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Gas6 and protein S are two homologous secreted proteins that depend on vitamin K for their execution of a range of biological functions. A discrete subset of these functions is mediated through their binding to and activation of the receptor tyrosine kinases Axl, Sky and Mer. Furthermore, a hallmark of the Gas6-Axl system is the unique ability of Gas6 and protein S to tether their non receptor-bin
Deviations from classical two-state kinetics in protein folding need not always be explained by the presence of rapidly formed intermediates. In some cases, such deviations are caused by short-lived aggregates whereas in other cases they arise from changes of the position of the transition state. These are two new facets of the mechanism of two-state folding. The first part of this account describ
A new concept for the preparation of selective sorbents with high flow path properties is presented by embedding molecularly imprinted polymers (MIPs) into various macroporous gels (MGs). A MIP was first synthetized with 17β-estradiol (E2) as template for the selective adsorption of this endocrine disrupter. The composite macroporous gel/MIP (MG/MIP) monoliths were then prepared at subzero tempera
Aims: Many lymphoma patients have both macroscopic tumors and single-cell manifestations of their disease. Treatment efficacy could, therefore, depend on the radionuclide used. The aim of this study was to investigate dosimetry at a cellular level for three isotopes of radioiodine. Methods: Cells were assumed to be spherical with radii of 6.35, 7.7, and 9.05 mu m corresponding to the dimensions of
Objective. Selective leukocyte apheresis is a new type of non-pharmacological treatment for patients with active ulcerative colitis and Crohn's disease. Preliminary data have indicated that this type of therapy is safe and efficacious, and large sham-controlled studies are currently in progress. In Scandinavia, a substantial number of patients with chronic inflammatory bowel disease have already r
The Sb-V-O, Al-Sb-V-O and Al-Sb-V-W-O systems were investigated for the ammoxidation of propane to acrylonitrile. Compared with pure approximate to SbVO4, the approximate to SbVO4 that was obtained by co-calcination of pure approximate to SbVO4 with alpha-Sb2O4 at 800 degrees C and subsequent sieving was found to be much more selective to acrylonitrile. XRD data showed no variation of the rutile u
The mechanisms behind the long duration of bronchodilating action of the beta 2-adrenoceptor agonists formoterol and salmeterol are only partially understood. This review compares pharmacological characteristics of long-acting versus short-acting beta 2-adrenoceptor agonists in human and animal airways. Based upon the reviewed evidence, it is concluded that for beta 2-adrenoceptor agonists, long d
A new method of measuring vertical dislocation of the C1 and C2 vertebra in rheumatoid arthritis is presented based on the distance from the lower end plate of C2 to the palato -occipital or McGregor 's line. In a normal material the distance was found to be 34 mm or more in men and 29 mm or more in women. A value below these limits should be regarded as vertical dislocation. In the same normal ma
Internal erosion is a major reason for embankment dam failures. Resistivity measurements is an essentially non-destructive technique, which may have the possibility of detecting internal erosion processes and anomalous seepage at an early stage before the safety of the dam is at stake. This paper presents results from part of a dam safety investigation conducted at the Enemossen tailings dam in so
This paper presents a methodological approach for the study of volatile organic compounds (VOCs) in air, emitted during storage of municipal solid waste in bales. Determination of VOCs was based on sampling with adsorbent tubes followed by automated analysis using on-line work-up with a thermal desorption unit directly connected to a gas chromatograph-mass spectrometer. Using calculation algorithm
Preterm birth is the major cause of perinatal mortality and morbidity in the developed world. Where there are no contraindications to their use, tocolytics can improve neonatal survival rates by approximately 3% per day between 23 and 27 weeks gestation with a concomitant reduction in morbidity. The ultimate aim of tocolytic therapy is to prolong pregnancy until growth and maturation is complete,
Background: The aim of this study was to develop and psychometrically test a short, patient-reported questionnaire to be used in clinical practice for patients with Irritable Bowel Syndrome (IBS). The Visual Analogue Scale for Irritable Bowel Syndrome (VAS-IBS) questionnaire was designed to measure the treatment response of symptoms and well-being in patients suffering from IBS. Methods: The VAS-I
The influence of the auxotrophic deficiencies of the host strain and expression vector selection on the production of a heterologous protein was investigated. Heterologous xylanase production by two prototrophic S. cerevisiae transformants, containing either a plasmid-based, YEp-type expression system or an integrative, YIp-type expression system, were compared with production by an auxotrophic tr
Biofuels are commonly stored in large stacks that may heat up and self-ignite from microbiological and chemical heat production. This paper shows how isothermal (heat conduction) calorimetry can be used to measure heat production rates of biofuels at relatively low temperatures close to where self-heating starts to become a problem. Measurements can be made to assess how the reaction rate is a fun
The role of immunoglobulin A (IgA) anti-tissue transglutaminase antibodies (IgA-tTG) as predictors of untreated celiac disease (CoD) is well documented, and the presence and levels of these antibodies are most accurately monitored with native or recombinant human antigens. However, IgA-deficient CoD patients are not identified by IgA serology, and conflicting results concerning the diagnostic vali
