklats till en disciplin med en mängd teorier som för fram konkurrerande förklaringar till hur den internationella politiken fungerar. Trots det förs politiska partiers roll i skapandet av utrikespolitik sällan eller aldrig fram i litteraturen. Den här uppsatsen undersöker partipolitikens konsekvenser för de skandinaviska ländernas utrikespolitik
Denna framställning redogör för regleringen ekonomiskt bistånd enligt SoL, och hur rätten till bistånd för en individ kan påverkas av dennes anhöriga. En individ kan nekas ekonomiskt bistånd i de fall då de sammanlever med en make, maka eller sambo som har tillräckliga ekonomiska tillgångar. Regleringen bygger således på en gränsdragning av biståndsrätten som innebär att familjen behandlas som en
I rättsväsendet är djur att betrakta som saker och egendom. Detta medför att djur, när de är brottsoffer, inte får samma skydd som människor i samma situation. Syftet med denna uppsats har varit att undersöka djurskyddet för häst i Sverige samt den samhälleliga synen på hästen för att se hur väl dessa överensstämmer med det faktum att hästen är att betrakta som en sak i vårt rättssystem. Djurplåg
I mer än 40 år har det pågått en diskussion om huruvida EU kan och bör ansluta sig till den Europeiska konventionen om skydd för de mänskliga rättigheterna och de grundläggande friheterna, (EKMR, konventionen). Efter Lissabonfördragets ikraftträdande finns numera till och med en fördragsstadgad skyldighet för unionen att ansluta sig till konventionen. Av den anledningen förhandlade EU-kommissionen
Inom svensk företagsbeskattning gäller principen om beskattningsårets slutenhet, vilken innebär att beräkningen av ett företags resultat som utgångspunkt ska avgränsas till den perioden. Det har länge funnits möjlighet att göra avsteg från principen genom förlustutjämning mellan år. En sådan möjlighet innebär att en förlust som uppkommer vid beräkning av den skattepliktiga inkomsten ett år får räkSwedish company taxation is based on a principle implying that the fiscal year is closed, which means that the calculation of a company’s result shall be limited to that period of time. For long, there have been possibilities to make deviations from this principle through loss equalization between years. Such a possibility means that a loss arising one fiscal year after calculating the taxable inc
This paper discusses a Python interface for the recently published Dune-Fem-DG module which provides highly efficient implementations of the discontinuous Galerkin (DG) method for solving a wide range of nonlinear partial differential equations (PDEs). Although the C++ interfaces of Dune-Fem-DG are highly flexible and customizable, a solid knowledge of C++ is necessary to make use of this powerful
Scholars and policy makers have intensely debated institutional reforms of the United Nations (UN) since its creation. Yet, relatively little attention has been given to institutional design preferences among the public in UN member states. This study examines two questions: Which possible rules concerning UN authority and representation do citizens prefer? Which personal and country characteristi
Oat (Avena sativa L.) is an important and nutritious cereal crop, and there is a growing need to identify genes that contribute to improved oat varieties. Here we utilize a newly sequenced and annotated oat reference genome to locate and characterize quantitative trait loci (QTLs) affecting agronomic and grain-quality traits in five oat populations. We find strong and significant associations betw
This study explores the experiences of Swedish upper secondary school chemistry students working with a socioscientific issue about per- and polyfluoroalkyl substances (PFAS) in everyday products, and how they perceive that this teaching has influenced them in their role as citizens in a democratic society. Data collection has been carried out on several occasions over a period of one and a half y
